Gould4: Nicotine-induced conditioned place preference in 8 inbred strains of mice (2014)

Kutlu MG, Ortega LA, Gould TJ. Strain-dependent performance in nicotine-induced conditioned place preference. Behav Neurosci. 2015 Feb;129(1):37-4doi: 10.1037/bne0000029. Epub 2014 Dec 29.   PubMed 25546366  

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Participants Munir G Kutlu       Temple University Philadelphia, PA
Leonardo A Ortega       Temple University Philadelphia, PA
Thomas J Gould       Temple University Philadelphia, PA
ContactThomas J Gould     tgould@temple.edu
AcknowledgementsFunding provided by NIH DA017949
Project type Phenotype strain survey data set
MPD identifiersGould4     MPD:547
Data changelog No updates/corrections.       Initial release date: 05/2016.
Formatted citation
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The investigators used a conditioned place preference (CPP) paradigm to conduct an initial examination of the role of genetic background in the rewarding effects of nicotine. In the nicotine CPP procedure, some strains develop a preference for a chamber that is consistently paired with nicotine, which suggests that an association is made between the rewarding properties of nicotine and contextual stimuli. CPP training occurred in two phases with the first phase starting the day after the preconditioning session and consisted of three conditioning sessions (days 2-4). The first testing day was on day 5. The second phase of CPP training started on day 6 where mice underwent conditioning sessions on days 6-9. The second testing day was on day 10.

Summary of procedures that were conducted
• conditioned place preference test Nicotine preference and learning effect. Nicotine-treated vs. control. 2 trials (day 5, day 10).
Mice: inbred   8 strains   ♂   age 8-10wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Gould4 54701 conditioned place preference test nicotine preference trial 1   [s]     control    nicotine inbred 8 m 8-10wks N=9
    Gould4 54711 conditioned place preference test nicotine preference trial 2   [s]     control    nicotine inbred 8 m 8-10wks N=9
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