Paigen2: Diet effects on plasma lipids and susceptibility to atherosclerosis in 43 inbred strains of mice on high-fat atherogenic diet (under pathogen-free conditions) (2002)

Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.   PubMed 17317875  

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Investigators Beverly Paigen       The Jackson Laboratory,  Bar Harbor, ME
Karen L Svenson       The Jackson Laboratory,  Bar Harbor, ME
Luanne L Peters       The Jackson Laboratory,  Bar Harbor, ME
Participants Von Smith R
ContactBeverly Paigen
Affiliated CenterJAX Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by NIH HL66611

In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersPaigen2     MPD:99
Data changelog 4 updates/corrections.       Initial release date: 05/2003.
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Animals were evaluated at baseline and then again after 17 wks on high fat (15% fat) diet.

Procedures conducted:
• histopathology  Aortic lesion size histopathology. Baseline vs. high-fat diet (17wks).
• lipid profile  Cholesterol, HDL, non-HDL, triglycerides. Baseline vs. high-fat diet (17wks). 4h fast, plasma.

Mice: inbred w/CC7   43 strains   ♀♂   age 7-9wks, 24-27wks   1 experimental group