MPD: Project measures / variables set: Gould3 grooming

Project measures / variables set: Gould3 grooming

ID, description, units	MPD:47301 grooming withdrawal study group, number of grooming episodes, 20 min test [n] nicotine study
Measures	• control • nicotine dose (mg) • 3 • 6.3 • 12
Data set, strains	Gould3 inbred 8 strains sex: m age: 8-12wks
Procedure	behavior observation
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0010716 anxiety-related behavior trait VT:0010721 response to nicotine trait VT:0010722 withdrawal response to addictive substance trait VT:0001440 grooming behavior trait MP:0001362 abnormal anxiety-related response MP:0001440 abnormal grooming behavior MP:0009774 abnormal behavioral withdrawal response MP:0020160 abnormal behavioral response to nicotine

Values Means Δ Means Z-scores

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Gould3 - withdrawal study group, number of grooming episodes, 20 min test

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	20.3988	6.7996	3.9502	0.0087
strain	7	428.7794	61.2542	35.5853	< 0.0001
dose:strain	21	72.4333	3.4492	2.0038	0.0062
Residuals	313	538.777	1.7213

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould3	47301	behavior observation	nicotine	withdrawal study group, number of grooming episodes, 20 min test [n] control grooming_0	inbred	8	m	8-12wks
Gould3	47302	behavior observation	nicotine	withdrawal study group, number of grooming episodes, 20 min test [n] dose: 3 mg grooming_3	inbred	8	m	8-12wks
Gould3	47303	behavior observation	nicotine	withdrawal study group, number of grooming episodes, 20 min test [n] dose: 6.3 mg grooming_6	inbred	8	m	8-12wks
Gould3	47304	behavior observation	nicotine	withdrawal study group, number of grooming episodes, 20 min test [n] dose: 12 mg grooming_12	inbred	8	m	8-12wks