Palmer3: Behavioral and metabolic traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/- for the Tcf7l2 gene (2017)

Sittig LJ, Carbonetto P, Engel KA, Krauss KS, Barrios-Camacho CM, Palmer AA. Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. Neuron. 2016 Sep 21;91(6):1253-9. doi: 10.1016/j.neuron.2016.08.013. Epub 2016 Sep 8.   PubMed 27618673  

Palmer3 downloads
• Download Palmer3 project data set     one row per animal, one column per trait
• Download Palmer3 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Laura J Sittig       University of Chicago Chicago, IL
Abraham A Palmer       University of California, San Diego San Diego, CA
With: Carbonetto P, Engel KA, Krauss KS, Barrios-Camacho CM
ContactAbraham A Palmer     Lab web site
Part of a series: • Tcf7l2 +/+   see Palmer5
• Tcf7l2 +/-   (this project) Palmer3
• Cacna1c +/+   see Palmer6
• Cacna1c +/-   see Palmer4
Project type Phenotype strain survey data set
MPD identifiersPalmer3     MPD:592
Data changelog No updates/corrections.       Initial release date: 09/2017.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
F1 crosses were produced between male C57BL/6J mice heterozygous for the null allele of Tcf7l2 and wild-type females from 30 inbred laboratory strains. This gene is among the most strongly associated and best replicated genetic risk factors for type 2 diabetes. It has also been associated with schizophrenia and bipolar disorder. The generalizability of Tcf7l2 +/- physiological and behavioral phenotypes was evaluated using these 30 genetic backgrounds. Data for +/+ and +/- littermates are summarized graphically here. Data were downloaded from

Summary of procedures that were conducted
• body weight
• open field test Locomotor and exploratory behavior. 30 min test.
• fear conditioning test Contextual fear, cued fear.
• acoustic startle test Acoustic startle response, prepulse inhibition.
• forced swim test Immobility time. 6 min test.
• metabolic panel Glucose (blood). Before and after 16h fast.
Mice: F1 Tcf7l2   30 strains   ♀♂   age 7-14wks   1 cohort