Thomsen2: Drug study: Psychomotor response to dopamine agonists in 15 mouse strains (2011)

Thomsen M, Ralph RJ, Caine SB. Psychomotor stimulation by dopamine D₁-like but not D₂-like agonists in most mouse strains. Exp Clin Psychopharmacol. 2011 Oct;19(5):342-60.   PubMed 21843011  


       
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Participants Morgane Thomsen       Harvard Medical School Boston, MA
S Barak Caine       Harvard Medical School Boston, MA
ContactMorgane Thomsen     mthomsen@mclean.harvard.edu     Lab web site
Part of a series: • cocaine study   see Thomsen1
• dopamine agonists study   (this project) Thomsen2
AcknowledgementsFunding provided by NIH DA07252, DA12142
Project type Phenotype strain survey data set
MPD identifiersThomsen2     MPD:408
Data changelog No updates/corrections.       Initial release date: 06/2012.
Formatted citation
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Mice were evaluated for psychomotor effects of the dopamine D1-like agonist R-6-Br-APB and the dopamine D2-like agonist quinelorane, both at four different doses, using a locomotor activity procedure.

Summary of procedures that were conducted
• open field test Locomotor activity. Baseline (saline) vs. dopamine agonists i.p. (several doses). 3h session.
Mice: inbred   15 strains   ♀♂   age 8-10wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Thomsen2 40801 open field test R-6-Br-APB total activity, dose response to D1 agonist   [n]     baseline    dose mg/kg i.p.    0.03    0.32    3.2    5.6 inbred 15 both 8-10wks N=8
    Thomsen2 40806 open field test quinelorane total activity, dose response to D2 agonist   [n]     baseline    dose mg/kg i.p.    0.03    0.32    3.2    5.6 inbred 15 both 8-10wks N=8
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