Palmer6: Behavioral traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/+ for the Cacna1c gene (2017)

Sittig LJ, Carbonetto P, Engel KA, Krauss KS, Barrios-Camacho CM, Palmer AA. Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. Neuron. 2016 Sep 21;91(6):1253-9. doi: 10.1016/j.neuron.2016.08.013. Epub 2016 Sep 8.   PubMed 27618673  


       
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Participants Laura J Sittig       University of Chicago Chicago, IL
Abraham A Palmer       University of California, San Diego San Diego, CA
With: Carbonetto P, Engel KA, Krauss KS, Barrios-Camacho CM
ContactAbraham A Palmer     aapalmer@ucsd.edu     Lab web site
Part of a series: • Tcf7l2 +/+   see Palmer5
• Tcf7l2 +/-   see Palmer3
• Cacna1c +/+   (this project) Palmer6
• Cacna1c +/-   see Palmer4
Project type Phenotype strain survey data set
MPD identifiersPalmer6     MPD:598
Data changelog No updates/corrections.       Initial release date: 09/2017.
Formatted citation
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F1 crosses were produced between male C57BL/6J mice heterozygous for the null allele of Cacna1c and wild-type females from 30 inbred laboratory strains. This gene has been associated with schizophrenia and bipolar disorder. The generalizability of Cacna1c +/- behavioral phenotypes was evaluated using these 30 genetic backgrounds (see Sittig2). This project (Sittig4) contains data for +/+ littermate controls. Data for +/+ and +/- littermates are summarized graphically here.

Summary of procedures that were conducted
• body weight
• light-dark box Anxiety-related. 5 min test.
• open field test Locomotor and exploratory activity, anxiety-related behavior, methamphetamine sensitivity. 30 min test.
• forced swim test Immobility time. 6 min test.
• acoustic startle test Acoustic startle response.
Mice: F1 Cacna1c   30 strains   ♀♂   age 7-14wks   1 cohort