MPD: Phenotype measures mapped to VT:0010721, response to nicotine trait

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Gould2:1	Gould2	drug and metabolite quantification	nicotine	plasma nicotine [ng/mL] nicotine 47101 acute 0.09mg dose chronic 6.3mg dose	inbred	8	m	8-12wks	N=10	2011

Gould2:3	Gould2	drug and metabolite quantification	nicotine	plasma cotinine [ng/mL] cotinine 47105 acute 0.09mg dose chronic 6.3mg dose	inbred	8	m	8-12wks	N=10	2011

Gould2:5	Gould2	behavior observation	nicotine	chronic group, grooming [n] grooming 47111 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould2:7	Gould2	behavior observation	nicotine	chronic group, scratching [n] scratching 47113 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould2:9	Gould2	behavior observation	nicotine	chronic group, jumping [n] jumping 47115 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould2:11	Gould2	elevated plus maze	nicotine	chronic group, time in closed arms [%] EPM_pct_closed 47121 control nicotine	inbred	8	m	8-12wks	N=9	2011

Gould2:13	Gould2	elevated plus maze	nicotine	chronic group, time in open arms [%] EPM_pct_open 47123 control nicotine	inbred	8	m	8-12wks	N=9	2011

Gould2:15	Gould2	elevated plus maze	nicotine	chronic group, time in center [%] EPM_pct_center 47125 control nicotine	inbred	8	m	8-12wks	N=9	2011

Gould2:17	Gould2	fear conditioning test	nicotine	acute group, percent immobility in training chamber after first stimulus pairing [%] FC_immediate_acu 47131 dose (mg): control 0.045 0.09 0.18	inbred	8	m	8-12wks	N=11	2011

Gould2:21	Gould2	fear conditioning test	nicotine	acute group, percent immobility in training chamber, 24h after fear conditioning [%] FC_context_acu 47136 dose (mg): control 0.045 0.09 0.18	inbred	8	m	8-12wks	N=11	2011

Gould2:25	Gould2	fear conditioning test	nicotine	acute group, percent immobility in altered context chamber, pre-cue [%] FC_preCS_acu 47141 dose (mg): control 0.045 0.09 0.18	inbred	8	m	8-12wks	N=11	2011

Gould2:29	Gould2	fear conditioning test	nicotine	acute group, percent immobility in altered context chamber, cue [%] FC_CS_acu 47146 dose (mg) control 0.045 0.09 0.18	inbred	8	m	8-12wks	N=11	2011

Gould2:33	Gould2	fear conditioning test	nicotine	chronic group, conditioning: immediate fear [%] FC_immediate_chr 47151 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould2:35	Gould2	fear conditioning test	nicotine	chronic group, conditioning: contextual fear [%] FC_context_chr 47156 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould2:37	Gould2	fear conditioning test	nicotine	chronic group, cued fear: pre-cue [%] FC_preCS_chr 47161 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould2:39	Gould2	fear conditioning test	nicotine	chronic group, cued fear: cue [%] FC_CS_chr 47166 control nicotine	inbred	8	m	8-12wks	N=10	2011

Gould3:1	Gould3	behavior observation	nicotine	withdrawal study group, number of grooming episodes, 20 min test [n] grooming 47301 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=11	2011

Gould3:6	Gould3	behavior observation	nicotine	withdrawal study group, number of scratching episodes, 20 min test [n] scratching 47306 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=11	2011

Gould3:11	Gould3	behavior observation	nicotine	withdrawal study group, number of jumping episodes, 20 min test [n] jumping 47311 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=11	2011

Gould3:21	Gould3	elevated plus maze	nicotine	withdrawal study group, percentage of time in closed arms [%] EPM_pct_closed 47321 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=10	2011

Gould3:26	Gould3	elevated plus maze	nicotine	withdrawal study group, percentage of time in open arms [%] EPM_pct_open 47326 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=10	2011

Gould3:31	Gould3	elevated plus maze	nicotine	withdrawal study group, percentage of time in center [%] EPM_pct_center 47331 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=10	2011

Gould3:41	Gould3	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] FC_immediate 47341 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=12	2011

Gould3:46	Gould3	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] FC_context 47346 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=12	2011

Gould3:61	Gould3	fear conditioning test	nicotine	withdrawal study group, percent immobility in altered context chamber, pre-cue [%] FC_preCS 47361 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=12	2011

Gould3:66	Gould3	fear conditioning test	nicotine	withdrawal study group, percent immobility in altered context chamber, cue [%] FC_CS 47366 control nicotine dose (mg) 3 6.3 12	inbred	8	m	8-12wks	N=12	2011

Gould4:1	Gould4	conditioned place preference test	nicotine	conditioned place preference score for test 1 [s] pref_score1 54701 control nicotine	inbred	8	m	8-10wks	N=9	2014

