MPD: Phenotype measures mapped to MA:0000358, liver

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Threadgill1:1	Threadgill1	organ weights	acetaminophen	liver weight 24h after treatment [g] liverwt 19401 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=4	2005

Threadgill1:4	Threadgill1	histopathology	acetaminophen	necrosis [%] liver_necrosis 19404 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:14	Threadgill1	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:16	Threadgill1	metabolite quantification	acetaminophen	oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:18	Threadgill1	metabolite quantification	acetaminophen	total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:20	Threadgill1	metabolite quantification	acetaminophen	ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:82	Threadgill1	metabolic panel	acetaminophen	catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:83	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:84	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:86	Threadgill1	metabolite quantification	acetaminophen	glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1

organ weights

acetaminophen

liver weight 24h after treatment [g] liverwt 19401 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=4

2005

Threadgill1

histopathology

acetaminophen

necrosis [%] liver_necrosis 19404 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolic panel

acetaminophen

catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

biomarker quantification

acetaminophen

cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

biomarker quantification

acetaminophen

cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

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