Phenotype measure:   Thomsen2   activ_D1_doseB


  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D1 agonist, 3h test dose 0.32 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means3086   n 2986   n
Median of the strain means2673   n 3232   n
SD of the strain means± 1586 ± 1084
Coefficient of variation (CV)0.514 0.363
Min–max range of strain means1168   –   6751   n 1464   –   5584   n
Mean sample size per strain7.8   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 960000.2489 960000.2489 0.5997 0.4396
strain 14 310219725.8012 22158551.8429 13.8426 < 0.0001
sex:strain 14 88126326.214 6294737.5867 3.9324 < 0.0001
Residuals 198 316949060.6964 1600752.8318


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 2673.0 638.0   8 226.0 0.239 1735.0, 3426.0 -0.26
129S1/SvImJ m 3626.0 1697.0   8 600.0 0.468 745.0, 6273.0 0.59
129S6/SvEvTac f 1690.0 902.0   8 319.0 0.533 991.0, 3763.0 -0.88
129S6/SvEvTac m 1983.0 786.0   8 278.0 0.396 1257.0, 3610.0 -0.93
129X1/SvJ f 1865.0 894.0   8 316.0 0.479 198.0, 2827.0 -0.77
129X1/SvJ m 3334.0 1065.0   8 376.0 0.319 1640.0, 4785.0 0.32
A/J f 1466.0 623.0   7 235.0 0.425 748.0, 2675.0 -1.02
A/J m 1740.0 1187.0   7 449.0 0.683 931.0, 4240.0 -1.15
BALB/cByJ f 4951.0 1806.0   7 682.0 0.365 3319.0, 7864.0 1.18
BALB/cByJ m 3411.0 1358.0   8 480.0 0.398 1807.0, 5685.0 0.39
BALB/cJ f 4056.0 798.0   8 282.0 0.197 2963.0, 5247.0 0.61
BALB/cJ m 5584.0 1165.0   8 412.0 0.209 3283.0, 6749.0 2.4
C3H/HeJ f 1168.0 400.0   8 141.0 0.342 348.0, 1541.0 -1.21
C3H/HeJ m 1914.0 573.0   8 203.0 0.299 1083.0, 2789.0 -0.99
C57BL/6J f 3689.0 910.0   8 322.0 0.247 1651.0, 4555.0 0.38
C57BL/6J m 2889.0 1791.0   7 677.0 0.62 403.0, 5190.0 -0.09
CAST/EiJ f 4572.0 986.0   8 349.0 0.216 2476.0, 5618.0 0.94
CAST/EiJ m 3711.0 2402.0   4 1201.0 0.647 1284.0, 6024.0 0.67
Crl:CD-1(ICR) f 3507.0 2603.0   8 920.0 0.742 222.0, 6741.0 0.27
Crl:CD-1(ICR) m 3862.0 1334.0   8 472.0 0.345 2093.0, 5869.0 0.81
DBA/2J f 2000.0 470.0   7 178.0 0.235 1102.0, 2444.0 -0.68
DBA/2J m 2819.0 1694.0   8 599.0 0.601 595.0, 6240.0 -0.15
FVB/NJ f 6751.0 1851.0   8 655.0 0.274 4214.0, 9577.0 2.31
FVB/NJ m 3420.0 1253.0   8 443.0 0.366 1564.0, 5886.0 0.4
SJL/J f 1915.0 924.0   8 327.0 0.483 737.0, 3685.0 -0.74
SJL/J m 1464.0 610.0   8 216.0 0.417 450.0, 2093.0 -1.4
SPRET/EiJ f 1962.0 1368.0   6 558.0 0.697 771.0, 4616.0 -0.71
SPRET/EiJ m 1807.0 975.0   7 368.0 0.539 785.0, 3511.0 -1.09
Tac:SW f 4025.0 1383.0   8 489.0 0.344 2355.0, 5977.0 0.59
Tac:SW m 3232.0 1023.0   8 362.0 0.317 2000.0, 4936.0 0.23


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 2673.0 447.3188 3555.1205 1790.8795
129S1/SvImJ m 3626.25 447.3188 4508.3705 2744.1295
129S6/SvEvTac f 1690.25 447.3188 2572.3705 808.1295
129S6/SvEvTac m 1983.0 447.3188 2865.1205 1100.8795
129X1/SvJ f 1865.25 447.3188 2747.3705 983.1295
129X1/SvJ m 3334.5 447.3188 4216.6205 2452.3795
A/J f 1466.1429 478.2039 2409.1693 523.1164
A/J m 1739.8571 478.2039 2682.8836 796.8307
BALB/cByJ f 4950.8571 478.2039 5893.8836 4007.8307
BALB/cByJ m 3411.25 447.3188 4293.3705 2529.1295
BALB/cJ f 4055.625 447.3188 4937.7455 3173.5045
BALB/cJ m 5583.625 447.3188 6465.7455 4701.5045
C3H/HeJ f 1168.125 447.3188 2050.2455 286.0045
C3H/HeJ m 1914.375 447.3188 2796.4955 1032.2545
C57BL/6J f 3689.25 447.3188 4571.3705 2807.1295
C57BL/6J m 2888.5714 478.2039 3831.5979 1945.545
CAST/EiJ f 4571.625 447.3188 5453.7455 3689.5045
CAST/EiJ m 3711.25 632.6043 4958.7567 2463.7433
Crl:CD-1(ICR) f 3507.0 447.3188 4389.1205 2624.8795
Crl:CD-1(ICR) m 3862.0 447.3188 4744.1205 2979.8795
DBA/2J f 1999.7143 478.2039 2942.7407 1056.6878
DBA/2J m 2818.875 447.3188 3700.9955 1936.7545
FVB/NJ f 6751.125 447.3188 7633.2455 5869.0045
FVB/NJ m 3419.5 447.3188 4301.6205 2537.3795
SJL/J f 1914.75 447.3188 2796.8705 1032.6295
SJL/J m 1463.5 447.3188 2345.6205 581.3795
SPRET/EiJ f 1961.5 516.5193 2980.085 942.915
SPRET/EiJ m 1807.1429 478.2039 2750.1693 864.1164
Tac:SW f 4024.875 447.3188 4906.9955 3142.7545
Tac:SW m 3231.625 447.3188 4113.7455 2349.5045


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3149.625 316.3022 3773.3784 2525.8716
129S6/SvEvTac both 1836.625 316.3022 2460.3784 1212.8716
129X1/SvJ both 2599.875 316.3022 3223.6284 1976.1216
A/J both 1603.0 338.1412 2269.8204 936.1796
BALB/cByJ both 4181.0536 327.4038 4826.6997 3535.4075
BALB/cJ both 4819.625 316.3022 5443.3784 4195.8716
C3H/HeJ both 1541.25 316.3022 2165.0034 917.4966
C57BL/6J both 3288.9107 327.4038 3934.5568 2643.2646
CAST/EiJ both 4141.4375 387.3894 4905.3762 3377.4988
Crl:CD-1(ICR) both 3684.5 316.3022 4308.2534 3060.7466
DBA/2J both 2409.2946 327.4038 3054.9407 1763.6486
FVB/NJ both 5085.3125 316.3022 5709.0659 4461.5591
SJL/J both 1689.125 316.3022 2312.8784 1065.3716
SPRET/EiJ both 1884.3214 351.9485 2578.3701 1190.2727
Tac:SW both 3628.25 316.3022 4252.0034 3004.4966




  GWAS USING LINEAR MIXED MODELS