MPD: Data set: Odet1

Odet F, Pan W, Bell TA, Goodson SG, Stevans AM, Yun Z, Aylor DL, Kao CY, McMillan L, de Villena FP, O'Brien DA. The Founder Strains of the Collaborative Cross Express a Complex Combination of Advantageous and Deleterious Traits for Male Reproduction. G3 (Bethesda). 2015 Oct 19;5(12):2671-83. doi: 10.1534/g3.115.020172. PubMed 26483008

Odet1 downloads
• Download Odet1 project data set animal data, as uploaded
• Download Odet1 animal data matrix with factor-related expansion applied as necessary
• Download Odet1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Odet1 measures:

MA:0000397 epididymis
MA:0000410 seminal vesicle
MA:0000411 testis
MA:0000412 seminiferous tubule
MA:0000413 vas deferens
MA:0002765 male germ cell
MP:0001259 abnormal body weight
MP:0002216 abnormal seminiferous tubule morphology
MP:0002673 abnormal sperm number
MP:0004543 abnormal sperm physiology
MP:0004850 abnormal testis weight
MP:0004908 abnormal seminal vesicle weight
MP:0004926 abnormal epididymis size
MP:0006362 abnormal male germ cell morphology
MP:0008892 abnormal sperm flagellum morphology
MP:0009230 abnormal sperm head morphology
VT:0001259 body mass
VT:0001922 male fertility trait
VT:0002121 metabolism trait
VT:0002216 seminiferous tubule morphology trait
VT:0002673 sperm quantity
VT:0002997 seminal gland size trait
VT:0010019 epididymis mass
VT:0010042 sperm morphology trait
VT:1000644 testis mass

Investigators	Deborah A O'Brien University of North Carolina, Chapel Hill, NC Fanny Odet University of North Carolina, Chapel Hill, NC Wenqi Pan University of North Carolina, Chapel Hill, NC Fernando Pardo-Manuel de Villena University of North Carolina, Chapel Hill, NC
Participants	Bell TA, Goodson SG, Stevans AM, Yun Z, Aylor DL, Kao C-Y, McMillan L
Contact	Deborah A O'Brien dao@med.unc.edu Lab web site
Part of a series:	• Morphology, histology, metabolism (this project) Odet1 • Sperm motility see Odet2
Project type	Phenotype strain survey data set
MPD identifiers	Odet1 MPD:537
Data changelog	No updates/corrections. Initial release date: 04/2016.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Procedures conducted:

• body weight
• organ weights		Male reproductive organ weights. Testes, seminal vesicles, epididymis, vas deferens.
• histopathology		Male reproductive histopathology. Percent normal vs. abnormal sperm, seminiferous tubules.
• sperm count		Sperm count. Hemocytometer.
• metabolic panel		Male reproductive sperm lactate production.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Odet1:1	Odet1	body weight	(none)	body_weight [g] bw 53701	inbred w/CC8	8	m	10-66wks	N=29

Odet1:11	Odet1	organ weights	(none)	mean epididymis plus vas deferens weight [g] epidid_vasdef_wt 53711	inbred w/CC8	8	m	10-66wks	N=21

Odet1:12	Odet1	organ weights	(none)	seminal vesicles weight [g] seminal_ves_wt 53712	inbred w/CC8	8	m	10-66wks	N=27

Odet1:13	Odet1	organ weights	(none)	mean testis weight [g] testis_wt 53713	inbred w/CC8	8	m	10-66wks	N=27

Odet1:21	Odet1	histopathology	(none)	mean seminiferous tubule radius, transverse section [µm] seminif_radius 53721	inbred w/CC8	8	m	10-66wks	N=26

Odet1:22	Odet1	histopathology	(none)	seminiferious epithelium length, transverse section [cm] seminif_length 53722	inbred w/CC8	8	m	10-66wks	N=26

Odet1:23	Odet1	histopathology	(none)	number of seminiferous tubules, transverse section [n] seminif_count 53723	inbred w/CC8	8	m	10-66wks	N=26

Odet1:24	Odet1	histopathology	(none)	number of seminiferous tubules with vacuoles, transverse section [n] seminif_vacuoles 53724	inbred w/CC8	8	m	10-66wks	N=26

Odet1:25	Odet1	histopathology	(none)	number of seminiferous tubules with many vacuoles, transverse section [n] seminif_many_vacuoles 53725	inbred w/CC8	8	m	10-66wks	N=26

Odet1:26	Odet1	histopathology	(none)	number of seminiferous tubules with germ cell loss, transverse section [n] seminif_germ_loss 53726	inbred w/CC8	8	m	10-66wks	N=18

Odet1:27	Odet1	histopathology	(none)	number of seminiferous tubules with abnormal germ cells, transverse section [n] seminif_germ_abnormal 53727	inbred w/CC8	8	m	10-66wks	N=26

Odet1:28	Odet1	histopathology	(none)	number of seminiferous tubules with germ cell sloughing, transverse section [n] seminif_germ_slough 53728	inbred w/CC8	8	m	10-66wks	N=26

Odet1:31	Odet1	sperm count	(none)	sperm count per mouse (x 10⁶) [n] sperm_per_mouse 53731	inbred w/CC8	8	m	10-66wks	N=21

Odet1:32	Odet1	sperm count	(none)	sperm count per mg testis weight (x 10³) [n] sperm_per_testis 53732	inbred w/CC8	8	m	10-66wks	N=20

Odet1:33	Odet1	sperm count	(none)	sperm count per seminiferous epithelium length (x 10³) [n] sperm_per_seminif 53733	inbred w/CC8	8	m	10-66wks	N=19

Odet1:41	Odet1	histopathology	(none)	percentage of sperm with normal morphology [%] sperm_normal 53741	inbred w/CC8	8	m	10-66wks	N=14

Odet1:42	Odet1	histopathology	(none)	percentage of sperm with abnormal head shape [%] sperm_abnormal_head 53742	inbred w/CC8	8	m	10-66wks	N=14

Odet1:43	Odet1	histopathology	(none)	percentage of sperm with abnormal tail bending [%] sperm_abnormal_tail 53743	inbred w/CC8	8	m	10-66wks	N=14

Odet1:44	Odet1	histopathology	(none)	percentage of sperm with broken tails [%] sperm_broken_tail 53744	inbred w/CC8	8	m	10-66wks	N=14

Odet1:51	Odet1	metabolic panel	(none)	lactate production per 10⁸ sperm [µmole] sperm_lactate 53751	inbred w/CC8	8	m	10-66wks	N=8

Odet1: Male reproduction in 8 inbred founder strains of the Collaborative Cross: Organ weights, testis histology and sperm count, morphology and metabolism (2015)

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