Gould3: Drug study: Effects of nicotine withdrawal on fear conditioning and other behaviors in males of 8 inbred mouse strains (2011)

Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.   PubMed 21822688  

Gould3 downloads
• Download Gould3 project data set     animal data, as uploaded
• Download Gould3 animal data matrix     with factor-related expansion applied as necessary
• Download Gould3 strain means, SD, N, etc.     one row per strain/sex/measure
• Gould3 supplementary data
Investigators George S Portugal       Columbia University,  New York, NY
Thomas J Gould       Temple University,  Philadelphia, PA
Participants Wilkinson DS, Kenney JW, Sullivan C
ContactThomas J Gould     tgould@temple.edu     Lab web site
Part of a series: • nicotine acute and chronic study groups   see Gould2
• nicotine withdrawal study group   (this project) Gould3
AcknowledgementsFunding provided by NIH DA017949, DA024787, CA143187
Project type Phenotype strain survey data set
MPD identifiersGould3     MPD:473
Data changelog No updates/corrections.       Initial release date: 05/2013.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
This project contains the withdrawal study component from the Gould nicotine study. Cohorts here include saline controls and nicotine dose groups of 3, 6.3, and 12 mg/kg.

Procedures conducted:
• behavior observation  Observed measures of anxiety during nicotine withdrawal. Nicotine (several high doses) vs. control.
• elevated plus maze  Measures of anxiety during nicotine withdrawal. Nicotine (several high doses) vs. control.
• fear conditioning test  Contextual fear, cued fear during nicotine withdrawal. Nicotine (high and several lower doses) vs. control.

Mice: inbred   8 strains   ♂   age 8-12wks   4 experimental groups