MPD: Project measures / variables set: Gould3 EPM_pct

Project measures / variables set: Gould3 EPM_pct_open

ID, description, units	MPD:47326 EPM_pct_open withdrawal study group, percentage of time in open arms [%] nicotine study
Measures	• control • nicotine dose (mg) • 3 • 6.3 • 12
Data set, strains	Gould3 inbred 8 strains sex: m age: 8-12wks
Procedure	elevated plus maze
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0010471 exploratory behavior trait VT:0010716 anxiety-related behavior trait VT:0010721 response to nicotine trait VT:0010722 withdrawal response to addictive substance trait MP:0001362 abnormal anxiety-related response MP:0009774 abnormal behavioral withdrawal response MP:0013189 abnormal exploration in a new environment MP:0020160 abnormal behavioral response to nicotine

Values Means Δ Means Z-scores

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Gould3 - withdrawal study group, percentage of time in open arms

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	1953.3666	651.1222	2.5894	0.053
strain	7	89467.5789	12781.0827	50.8288	< 0.0001
dose:strain	21	7611.7769	362.4656	1.4415	0.0973
Residuals	302	75939.0445	251.4538

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould3	47326	elevated plus maze	nicotine	withdrawal study group, percentage of time in open arms [%] control EPM_pct_open_0	inbred	8	m	8-12wks
Gould3	47327	elevated plus maze	nicotine	withdrawal study group, percentage of time in open arms [%] dose: 3 mg EPM_pct_open_3	inbred	8	m	8-12wks
Gould3	47328	elevated plus maze	nicotine	withdrawal study group, percentage of time in open arms [%] dose: 6.3 mg EPM_pct_open_6	inbred	8	m	8-12wks
Gould3	47329	elevated plus maze	nicotine	withdrawal study group, percentage of time in open arms [%] dose: 12 mg EPM_pct_open_12	inbred	8	m	8-12wks