Richfield1: Behavioral, neurochemical, neuroanatomical, and neurotoxicological survey of the midbrain dopamine system in males of 15 inbred strains of mice (2003)

Mhyre TR, Chesler EJ, Thiruchelvam M, Lungu C, Cory-Slechta DA, Fry JD, Richfield EK. Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice. Genes Brain Behav. 2005 Jun;4(4):209-28.   PubMed 15924554  


         
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Investigators Eric K Richfield       Environmental and Occupational Health Science Institute ,  Piscataway, NJ
Timothy R Mhyre       University of Rochester School of Medicine and Dentistry,  Rochester, NY
Deborah A Cory-Slechta       Environmental and Occupational Health Science Institute ,  Piscataway, NJ
Mona Thiruchelvam       Environmental and Occupational Health Science Institute ,  Piscataway, NJ
Elissa J Chesler       The Jackson Laboratory,  Bar Harbor, ME
Participants Fry J, Lungu C
ContactEric K Richfield     ekr@eohsi.rutgers.edu
AcknowledgementsFunding provided by NIH ES11839, DOD DAMD17-98-1-8628.
Project type Phenotype strain survey data set
MPD identifiersRichfield1     MPD:145
Data changelog 2 updates/corrections.       Initial release date: 04/2008.
Formatted citation
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Locomotor behavioral parameters and neurotransmitter concentrations related to the midbrain dopamine system were assessed. The midbrain dopamine system is an important mediator of both normal and pathologic behaviors in many species, including humans. As such, it has received considerable attention regarding its roles in aspects of motor activity, attention, motivation/reward, and cognition.

Summary of procedures that were conducted
• open field test Locomotor activity. 3 day trials. 45 min sessions.
• neurotransmitter quantification Neurotransmitters. Molecular measures.
Mice: inbred   15 strains   ♂   age 7-9wks   1 experimental group