Phenotype measure:   Thomsen2   activ_D1_0


  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D1 agonist, 3h test baseline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2599   n 1895   n
Median of the strain means1234   n 1481   n
SD of the strain means± 2579 ± 1667
Coefficient of variation (CV)0.993 0.880
Min–max range of strain means246   –   9131   n 327   –   6068   n
Mean sample size per strain7.7   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 30898019.6886 30898019.6886 18.6021 < 0.0001
strain 14 862478250.6373 61605589.3312 37.0896 < 0.0001
sex:strain 14 148718264.555 10622733.1825 6.3954 < 0.0001
Residuals 198 328876887.869 1660994.3832


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 529.0 185.0   8 65.3 0.349 316.0, 793.0 -0.8
129S1/SvImJ m 569.0 273.0   8 96.4 0.479 141.0, 963.0 -0.8
129S6/SvEvTac f 394.0 210.0   8 74.2 0.533 122.0, 804.0 -0.85
129S6/SvEvTac m 387.0 195.0   8 69.0 0.504 21.0, 719.0 -0.9
129X1/SvJ f 246.0 85.4   8 30.2 0.347 133.0, 357.0 -0.91
129X1/SvJ m 327.0 210.0   8 74.3 0.643 82.0, 746.0 -0.94
A/J f 1050.0 621.0   8 219.0 0.591 54.0, 2146.0 -0.6
A/J m 1481.0 481.0   7 182.0 0.324 698.0, 2045.0 -0.25
BALB/cByJ f 5321.0 1601.0   7 605.0 0.301 3088.0, 7229.0 1.06
BALB/cByJ m 2253.0 1784.0   8 631.0 0.792 269.0, 4362.0 0.21
BALB/cJ f 5013.0 944.0   8 334.0 0.188 3651.0, 6323.0 0.94
BALB/cJ m 6068.0 1673.0   8 591.0 0.276 3261.0, 8693.0 2.5
C3H/HeJ f 769.0 349.0   8 123.0 0.454 405.0, 1469.0 -0.71
C3H/HeJ m 1784.0 975.0   8 345.0 0.546 632.0, 3226.0 -0.07
C57BL/6J f 2176.0 857.0   8 303.0 0.394 1152.0, 3740.0 -0.16
C57BL/6J m 1660.0 706.0   8 250.0 0.425 678.0, 2636.0 -0.14
CAST/EiJ f 4975.0 1702.0   6 695.0 0.342 2319.0, 7242.0 0.92
CAST/EiJ m 3808.0 1548.0   4 774.0 0.406 1763.0, 5480.0 1.15
Crl:CD-1(ICR) f 2348.0 2400.0   8 849.0 1.02 220.0, 6031.0 -0.1
Crl:CD-1(ICR) m 2043.0 2221.0   8 785.0 1.09 321.0, 6846.0 0.09
DBA/2J f 763.0 413.0   7 156.0 0.542 289.0, 1255.0 -0.71
DBA/2J m 1283.0 742.0   8 262.0 0.578 163.0, 2278.0 -0.37
FVB/NJ f 9131.0 1296.0   8 458.0 0.142 7802.0, 11963.0 2.53
FVB/NJ m 4454.0 2794.0   8 988.0 0.627 1115.0, 8963.0 1.53
SJL/J f 1234.0 704.0   8 249.0 0.57 455.0, 2747.0 -0.53
SJL/J m 658.0 312.0   8 110.0 0.474 260.0, 1206.0 -0.74
SPRET/EiJ f 832.0 271.0   6 111.0 0.326 425.0, 1226.0 -0.68
SPRET/EiJ m 486.0 169.0   7 63.7 0.347 318.0, 752.0 -0.85
Tac:SW f 4201.0 2992.0   8 1058.0 0.712 693.0, 8661.0 0.62
Tac:SW m 1167.0 1090.0   8 385.0 0.935 449.0, 3781.0 -0.44


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 529.25 455.6581 1427.8157 0.0
129S1/SvImJ m 569.0 455.6581 1467.5657 0.0
129S6/SvEvTac f 394.0 455.6581 1292.5657 0.0
129S6/SvEvTac m 386.875 455.6581 1285.4407 0.0
129X1/SvJ f 245.75 455.6581 1144.3157 0.0
129X1/SvJ m 326.875 455.6581 1225.4407 0.0
A/J f 1050.0 455.6581 1948.5657 151.4343
A/J m 1481.2857 487.119 2441.8929 520.6785
BALB/cByJ f 5320.5714 487.119 6281.1786 4359.9643
BALB/cByJ m 2253.0 455.6581 3151.5657 1354.4343
BALB/cJ f 5013.25 455.6581 5911.8157 4114.6843
BALB/cJ m 6068.5 455.6581 6967.0657 5169.9343
C3H/HeJ f 769.375 455.6581 1667.9407 0.0
C3H/HeJ m 1784.25 455.6581 2682.8157 885.6843
C57BL/6J f 2176.0 455.6581 3074.5657 1277.4343
C57BL/6J m 1660.0 455.6581 2558.5657 761.4343
CAST/EiJ f 4975.3333 526.1486 6012.9077 3937.759
CAST/EiJ m 3807.75 644.3979 5078.5138 2536.9862
Crl:CD-1(ICR) f 2348.0 455.6581 3246.5657 1449.4343
Crl:CD-1(ICR) m 2043.25 455.6581 2941.8157 1144.6843
DBA/2J f 762.5714 487.119 1723.1786 0.0
DBA/2J m 1283.125 455.6581 2181.6907 384.5593
FVB/NJ f 9131.25 455.6581 10029.8157 8232.6843
FVB/NJ m 4454.375 455.6581 5352.9407 3555.8093
SJL/J f 1233.5 455.6581 2132.0657 334.9343
SJL/J m 657.875 455.6581 1556.4407 0.0
SPRET/EiJ f 832.5 526.1486 1870.0743 0.0
SPRET/EiJ m 485.7143 487.119 1446.3215 0.0
Tac:SW f 4201.375 455.6581 5099.9407 3302.8093
Tac:SW m 1166.625 455.6581 2065.1907 268.0593


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 549.125 322.1989 1184.5069 0.0
129S6/SvEvTac both 390.4375 322.1989 1025.8194 0.0
129X1/SvJ both 286.3125 322.1989 921.6944 0.0
A/J both 1265.6429 333.5076 1923.3256 607.9601
BALB/cByJ both 3786.7857 333.5076 4444.4685 3129.1029
BALB/cJ both 5540.875 322.1989 6176.2569 4905.4931
C3H/HeJ both 1276.8125 322.1989 1912.1944 641.4306
C57BL/6J both 1918.0 322.1989 2553.3819 1282.6181
CAST/EiJ both 4391.5417 415.957 5211.8162 3571.2671
Crl:CD-1(ICR) both 2195.625 322.1989 2831.0069 1560.2431
DBA/2J both 1022.8482 333.5076 1680.531 365.1654
FVB/NJ both 6792.8125 322.1989 7428.1944 6157.4306
SJL/J both 945.6875 322.1989 1581.0694 310.3056
SPRET/EiJ both 659.1071 358.5099 1366.0949 0.0
Tac:SW both 2684.0 322.1989 3319.3819 2048.6181




  GWAS USING LINEAR MIXED MODELS