Rusyn6 supplemental data

Trichloroethylene metabolism and tissue-specific toxicity in males of 7 inbred strains of mice   (2014)

Rusyn I
With: Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A


Jentsch2_suppdata

Supplementary Data

Abbreviations   Submitted var_name (units)
TCA Trichloroacetic acid  
DCA Dichloroacetic acid  
TCOH Trichloroethanol  
DCVG S-(1,2-dichlorovinyl)glutathione  
DCVC S-(1,2-dichlorovinyl)-L-cysteine  
BrdU 5-Bromo-2´-Deoxyuridine  
BUN Blood Urea Nitrogen

 

KIM-1 Kidney Injury Molecule-1  
blloq Below the lower limit of quantification  
    liver DCA (nmol/g)
    liver TCOH (nmol/g)
    liver DCVG (pmol/g)
    serum TCA (nmol/mL)
    serum DCA (nmol/mL)
    CYP2E1 in liver (relative to vehicle)
    ALDH2 in liver (relative to vehicle)
    ADH in liver (relative to vehicle)
    liver/body weight ratio
    BrdU-positive nuclei in liver (%)
    Ppara mRNA in liver (relative to vehicle)
    Acox1 mRNA in liver (relative to vehicle)
    Cyp4a10 mRNA in liver (relative to vehicle)
    kidney TCA (nmol/g)
    kidney DCA (nmol/g)
    kidney TCOH (nmol/g)
    kidney/body weight ratio
    BUN (mg/dL)
    serum creatinine (mg/dL)
    Ppara mRNA in kidney (relative to vehicle)
    Acox1 mRNA in kidney (relative to vehicle)
    Cyp4a10 mRNA in kidney (relative to vehicle)
    BrdU-positive nuclei in kidney (%)
    KIM-1 positive renal tubules (%)

Download supplementary data: Rusyn6_suppdata.xlxs