Schwartz2: Survey of ovalbumin-induced lung inflammatory changes in males of 8 inbred strains of mice (2001)

Whitehead GS, Walker JK, Berman KG, Foster WM, Schwartz DA. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L32-42. Epub 2003 Mar 07.   PubMed 12626335  


         
There are two cohorts both challenged with either increasing doses of methacholine (0, 5, 10, 20 mg/mL in saline) or aerosolized ovalbumin in 1% saline: (1) controls with aluminum hydroxide as adjuvant i.p.; (2) sensitized with ovalbumin as adjuvant.

Procedures conducted:
• bronchoalveolar lavage assessment  Lung inflammatory changes. Ovalbumin vs. control.

Schwartz2 downloads
• Download Schwartz2 project data set     animal data, as uploaded
• Download Schwartz2 animal data matrix     with factor-related expansion applied as necessary
• Download Schwartz2 strain means, SD, N, etc.     one row per strain/sex/measure
• Schwartz2 supplementary data
Investigators David A Schwartz       Duke University,  Chapel Hill, NC
Katherine G Berman       Duke University,  Chapel Hill, NC
Gregory S Whitehead       Duke University,  Chapel Hill, NC
Julia K Walker       Duke University,  Chapel Hill, NC
Participants Walker JKL, Foster WM
ContactDavid A Schwartz     schwa021@mc.duke.edu
Affiliated CenterJAX Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by Program for Genomic Applications (PGA) HL66611, HL66604
Project type Phenotype strain survey data set
MPD identifiersSchwartz2     MPD:98
Data changelog 2 updates/corrections.       Initial release date: 11/2004.
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Mice: inbred   8 strains   ♂   age 6-8wks   2 experimental groups