Phenotype measures set:   Thomsen2   activ_D1

ID, description, units MPD:40801   activ_D1   total activity, dose response to D1 agonist, 3h test   [n]
R-6-Br-APB study
Measures • baseline    • dose mg/kg i.p.    • 0.03    • 0.32    • 3.2    • 5.6
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
Comparisonrepeated measures, baseline then treated multiple doses, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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  OVERLAPPING STRAIN CURVES
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Thomsen2 - total activity, dose response to D1 agonist, 3h test





  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   sex 1 59253.7922 59253.7922 0.0136 0.9072
between   strain 8 818269983.686 102283747.9608 23.5513 < 0.0001
between   sex:strain 8 164806700.1467 20600837.5183 4.7434 < 0.0001
between   Residuals 114 495105128.3024 4343027.4412
within   dose 4 563167255.6515 140791813.9129 74.0132 < 0.0001
within   dose:sex 4 30956292.7275 7739073.1819 4.0684 0.003
within   dose:strain 32 851168605.2884 26599018.9153 13.9829 < 0.0001
within   dose:sex:strain 32 164164035.3564 5130126.1049 2.6969 < 0.0001
within   Residuals 456 867427205.7762 1902252.6442

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDDrug or
challenge
Description and varname PanelStrains
tested
SexAge
Thomsen2 40801 open field test R-6-Br-APB total activity, dose response to D1 agonist, 3h test   [n]   baseline   activ_D1_0 inbred 15 both 8-10wks
Thomsen2 40802 open field test R-6-Br-APB total activity, dose response to D1 agonist, 3h test   [n]   dose 0.03 mg/kg   activ_D1_doseA inbred 15 both 8-10wks
Thomsen2 40803 open field test R-6-Br-APB total activity, dose response to D1 agonist, 3h test   [n]   dose 0.32 mg/kg   activ_D1_doseB inbred 15 both 8-10wks
Thomsen2 40804 open field test R-6-Br-APB total activity, dose response to D1 agonist, 3h test   [n]   dose 3.2 mg/kg   activ_D1_doseC inbred 15 both 8-10wks
Thomsen2 40805 open field test R-6-Br-APB total activity, dose response to D1 agonist, 3h test   [n]   dose 5.6 mg/kg   activ_D1_doseD inbred 11 both 8-10wks