Loos2: Sheltering behavior and locomotor activity in males of 11 inbred strains of mice and within-strain variation of 8 of those strains (2016)

Loos M, Koopmans B, Aarts E, Maroteaux G, van der Sluis S; Neuro-BSIK Mouse Phenomics Consortium, Verhage M, Smit AB. Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. PLoS One. 2014 Sep 29;9(9):e108563. doi: 10.1371/journal.pone.0108563. eCollection 2014.   PubMed 25264768     FullText

Loos2 downloads
• Download Loos2 project data set     animal data, as uploaded
• Download Loos2 animal data matrix     with factor-related expansion applied as necessary
• Download Loos2 strain means, SD, N, etc.     one row per strain/sex/measure
• Loos2 supplementary data
Investigators Maarten Loos       Sylics,  Amsterdam NETHERLANDS
Bastijn Koopmans       Sylics,  Amsterdam NETHERLANDS
Participants Aarts E, Maroteaux G, van der Sluis S, Verhage M, Smit AB, Neuro-BSIK Mouse Phenomics Consortium
ContactMaarten Loos     maarten.loos@sylics.com     Lab web site
AcknowledgementsFunding provided by Agentschap NL (NeuroBSIK Mouse Phenomics Consortium, BSIK03053); NeuroBasic PharmaPhenomics Consortium (LSH framework FES0908); Netherlands Organization for Scientific Research (NWO/MaGW: VIDI-452-12-014)
Project type Phenotype strain survey data set
MPD identifiersLoos2     MPD:540
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
This study aimed to determine the aspects of spontaneous mouse homecage behavior that are most influenced by genetic variation. Behavior was recorded for three consecutive days in a home-cage system by 24/7 overhead video tracking for each animal individually. Continuous video-tracking observations of sheltering behavior and locomotor activity were segmented into distinguishable behavioral elements, yielding a set of 115 behavioral parameters which demonstrated high dimensionality. Sixty-seven of those measurements have been accessioned here. Within-strain variation in behavior was also assessed. Selected measurements were log10 transformed by the investigators.

Procedures conducted:
• home cage monitoring  Locomotor activity, sheltering, habituation. 3 day home-cage assessment.

Mice: inbred w/CC7   11 strains   ♂   age 8-12wks   1 experimental group