Project measure / variable:   Thomsen2   activ_D1_doseD

ID, description, units MPD:40805   activ_D1_doseD   total activity, dose response to D1 agonist, 3h test   [n]  dose 5.6 mg/kg  
R-6-Br-APB study
Data set, strains Thomsen2   inbred   11 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D1 agonist, 3h test dose 5.6 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means3778   n 3654   n
Median of the strain means2630   n 3171   n
SD of the strain means± 2295 ± 1481
Coefficient of variation (CV)0.607 0.405
Min–max range of strain means1466   –   7537   n 1568   –   6590   n
Mean sample size per strain7.0   mice 7.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 297057.0932 297057.0932 0.0672 0.7959
strain 8 395504806.0277 49438100.7535 11.1905 < 0.0001
sex:strain 8 41186357.347 5148294.6684 1.1653 0.3261
Residuals 115 508054376.1036 4417864.14


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 3146.0 3181.0   4 1590.0 1.01 904.0, 7862.0 -0.34
129S6/SvEvTac f 2307.0 1269.0   8 449.0 0.55 1164.0, 4786.0 -0.64
129S6/SvEvTac m 2864.0 1337.0   8 473.0 0.467 1559.0, 5388.0 -0.53
A/J f 1466.0 511.0   6 209.0 0.349 1001.0, 2368.0 -1.01
A/J m 1568.0 596.0   7 225.0 0.38 810.0, 2352.0 -1.41
BALB/cByJ f 2603.0 1162.0   7 439.0 0.446 1607.0, 4950.0 -0.51
BALB/cByJ m 2559.0 558.0   8 197.0 0.218 1617.0, 3579.0 -0.74
BALB/cJ f 2657.0 862.0   8 305.0 0.324 1208.0, 3597.0 -0.49
BALB/cJ m 3645.0 1184.0   8 418.0 0.325 2260.0, 5733.0 -0.01
C3H/HeJ f 1718.0 988.0   8 349.0 0.575 488.0, 3546.0 -0.9
C3H/HeJ m 2946.0 1363.0   8 482.0 0.463 2000.0, 5671.0 -0.48
Crl:CD-1(ICR) f 7318.0 2069.0   7 782.0 0.283 4569.0, 11106.0 1.54
Crl:CD-1(ICR) m 6590.0 5282.0   8 1867.0 0.802 1449.0, 18460.0 1.98
FVB/NJ f 2241.0 549.0   4 275.0 0.245 1707.0, 2738.0 -0.67
SJL/J f 4206.0 4879.0   8 1725.0 1.16 1398.0, 16117.0 0.19
SJL/J m 3196.0 619.0   8 219.0 0.194 1959.0, 3819.0 -0.31
SPRET/EiJ f 7537.0 1911.0   5 854.0 0.253 5029.0, 9724.0 1.64
SPRET/EiJ m 4652.0 1142.0   7 431.0 0.245 3244.0, 6213.0 0.67
Tac:SW f 5726.0 1448.0   7 547.0 0.253 3649.0, 7638.0 0.85
Tac:SW m 5377.0 1320.0   7 499.0 0.245 3309.0, 7061.0 1.16


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S6/SvEvTac f 2306.875 743.1238 3778.8603 834.8897
129S6/SvEvTac m 2863.875 743.1238 4335.8603 1391.8897
A/J f 1466.0 858.0855 3165.7022 0.0
A/J m 1568.0 794.4328 3141.6184 0.0
BALB/cByJ f 2602.7143 794.4328 4176.3327 1029.0958
BALB/cByJ m 2558.875 743.1238 4030.8603 1086.8897
BALB/cJ f 2656.75 743.1238 4128.7353 1184.7647
BALB/cJ m 3645.125 743.1238 5117.1103 2173.1397
C3H/HeJ f 1718.0 743.1238 3189.9853 246.0147
C3H/HeJ m 2945.75 743.1238 4417.7353 1473.7647
Crl:CD-1(ICR) f 7317.7143 794.4328 8891.3327 5744.0958
Crl:CD-1(ICR) m 6589.75 743.1238 8061.7353 5117.7647
SJL/J f 4205.5 743.1238 5677.4853 2733.5147
SJL/J m 3195.625 743.1238 4667.6103 1723.6397
SPRET/EiJ f 7536.8 939.9855 9398.7305 5674.8695
SPRET/EiJ m 4651.5714 794.4328 6225.1899 3077.953
Tac:SW f 5726.2857 794.4328 7299.9042 4152.6673
Tac:SW m 5377.2857 794.4328 6950.9042 3803.6673


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S6/SvEvTac both 2585.375 525.4679 3626.2258 1544.5242
A/J both 1517.0 584.6867 2675.1518 358.8482
BALB/cByJ both 2580.7946 543.9109 3658.1775 1503.4117
BALB/cJ both 3150.9375 525.4679 4191.7883 2110.0867
C3H/HeJ both 2331.875 525.4679 3372.7258 1291.0242
Crl:CD-1(ICR) both 6953.7321 543.9109 8031.115 5876.3492
SJL/J both 3700.5625 525.4679 4741.4133 2659.7117
SPRET/EiJ both 6094.1857 615.365 7313.1053 4875.2661
Tac:SW both 5551.7857 561.7488 6664.502 4439.0694




  GWAS USING LINEAR MIXED MODELS