Gould4:11	Gould4	conditioned place preference test	nicotine	conditioned place preference score for test 2 [s] pref_score2 54711 control nicotine	inbred	8	m	8-10wks	N=9	2014

Gould2

drug and metabolite quantification

nicotine

plasma nicotine [ng/mL] nicotine 47101 acute 0.09mg dose chronic 6.3mg dose

inbred

8

m

8-12wks

N=10

2011

Gould2

drug and metabolite quantification

nicotine

plasma cotinine [ng/mL] cotinine 47105 acute 0.09mg dose chronic 6.3mg dose

inbred

8

m

8-12wks

N=10

2011

Gould2

behavior observation

nicotine

chronic group, grooming [n] grooming 47111 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould2

behavior observation

nicotine

chronic group, scratching [n] scratching 47113 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould2

behavior observation

nicotine

chronic group, jumping [n] jumping 47115 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould2

elevated plus maze

nicotine

chronic group, time in closed arms [%] EPM_pct_closed 47121 control nicotine

inbred

8

m

8-12wks

N=9

2011

Gould2

elevated plus maze

nicotine

chronic group, time in open arms [%] EPM_pct_open 47123 control nicotine

inbred

8

m

8-12wks

N=9

2011

Gould2

elevated plus maze

nicotine

chronic group, time in center [%] EPM_pct_center 47125 control nicotine

inbred

8

m

8-12wks

N=9

2011

Gould2

fear conditioning test

nicotine

acute group, percent immobility in training chamber after first stimulus pairing [%] FC_immediate_acu 47131 dose (mg): control 0.045 0.09 0.18

inbred

8

m

8-12wks

N=11

2011

Gould2

fear conditioning test

nicotine

acute group, percent immobility in training chamber, 24h after fear conditioning [%] FC_context_acu 47136 dose (mg): control 0.045 0.09 0.18

inbred

8

m

8-12wks

N=11

2011

Gould2

fear conditioning test

nicotine

acute group, percent immobility in altered context chamber, pre-cue [%] FC_preCS_acu 47141 dose (mg): control 0.045 0.09 0.18

inbred

8

m

8-12wks

N=11

2011

Gould2

fear conditioning test

nicotine

acute group, percent immobility in altered context chamber, cue [%] FC_CS_acu 47146 dose (mg) control 0.045 0.09 0.18

inbred

8

m

8-12wks

N=11

2011

Gould2

fear conditioning test

nicotine

chronic group, conditioning: immediate fear [%] FC_immediate_chr 47151 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould2

fear conditioning test

nicotine

chronic group, conditioning: contextual fear [%] FC_context_chr 47156 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould2

fear conditioning test

nicotine

chronic group, cued fear: pre-cue [%] FC_preCS_chr 47161 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould2

fear conditioning test

nicotine

chronic group, cued fear: cue [%] FC_CS_chr 47166 control nicotine

inbred

8

m

8-12wks

N=10

2011

Gould3

behavior observation

nicotine

withdrawal study group, number of grooming episodes, 20 min test [n] grooming 47301 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=11

2011

Gould3

behavior observation

nicotine

withdrawal study group, number of scratching episodes, 20 min test [n] scratching 47306 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=11

2011

Gould3

behavior observation

nicotine

withdrawal study group, number of jumping episodes, 20 min test [n] jumping 47311 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=11

2011

Gould3

elevated plus maze

nicotine

withdrawal study group, percentage of time in closed arms [%] EPM_pct_closed 47321 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=10

2011

Gould3

elevated plus maze

nicotine

withdrawal study group, percentage of time in open arms [%] EPM_pct_open 47326 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=10

2011

Gould3

elevated plus maze

nicotine

withdrawal study group, percentage of time in center [%] EPM_pct_center 47331 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=10

2011

Gould3

fear conditioning test

nicotine

withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] FC_immediate 47341 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=12

2011

Gould3

fear conditioning test

nicotine

withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] FC_context 47346 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=12

2011

Gould3

fear conditioning test

nicotine

withdrawal study group, percent immobility in altered context chamber, pre-cue [%] FC_preCS 47361 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=12

2011

Gould3

fear conditioning test

nicotine

withdrawal study group, percent immobility in altered context chamber, cue [%] FC_CS 47366 control nicotine dose (mg) 3 6.3 12

inbred

8

m

8-12wks

N=12

2011

Gould4

conditioned place preference test

nicotine

conditioned place preference score for test 1 [s] pref_score1 54701 control nicotine

inbred

8

m

8-10wks

N=9

2014

Gould4

conditioned place preference test

nicotine

conditioned place preference score for test 2 [s] pref_score2 54711 control nicotine

inbred

8

m

8-10wks

N=9

2014

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