Project measure / variable:   Donahue1   thyroxine

ID, description, units MPD:11531   thyroxine   thyroxine (serum T4)   [µg/dL]  
Data set, strains Donahue1   inbred w/CC7   29 strains     sex: both     age: 15-16wks
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  STRAIN COMPARISON PLOT
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Donahue1 - thyroxine (serum T4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means5.14   µg/dL 4.88   µg/dL
Median of the strain means4.90   µg/dL 4.50   µg/dL
SD of the strain means± 1.65 ± 1.57
Coefficient of variation (CV)0.320 0.322
Min–max range of strain means2.59   –   9.74   µg/dL 2.61   –   9.00   µg/dL
Mean sample size per strain9.4   mice 8.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 15.3706 15.3706 13.9312 0.0002
strain 28 1250.0542 44.6448 40.4642 < 0.0001
sex:strain 28 112.9836 4.0351 3.6573 < 0.0001
Residuals 456 503.1121 1.1033


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.88 0.989   10 0.313 0.255 2.7, 6.3 -0.76
129S1/SvImJ m 4.61 0.607   9 0.202 0.132 3.9, 5.8 -0.17
129X1/SvJ f 3.36 0.482   9 0.161 0.144 2.8, 4.2 -1.08
129X1/SvJ m 5.57 0.925   4 0.463 0.166 4.4, 6.6 0.44
A/J f 4.9 0.646   10 0.204 0.132 4.1, 5.8 -0.15
A/J m 4.36 0.504   10 0.159 0.116 3.3, 5.2 -0.33
AKR/J f 3.55 0.347   10 0.11 0.0978 3.0, 4.1 -0.97
AKR/J m 3.92 0.574   4 0.287 0.146 3.1, 4.4 -0.61
BALB/cJ f 7.92 0.722   10 0.228 0.0912 7.0, 9.1 1.69
BALB/cJ m 7.87 1.17   10 0.37 0.149 6.5, 10.1 1.9
BTBR T+ Itpr3tf/J f 4.34 0.41   9 0.137 0.0943 3.8, 5.1 -0.49
BTBR T+ Itpr3tf/J m 5.16 0.548   10 0.173 0.106 4.5, 5.9 0.18
BUB/BnJ f 6.64 1.42   10 0.45 0.215 3.8, 8.4 0.91
BUB/BnJ m 7.5 2.15   6 0.878 0.287 4.5, 10.3 1.67
C3H/HeJ f 9.74 2.44   10 0.772 0.251 5.3, 13.4 2.79
C3H/HeJ m 9.0 1.04   10 0.328 0.115 7.3, 11.3 2.62
C57BL/6J f 7.18 2.14   10 0.676 0.298 4.5, 10.4 1.24
C57BL/6J m 6.4 0.726   10 0.229 0.113 5.4, 7.4 0.97
C57L/J f 5.27 0.705   9 0.235 0.134 4.3, 6.5 0.08
C57L/J m 5.76 0.611   7 0.231 0.106 4.9, 6.6 0.56
C58/J f 5.69 0.858   10 0.271 0.151 3.5, 6.6 0.33
C58/J m 3.77 0.412   9 0.137 0.109 3.2, 4.5 -0.71
CAST/EiJ f 3.59 1.2   10 0.379 0.334 1.8, 5.4 -0.94
CAST/EiJ m 3.08 0.902   8 0.319 0.293 1.4, 4.6 -1.15
CZECHII/EiJ f 5.51 0.878   7 0.332 0.159 4.2, 7.0 0.23
CZECHII/EiJ m 5.91 1.02   8 0.361 0.173 4.5, 7.4 0.65
DBA/2J f 6.64 1.27   10 0.401 0.191 5.4, 9.6 0.91
DBA/2J m 5.72 1.19   10 0.376 0.208 3.5, 6.8 0.53
FVB/NJ f 3.14 0.532   9 0.177 0.169 2.0, 3.9 -1.21
