Gould3: Drug study: Effects of nicotine withdrawal on fear conditioning and other behaviors in males of 8 inbred mouse strains (2011)

Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.   PubMed 21822688  


       
Gould3 downloads
• Download Gould3 project data set     one row per animal, one column per trait
• Download Gould3 strain means, SD, N, etc.     one row per strain/sex/measure
• Gould3 supplementary data
Participants George S Portugal       Columbia University New York, NY
Thomas J Gould       Temple University Philadelphia, PA
With: Wilkinson DS, Kenney JW, Sullivan C
ContactThomas J Gould     tgould@temple.edu     Lab web site
Part of a series: • nicotine acute and chronic study groups   see Gould2
• nicotine withdrawal study group   (this project) Gould3
AcknowledgementsFunding provided by NIH DA017949, DA024787, CA143187
Project type Phenotype strain survey data set
MPD identifiersGould3     MPD:473
Data changelog No updates/corrections.       Initial release date: 05/2013.
Formatted citation
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This project contains the withdrawal study component from the Gould nicotine study. Cohorts here include saline controls and nicotine dose groups of 3, 6.3, and 12 mg/kg.

Summary of procedures that were conducted
• behavior observation Observed measures of anxiety during nicotine withdrawal. Nicotine (several high doses) vs. control.
• elevated plus maze Measures of anxiety during nicotine withdrawal. Nicotine (several high doses) vs. control.
• fear conditioning test Contextual fear, cued fear during nicotine withdrawal. Nicotine (high and several lower doses) vs. control.
Mice: inbred   8 strains   ♂   age 8-12wks   4 cohorts