Richfield1: Behavioral, neurochemical, neuroanatomical, and neurotoxicological survey of the midbrain dopamine system in males of 15 inbred strains of mice (2003)

Mhyre TR, Chesler EJ, Thiruchelvam M, Lungu C, Cory-Slechta DA, Fry JD, Richfield EK. Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice. Genes Brain Behav. 2005 Jun;4(4):209-28.   PubMed 15924554  

Richfield1 downloads
• Download Richfield1 project data set     one row per animal, one column per trait
• Download Richfield1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Eric K Richfield       Environmental and Occupational Health Science Institute Piscataway, NJ
Timothy R Mhyre       University of Rochester School of Medicine and Dentistry Rochester, NY
Deborah A Cory-Slechta       Environmental and Occupational Health Science Institute Piscataway, NJ
Mona Thiruchelvam       Environmental and Occupational Health Science Institute Piscataway, NJ
Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
With: Fry J, Lungu C
ContactEric K Richfield
AcknowledgementsFunding provided by NIH ES11839, DOD DAMD17-98-1-8628.
Project type Phenotype strain survey data set
MPD identifiersRichfield1     MPD:145
Data changelog 2 updates/corrections.       Initial release date: 04/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Locomotor behavioral parameters and neurotransmitter concentrations related to the midbrain dopamine system were assessed. The midbrain dopamine system is an important mediator of both normal and pathologic behaviors in many species, including humans. As such, it has received considerable attention regarding its roles in aspects of motor activity, attention, motivation/reward, and cognition.

Summary of procedures that were conducted
• open field test Locomotor activity. 3 day trials. 45 min sessions.
• neurotransmitter quantification Neurotransmitters. Molecular measures.
Mice: inbred   15 strains   ♂   age 7-9wks   1 cohort