FVB/NJ m 2.96 0.613   10 0.194 0.207 1.6, 3.8 -1.22
JF1/MsJ f 5.48 0.898   9 0.299 0.164 4.0, 6.6 0.21
JF1/MsJ m 3.63 1.03   10 0.325 0.283 1.9, 5.0 -0.8
MOLF/EiJ f 3.56 0.439   9 0.146 0.123 2.5, 4.0 -0.96
MOLF/EiJ m 4.21 1.15   7 0.434 0.273 3.0, 6.2 -0.43
MSM/MsJ f 4.74 0.723   5 0.323 0.153 4.0, 5.7 -0.24
MSM/MsJ m 3.77 1.21   6 0.496 0.322 1.7, 5.4 -0.71
NOD/ShiLtJ f 4.5 1.52   10 0.48 0.337 2.2, 6.6 -0.39
NOD/ShiLtJ m 3.68 1.68   9 0.561 0.458 0.9, 5.2 -0.77
NZB/BlNJ f 5.59 0.816   10 0.258 0.146 4.6, 7.2 0.27
NZB/BlNJ m 4.5 0.868   10 0.274 0.193 3.1, 5.8 -0.24
NZW/LacJ f 4.97 0.864   10 0.273 0.174 3.6, 6.3 -0.1
NZW/LacJ m 4.15 0.792   10 0.25 0.191 3.5, 6.3 -0.47
PERA/EiJ f 4.38 0.57   8 0.202 0.13 3.6, 5.5 -0.46
PERA/EiJ m 2.61 0.791   9 0.264 0.303 1.8, 4.1 -1.45
PL/J f 5.43 0.803   10 0.254 0.148 4.5, 7.4 0.18
PL/J m 6.4 0.597   6 0.244 0.0932 5.7, 7.1 0.97
PWK/PhJ f 4.13 0.642   7 0.243 0.156 3.3, 5.2 -0.61
PWK/PhJ m 4.66 1.72   9 0.573 0.369 3.2, 8.5 -0.14
SEA/GnJ f 7.59 0.929   14 0.248 0.122 6.0, 8.9 1.49
SEA/GnJ m 6.56 1.2   8 0.423 0.182 5.2, 8.9 1.07
SJL/J f 3.85 0.779   10 0.246 0.202 2.1, 5.0 -0.78
SJL/J m 3.73 1.64   10 0.52 0.441 1.6, 7.3 -0.73
SPRET/EiJ f 4.01 1.49   7 0.562 0.37 2.3, 6.8 -0.69
SPRET/EiJ m 4.17 0.778   7 0.294 0.187 2.7, 5.2 -0.45
SWR/J f 6.87 0.581   10 0.184 0.0846 6.2, 8.2 1.05
SWR/J m 5.0 1.06   9 0.353 0.212 3.5, 7.0 0.08
WSB/EiJ f 2.59 0.375   10 0.119 0.145 1.9, 3.1 -1.55
WSB/EiJ m 2.91 0.807   7 0.305 0.277 1.8, 4.2 -1.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.88 0.3322 4.5328 3.2272
129S1/SvImJ m 4.6111 0.3501 5.2992 3.923
129X1/SvJ f 3.3556 0.3501 4.0436 2.6675
129X1/SvJ m 5.575 0.5252 6.6071 4.5429
A/J f 4.9 0.3322 5.5528 4.2472
A/J m 4.36 0.3322 5.0128 3.7072
AKR/J f 3.55 0.3322 4.2028 2.8972
AKR/J m 3.925 0.5252 4.9571 2.8929
BALB/cJ f 7.92 0.3322 8.5728 7.2672
BALB/cJ m 7.87 0.3322 8.5228 7.2172
BTBR T+ Itpr3tf/J f 4.3444 0.3501 5.0325 3.6564
BTBR T+ Itpr3tf/J m 5.16 0.3322 5.8128 4.5072
BUB/BnJ f 6.64 0.3322 7.2928 5.9872
BUB/BnJ m 7.5 0.4288 8.3427 6.6573
C3H/HeJ f 9.74 0.3322 10.3928 9.0872
C3H/HeJ m 9.0 0.3322 9.6528 8.3472
C57BL/6J f 7.18 0.3322 7.8328 6.5272
C57BL/6J m 6.4 0.3322 7.0528 5.7472
C57L/J f 5.2667 0.3501 5.9547 4.5786
C57L/J m 5.7571 0.397 6.5373 4.9769
C58/J f 5.69 0.3322 6.3428 5.0372
C58/J m 3.7667 0.3501 4.4547 3.0786
CAST/EiJ f 3.59 0.3322 4.2428 2.9372
CAST/EiJ m 3.075 0.3714 3.8048 2.3452
CZECHII/EiJ f 5.5143 0.397 6.2945 4.7341
