Phenotype measure:   Thomsen2   activ_D1_doseA


  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D1 agonist, 3h test dose 0.03 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2450   n 1837   n
Median of the strain means1102   n 1414   n
SD of the strain means± 2339 ± 1571
Coefficient of variation (CV)0.954 0.855
Min–max range of strain means290   –   8688   n 240   –   5951   n
Mean sample size per strain7.7   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 28087020.0702 28087020.0702 19.0902 < 0.0001
strain 14 669543875.1816 47824562.513 32.5055 < 0.0001
sex:strain 14 180101942.8745 12864424.491 8.7437 < 0.0001
Residuals 198 291312936.8036 1471277.4586


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 515.0 133.0   8 47.0 0.258 341.0, 658.0 -0.83
129S1/SvImJ m 896.0 542.0   8 192.0 0.604 89.0, 1558.0 -0.6
129S6/SvEvTac f 333.0 188.0   8 66.4 0.564 74.0, 628.0 -0.91
129S6/SvEvTac m 360.0 246.0   8 87.1 0.685 137.0, 868.0 -0.94
129X1/SvJ f 290.0 155.0   8 54.8 0.534 140.0, 552.0 -0.92
129X1/SvJ m 240.0 146.0   8 51.8 0.611 43.0, 466.0 -1.02
A/J f 905.0 506.0   7 191.0 0.558 462.0, 1678.0 -0.66
A/J m 1373.0 606.0   7 229.0 0.442 481.0, 2247.0 -0.3
BALB/cByJ f 4737.0 1875.0   7 709.0 0.396 2225.0, 7461.0 0.98
BALB/cByJ m 1258.0 793.0   8 280.0 0.631 413.0, 2223.0 -0.37
BALB/cJ f 4366.0 1994.0   8 705.0 0.457 809.0, 7109.0 0.82
BALB/cJ m 5951.0 1196.0   8 423.0 0.201 4285.0, 8200.0 2.62
C3H/HeJ f 550.0 194.0   8 68.5 0.353 351.0, 856.0 -0.81
C3H/HeJ m 1663.0 619.0   8 219.0 0.372 922.0, 2720.0 -0.11
C57BL/6J f 3550.0 1093.0   8 386.0 0.308 1896.0, 5081.0 0.47
C57BL/6J m 1767.0 545.0   8 193.0 0.308 1058.0, 2878.0 -0.04
CAST/EiJ f 3451.0 2054.0   7 776.0 0.595 859.0, 6097.0 0.43
CAST/EiJ m 4215.0 1676.0   4 838.0 0.398 2945.0, 6522.0 1.51
Crl:CD-1(ICR) f 2440.0 2364.0   8 836.0 0.969 368.0, 6021.0 0.0
Crl:CD-1(ICR) m 1854.0 1603.0   8 567.0 0.865 493.0, 4955.0 0.01
DBA/2J f 1058.0 566.0   7 214.0 0.535 438.0, 1796.0 -0.6
DBA/2J m 1414.0 732.0   8 259.0 0.518 426.0, 2626.0 -0.27
FVB/NJ f 8688.0 1485.0   8 525.0 0.171 7092.0, 11642.0 2.67
FVB/NJ m 3578.0 2739.0   8 968.0 0.765 512.0, 7926.0 1.11
SJL/J f 989.0 502.0   8 177.0 0.507 464.0, 2009.0 -0.62
SJL/J m 934.0 574.0   8 203.0 0.614 355.0, 1670.0 -0.58
SPRET/EiJ f 1102.0 469.0   6 191.0 0.425 637.0, 1828.0 -0.58
SPRET/EiJ m 573.0 254.0   7 96.1 0.444 292.0, 954.0 -0.8
Tac:SW f 3779.0 2053.0   8 726.0 0.543 1217.0, 8034.0 0.57
Tac:SW m 1481.0 1083.0   8 383.0 0.731 466.0, 3536.0 -0.23


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 515.125 428.8469 1360.8186 0.0
129S1/SvImJ m 896.5 428.8469 1742.1936 50.8064
129S6/SvEvTac f 333.375 428.8469 1179.0686 0.0
129S6/SvEvTac m 359.75 428.8469 1205.4436 0.0
129X1/SvJ f 290.375 428.8469 1136.0686 0.0
129X1/SvJ m 239.75 428.8469 1085.4436 0.0
A/J f 905.4286 458.4566 1809.5131 1.3441
A/J m 1372.5714 458.4566 2276.6559 468.4869
BALB/cByJ f 4737.0 458.4566 5641.0845 3832.9155
BALB/cByJ m 1257.625 428.8469 2103.3186 411.9314
BALB/cJ f 4366.375 428.8469 5212.0686 3520.6814
BALB/cJ m 5951.375 428.8469 6797.0686 5105.6814
C3H/HeJ f 549.5 428.8469 1395.1936 0.0
C3H/HeJ m 1663.125 428.8469 2508.8186 817.4314
C57BL/6J f 3549.625 428.8469 4395.3186 2703.9314
C57BL/6J m 1767.375 428.8469 2613.0686 921.6814
CAST/EiJ f 3451.2857 458.4566 4355.3702 2547.2012
CAST/EiJ m 4215.25 606.4811 5411.2414 3019.2586
Crl:CD-1(ICR) f 2439.5 428.8469 3285.1936 1593.8064
Crl:CD-1(ICR) m 1854.125 428.8469 2699.8186 1008.4314
DBA/2J f 1058.4286 458.4566 1962.5131 154.3441
DBA/2J m 1414.0 428.8469 2259.6936 568.3064
FVB/NJ f 8688.0 428.8469 9533.6936 7842.3064
FVB/NJ m 3578.125 428.8469 4423.8186 2732.4314
SJL/J f 988.625 428.8469 1834.3186 142.9314
SJL/J m 934.125 428.8469 1779.8186 88.4314
SPRET/EiJ f 1102.5 495.1898 2079.0229 125.9771
SPRET/EiJ m 572.8571 458.4566 1476.9417 0.0
Tac:SW f 3778.875 428.8469 4624.5686 2933.1814
Tac:SW m 1480.625 428.8469 2326.3186 634.9314


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 705.8125 303.2406 1303.8082 107.8168
129S6/SvEvTac both 346.5625 303.2406 944.5582 0.0
129X1/SvJ both 265.0625 303.2406 863.0582 0.0
A/J both 1139.0 324.1778 1778.2843 499.7157
BALB/cByJ both 2997.3125 313.8838 3616.2969 2378.3281
BALB/cJ both 5158.875 303.2406 5756.8707 4560.8793
C3H/HeJ both 1106.3125 303.2406 1704.3082 508.3168
C57BL/6J both 2658.5 303.2406 3256.4957 2060.5043
CAST/EiJ both 3833.2679 380.1322 4582.8951 3083.6406
Crl:CD-1(ICR) both 2146.8125 303.2406 2744.8082 1548.8168
DBA/2J both 1236.2143 313.8838 1855.1986 617.2299
FVB/NJ both 6133.0625 303.2406 6731.0582 5535.0668
SJL/J both 961.375 303.2406 1559.3707 363.3793
SPRET/EiJ both 837.6786 337.415 1503.0668 172.2904
Tac:SW both 2629.75 303.2406 3227.7457 2031.7543




  GWAS USING LINEAR MIXED MODELS