Naggert1: Diet effects on bone mineral density and content, body composition, and plasma glucose, leptin, and insulin levels in 43 inbred strains of mice on a high-fat atherogenic diet (2003)

Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.   PubMed 17317875  

Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29.   PubMed 18230669  


       
Naggert1 downloads
• Download Naggert1 project data set     one row per animal, one column per trait
• Download Naggert1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Jürgen Naggert       The Jackson Laboratory Bar Harbor, ME
Karen L Svenson       The Jackson Laboratory Bar Harbor, ME
Randy V Smith       The Jackson Laboratory Bar Harbor, ME
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Luanne L Peters       The Jackson Laboratory Bar Harbor, ME
ContactJürgen Naggert     jkn@jax.org
AffiliationJAX Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by NIH Program for Genomic Applications (PGA) HL66611.

In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersNaggert1     MPD:143
Data changelog 6 updates/corrections.       Initial release date: 05/2003.
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Summary of procedures that were conducted
• body weight High-fat diet for 8wks.
• DXA Body mass, fat mass, lean mass, bone mineral density and content. High-fat diet.
• metabolic panel Glucose (plasma). Baseline vs. high-fat diet (17wks). 4h fast.
• hormone quantification Insulin and leptin, after 18wks on high-fat diet. Multiple readings per animal were averaged.
Mice: inbred   43 strains   ♀♂   age 5, 21 wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Naggert1 14302 metabolic panel high-fat diet glucose (plasma GLU, 4h fast)   [mg/dL]     baseline    after 17wks on diet    Δchange inbred w/CC7 43 both 7-9wks N=10
    Naggert1 14305 hormone quantification high-fat diet insulin   [ng/mL]  INS_fat18 inbred w/CC7 42 both 25-27wks N=12
    Naggert1 14306 hormone quantification high-fat diet leptin   [pg/mL]  LEP_fat18 inbred w/CC7 43 both 25-27wks N=11
    Naggert1 14308 body weight high-fat diet body weight   [g]  bw_fat8 inbred w/CC7 39 both 15-17wks N=10
    Naggert1 14312 DXA high-fat diet bone mineral density (BMD)   [g/cm2]  BMD_fat8 inbred w/CC7 39 both 15-17wks N=10
    Naggert1 14314 DXA high-fat diet bone mineral content (BMC)   [g]  BMC_fat8 inbred w/CC7 39 both 15-17wks N=10
    Naggert1 14316 DXA high-fat diet total tissue mass, head excluded   [g]  tissuemass_fat8 inbred w/CC7 39 both 15-17wks N=10
    Naggert1 14317 DXA high-fat diet weight of fat portion of tissue mass, head excluded   [g]  fatwt_fat8 inbred w/CC7 39 both 15-17wks N=10
    Naggert1 14318 DXA high-fat diet weight of lean portion of tissue mass, head excluded   [g]  leanwt_fat8 inbred w/CC7 39 both 15-17wks N=10
    Naggert1 14319 DXA high-fat diet percent of tissue mass that is fat, head excluded   [%]  pctfat_fat8 inbred w/CC7 39 both 15-17wks N=10
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