CZECHII/EiJ m 5.9125 0.3714 6.6423 5.1827
DBA/2J f 6.64 0.3322 7.2928 5.9872
DBA/2J m 5.72 0.3322 6.3728 5.0672
FVB/NJ f 3.1444 0.3501 3.8325 2.4564
FVB/NJ m 2.96 0.3322 3.6128 2.3072
JF1/MsJ f 5.4778 0.3501 6.1658 4.7897
JF1/MsJ m 3.63 0.3322 4.2828 2.9772
MOLF/EiJ f 3.5556 0.3501 4.2436 2.8675
MOLF/EiJ m 4.2143 0.397 4.9945 3.4341
MSM/MsJ f 4.74 0.4697 5.6631 3.8169
MSM/MsJ m 3.7667 0.4288 4.6094 2.924
NOD/ShiLtJ f 4.5 0.3322 5.1528 3.8472
NOD/ShiLtJ m 3.6778 0.3501 4.3658 2.9897
NZB/BlNJ f 5.59 0.3322 6.2428 4.9372
NZB/BlNJ m 4.5 0.3322 5.1528 3.8472
NZW/LacJ f 4.97 0.3322 5.6228 4.3172
NZW/LacJ m 4.15 0.3322 4.8028 3.4972
PERA/EiJ f 4.375 0.3714 5.1048 3.6452
PERA/EiJ m 2.6111 0.3501 3.2992 1.923
PL/J f 5.43 0.3322 6.0828 4.7772
PL/J m 6.4 0.4288 7.2427 5.5573
PWK/PhJ f 4.1286 0.397 4.9088 3.3484
PWK/PhJ m 4.6556 0.3501 5.3436 3.9675
SEA/GnJ f 7.5929 0.2807 8.1445 7.0412
SEA/GnJ m 6.5625 0.3714 7.2923 5.8327
SJL/J f 3.85 0.3322 4.5028 3.1972
SJL/J m 3.73 0.3322 4.3828 3.0772
SPRET/EiJ f 4.0143 0.397 4.7945 3.2341
SPRET/EiJ m 4.1714 0.397 4.9516 3.3912
SWR/J f 6.87 0.3322 7.5228 6.2172
SWR/J m 5.0 0.3501 5.6881 4.3119
WSB/EiJ f 2.59 0.3322 3.2428 1.9372
WSB/EiJ m 2.9143 0.397 3.6945 2.1341


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4.2456 0.2413 4.7198 3.7713
129X1/SvJ both 4.4653 0.3156 5.0855 3.8451
A/J both 4.63 0.2349 5.0916 4.1684
AKR/J both 3.7375 0.3107 4.3481 3.1269
BALB/cJ both 7.895 0.2349 8.3566 7.4334
BTBR T+ Itpr3tf/J both 4.7522 0.2413 5.2264 4.278
BUB/BnJ both 7.07 0.2712 7.603 6.537
C3H/HeJ both 9.37 0.2349 9.8316 8.9084
C57BL/6J both 6.79 0.2349 7.2516 6.3284
C57L/J both 5.5119 0.2647 6.032 4.9918
C58/J both 4.7283 0.2413 5.2026 4.2541
CAST/EiJ both 3.3325 0.2491 3.8221 2.8429
CZECHII/EiJ both 5.7134 0.2718 6.2476 5.1792
DBA/2J both 6.18 0.2349 6.6416 5.7184
FVB/NJ both 3.0522 0.2413 3.5264 2.578
JF1/MsJ both 4.5539 0.2413 5.0281 4.0797
MOLF/EiJ both 3.8849 0.2647 4.4051 3.3648
MSM/MsJ both 4.2533 0.318 4.8783 3.6284
NOD/ShiLtJ both 4.0889 0.2413 4.5631 3.6147
NZB/BlNJ both 5.045 0.2349 5.5066 4.5834
NZW/LacJ both 4.56 0.2349 5.0216 4.0984
PERA/EiJ both 3.4931 0.2552 3.9946 2.9915
PL/J both 5.915 0.2712 6.448 5.382
PWK/PhJ both 4.3921 0.2647 4.9122 3.8719
SEA/GnJ both 7.0777 0.2328 7.5351 6.6202
SJL/J both 3.79 0.2349 4.2516 3.3284
SPRET/EiJ both 4.0929 0.2807 4.6445 3.5412
SWR/J both 5.935 0.2413 6.4092 5.4608
WSB/EiJ both 2.7521 0.2588 3.2608 2.2435




  GWAS USING LINEAR MIXED MODELS