Loos2: Sheltering behavior and locomotor activity in males of 11 inbred strains of mice and within-strain variation of 8 of those strains (2016)

Loos M, Koopmans B, Aarts E, Maroteaux G, van der Sluis S; Neuro-BSIK Mouse Phenomics Consortium, Verhage M, Smit AB. Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. PLoS One. 2014 Sep 29;9(9):e108563. doi: 10.1371/journal.pone.0108563. eCollection 2014.   PubMed 25264768     FullText

Loos2 downloads
• Download Loos2 project data set     one row per animal, one column per trait
• Download Loos2 strain means, SD, N, etc.     one row per strain/sex/measure
• Loos2 supplementary data
Participants Maarten Loos       Sylics Amsterdam NETHERLANDS
Bastijn Koopmans       Sylics Amsterdam NETHERLANDS
With: Aarts E, Maroteaux G, van der Sluis S, Verhage M, Smit AB, Neuro-BSIK Mouse Phenomics Consortium
ContactMaarten Loos     maarten.loos@sylics.com     Lab web site
AcknowledgementsFunding provided by Agentschap NL (NeuroBSIK Mouse Phenomics Consortium, BSIK03053); NeuroBasic PharmaPhenomics Consortium (LSH framework FES0908); Netherlands Organization for Scientific Research (NWO/MaGW: VIDI-452-12-014)
Project type Phenotype strain survey data set
MPD identifiersLoos2     MPD:540
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
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This study aimed to determine the aspects of spontaneous mouse homecage behavior that are most influenced by genetic variation. Behavior was recorded for three consecutive days in a home-cage system by 24/7 overhead video tracking for each animal individually. Continuous video-tracking observations of sheltering behavior and locomotor activity were segmented into distinguishable behavioral elements, yielding a set of 115 behavioral parameters which demonstrated high dimensionality. Sixty-seven of those measurements have been accessioned here. Within-strain variation in behavior was also assessed. Selected measurements were log10 transformed by the investigators.

Summary of procedures that were conducted
• home cage monitoring Locomotor activity, sheltering, habituation. 3 day home-cage assessment.
Mice: inbred w/CC7   11 strains   ♂   age 8-12wks   1 cohort