Palmer5: Behavioral and metabolic traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/+ for the Tcf7l2 gene (2017)

Sittig LJ, Carbonetto P, Engel KA, Krauss KS, Barrios-Camacho CM, Palmer AA. Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. Neuron. 2016 Sep 21;91(6):1253-9. doi: 10.1016/j.neuron.2016.08.013. Epub 2016 Sep 8.   PubMed 27618673  

Palmer5 downloads
• Download Palmer5 project data set     animal data, as uploaded
• Download Palmer5 animal data matrix     with factor-related expansion applied as necessary
• Download Palmer5 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Laura J Sittig       University of Chicago,  Chicago, IL
Abraham A Palmer       University of California, San Diego,  San Diego, CA
Participants Carbonetto P, Engel KA, Krauss KS, Barrios-Camacho CM
ContactAbraham A Palmer     Lab web site
Part of a series: • Tcf7l2 +/+   (this project) Palmer5
• Tcf7l2 +/-   see Palmer3
• Cacna1c +/+   see Palmer6
• Cacna1c +/-   see Palmer4
Project type Phenotype strain survey data set
MPD identifiersPalmer5     MPD:597
Data changelog No updates/corrections.       Initial release date: 09/2017.
Formatted citation
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F1 crosses were produced between male C57BL/6J mice heterozygous for the null allele of Tcf7l2 and wild-type females from 30 inbred laboratory strains. This gene is among the most strongly associated and best replicated genetic risk factors for type 2 diabetes. It has also been associated with schizophrenia and bipolar disorder. The generalizability of Tcf7l2 +/- physiological and behavioral phenotypes was evaluated using these 30 genetic backgrounds (see Sittig1). This project (Sittig3) contains data for the +/+ littermate controls. Data for +/+ and +/- littermates are summarized graphically here.

Procedures conducted:
• body weight 
• open field test  Locomotor and exploratory behavior. 30 min test.
• fear conditioning test  Contextual fear, cued fear.
• acoustic startle test  Acoustic startle response, prepulse inhibition.
• forced swim test  Immobility time. 6 min test.
• metabolic panel  Glucose (blood). Before and after 16h fast.

Mice: F1 Tcf7l2   30 strains   ♀♂   age 7-14wks   1 experimental group