Naggert1: Diet effects on bone mineral density and content, body composition, and plasma glucose, leptin, and insulin levels in 43 inbred strains of mice on a high-fat atherogenic diet (2003)

Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.   PubMed 17317875  

Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29.   PubMed 18230669  


       
Naggert1 downloads
• Download Naggert1 project data set     one row per animal, one column per trait
• Download Naggert1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Jürgen Naggert       The Jackson Laboratory Bar Harbor, ME
Karen L Svenson       The Jackson Laboratory Bar Harbor, ME
Randy V Smith       The Jackson Laboratory Bar Harbor, ME
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Luanne L Peters       The Jackson Laboratory Bar Harbor, ME
ContactJürgen Naggert     jkn@jax.org
AffiliationJAX Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by NIH Program for Genomic Applications (PGA) HL66611.

In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersNaggert1     MPD:143
Data changelog 6 updates/corrections.       Initial release date: 05/2003.
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Summary of procedures that were conducted
• body weight High-fat diet for 8wks.
• DXA Body mass, fat mass, lean mass, bone mineral density and content after 8wks on high-fat diet.
• metabolic panel Glucose (plasma). Baseline vs. high-fat diet (17wks). 4h fast.
• hormone quantification Insulin and leptin after 18wks on high-fat diet. Multiple readings per animal were averaged.
Mice: inbred w/CC7   43 strains   ♀♂   age 5, 21 wks   1 cohort