Schwartz2: Survey of ovalbumin-induced lung inflammatory changes in males of 8 inbred strains of mice (2001)

Whitehead GS, Walker JK, Berman KG, Foster WM, Schwartz DA. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L32-42. Epub 2003 Mar 07.   PubMed 12626335  


       
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Participants David A Schwartz       Duke University Chapel Hill, NC
Katherine G Berman       Duke University Chapel Hill, NC
Gregory S Whitehead       Duke University Chapel Hill, NC
Julia K Walker       Duke University Chapel Hill, NC
With: Walker JKL, Foster WM
ContactDavid A Schwartz     schwa021@mc.duke.edu
AffiliationJAX Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by Program for Genomic Applications (PGA) HL66611, HL66604
Project type Phenotype strain survey data set
MPD identifiersSchwartz2     MPD:98
Data changelog 2 updates/corrections.       Initial release date: 11/2004.
Formatted citation
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There are two cohorts both challenged with either increasing doses of methacholine (0, 5, 10, 20 mg/mL in saline) or aerosolized ovalbumin in 1% saline: (1) controls with aluminum hydroxide as adjuvant i.p.; (2) sensitized with ovalbumin as adjuvant.

Summary of procedures that were conducted
• bronchoalveolar lavage assessment Lung inflammatory changes. Ovalbumin vs. control.
Mice: inbred   8 strains   ♂   age 6-8wks   2 cohorts

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schwartz2 9801 bronchoalveolar lavage assessment ovalbumin alveolar eosinophils (percent of total lavage cells), pre-challenge   [%]     pre-test:    control    OVA-sensitized inbred 8 m 6-8wks N=3
    Schwartz2 9802 bronchoalveolar lavage assessment ovalbumin alveolar eosinophils (percent of total lavage cells), 24h post-challenge   [%]     24h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9803 bronchoalveolar lavage assessment ovalbumin alveolar eosinophils (percent of total lavage cells), 48h post-challenge   [%]     48h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9804 bronchoalveolar lavage assessment ovalbumin alveolar eosinophils (percent of total lavage cells), 72h post-challenge   [%]     72h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9821 bronchoalveolar lavage assessment ovalbumin alveolar lymphocytes (percent of total lavage cells), pre-challenge   [%]     pre-test:    control    OVA-sensitized inbred 8 m 6-8wks N=3
    Schwartz2 9822 bronchoalveolar lavage assessment ovalbumin alveolar lymphocytes (percent of total lavage cells), 24h post-challenge   [%]     24h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9823 bronchoalveolar lavage assessment ovalbumin alveolar lymphocytes (percent of total lavage cells), 48h post-challenge   [%]     48h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9824 bronchoalveolar lavage assessment ovalbumin alveolar lymphocytes (percent of total lavage cells), 72h post-challenge   [%]     72h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9841 bronchoalveolar lavage assessment ovalbumin alveolar neutrophils (percent of total lavage cells), pre-challenge   [%]     pre-test:    control    OVA-sensitized inbred 8 m 6-8wks N=3
    Schwartz2 9842 bronchoalveolar lavage assessment ovalbumin alveolar neutrophils (percent of total lavage cells), 24h post-challenge   [%]     24h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9843 bronchoalveolar lavage assessment ovalbumin alveolar neutrophils (percent of total lavage cells), 48h post-challenge   [%]     48h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
    Schwartz2 9844 bronchoalveolar lavage assessment ovalbumin alveolar neutrophils (percent of total lavage cells), 72h post-challenge   [%]     72h post:    control    OVA-sensitized inbred 8 m 6-8wks N=5
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