Phenotype measure:   Thomsen2   activ_D1_doseC


  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D1 agonist, 3h test dose 3.2 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means4349   n 4752   n
Median of the strain means3952   n 4433   n
SD of the strain means± 1528 ± 2478
Coefficient of variation (CV)0.351 0.521
Min–max range of strain means1904   –   6844   n 1622   –   10718   n
Mean sample size per strain7.8   mice 7.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 13427626.6798 13427626.6798 4.0394 0.0459
strain 13 757958093.5301 58304468.7331 17.5398 < 0.0001
sex:strain 13 142006498.7316 10923576.8255 3.2862 0.0002
Residuals 186 618287216.3155 3324124.8189


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 6838.0 1063.0   8 376.0 0.155 5083.0, 8610.0 1.63
129S1/SvImJ m 8436.0 2306.0   8 815.0 0.273 5423.0, 12275.0 1.49
129S6/SvEvTac f 4395.0 2686.0   8 950.0 0.611 873.0, 9308.0 0.03
129S6/SvEvTac m 5672.0 1128.0   8 399.0 0.199 4099.0, 7546.0 0.37
129X1/SvJ f 5670.0 1711.0   8 605.0 0.302 4141.0, 9469.0 0.86
129X1/SvJ m 6930.0 3597.0   8 1272.0 0.519 0.88
A/J f 1904.0 432.0   8 153.0 0.227 1375.0, 2465.0 -1.6
A/J m 1622.0 259.0   7 98.0 0.16 1233.0, 2056.0 -1.26
BALB/cByJ f 3326.0 1084.0   7 410.0 0.326 2337.0, 5353.0 -0.67
BALB/cByJ m 3095.0 490.0   8 173.0 0.158 2357.0, 3656.0 -0.67
BALB/cJ f 3570.0 1298.0   8 459.0 0.364 1855.0, 5638.0 -0.51
BALB/cJ m 4433.0 1917.0   8 678.0 0.432 1790.0, 6556.0 -0.13
C3H/HeJ f 2766.0 1276.0   8 451.0 0.461 1774.0, 5459.0 -1.04
C3H/HeJ m 2215.0 696.0   8 246.0 0.314 1114.0, 3398.0 -1.02
C57BL/6J f 3005.0 896.0   8 317.0 0.298 2113.0, 4654.0 -0.88
C57BL/6J m 2955.0 715.0   7 270.0 0.242 1641.0, 3946.0 -0.73
CAST/EiJ f 4061.0 3141.0   8 1110.0 0.773 658.0, 9665.0 -0.19
CAST/EiJ m 2768.0 1743.0   4 871.0 0.63 1087.0, 5211.0 -0.8
Crl:CD-1(ICR) f 5792.0 2682.0   8 948.0 0.463 145.0, 9083.0 0.94
Crl:CD-1(ICR) m 10718.0 3827.0   8 1353.0 0.357 6251.0, 16438.0 2.41
DBA/2J f 3625.0 2676.0   6 1092.0 0.738 1841.0, 9033.0 -0.47
DBA/2J m 4713.0 0.0   1   0.0 0.0 4713.0, 4713.0 -0.02
FVB/NJ f 6051.0 1055.0   8 373.0 0.174 4520.0, 7447.0 1.11
FVB/NJ m 4168.0 1379.0   8 488.0 0.331 2323.0, 5926.0 -0.24
SJL/J f 3438.0 987.0   8 349.0 0.287 1305.0, 4669.0 -0.6
SJL/J m 2886.0 1122.0   8 397.0 0.389 1504.0, 4740.0 -0.75
SPRET/EiJ f 6844.0 1433.0   6 585.0 0.209 5383.0, 9298.0 1.63
SPRET/EiJ m 5802.0 2371.0   7 896.0 0.409 2536.0, 8906.0 0.42
Tac:SW f 3952.0 1194.0   8 422.0 0.302 2662.0, 6034.0 -0.26
Tac:SW m 4860.0 1165.0   8 412.0 0.24 3489.0, 6434.0 0.04


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 6838.5 644.605 8110.1768 5566.8232
129S1/SvImJ m 8436.0 644.605 9707.6768 7164.3232
129S6/SvEvTac f 4394.875 644.605 5666.5518 3123.1982
129S6/SvEvTac m 5672.0 644.605 6943.6768 4400.3232
129X1/SvJ f 5669.5 644.605 6941.1768 4397.8232
129X1/SvJ m 6929.875 644.605 8201.5518 5658.1982
A/J f 1903.5 644.605 3175.1768 631.8232
A/J m 1621.8571 689.1117 2981.3368 262.3774
BALB/cByJ f 3325.7143 689.1117 4685.194 1966.2346
BALB/cByJ m 3095.375 644.605 4367.0518 1823.6982
BALB/cJ f 3570.375 644.605 4842.0518 2298.6982
BALB/cJ m 4433.125 644.605 5704.8018 3161.4482
C3H/HeJ f 2766.375 644.605 4038.0518 1494.6982
C3H/HeJ m 2215.0 644.605 3486.6768 943.3232
C57BL/6J f 3004.75 644.605 4276.4268 1733.0732
C57BL/6J m 2955.1429 689.1117 4314.6226 1595.6632
CAST/EiJ f 4061.125 644.605 5332.8018 2789.4482
CAST/EiJ m 2767.5 911.6091 4565.9226 969.0774
Crl:CD-1(ICR) f 5791.5 644.605 7063.1768 4519.8232
Crl:CD-1(ICR) m 10717.5 644.605 11989.1768 9445.8232
FVB/NJ f 6051.375 644.605 7323.0518 4779.6982
FVB/NJ m 4168.375 644.605 5440.0518 2896.6982
SJL/J f 3437.625 644.605 4709.3018 2165.9482
SJL/J m 2885.75 644.605 4157.4268 1614.0732
SPRET/EiJ f 6843.6667 744.3257 8312.0726 5375.2608
SPRET/EiJ m 5801.5714 689.1117 7161.0511 4442.0917
Tac:SW f 3952.375 644.605 5224.0518 2680.6982
Tac:SW m 4860.25 644.605 6131.9268 3588.5732


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 7637.25 455.8046 8536.4613 6738.0387
129S6/SvEvTac both 5033.4375 455.8046 5932.6488 4134.2262
129X1/SvJ both 6299.6875 455.8046 7198.8988 5400.4762
A/J both 1762.6786 471.8025 2693.4507 831.9065
BALB/cByJ both 3210.5446 471.8025 4141.3168 2279.7725
BALB/cJ both 4001.75 455.8046 4900.9613 3102.5387
C3H/HeJ both 2490.6875 455.8046 3389.8988 1591.4762
C57BL/6J both 2979.9464 471.8025 3910.7185 2049.1743
CAST/EiJ both 3414.3125 558.2443 4515.6169 2313.0081
Crl:CD-1(ICR) both 8254.5 455.8046 9153.7113 7355.2887
FVB/NJ both 5109.875 455.8046 6009.0863 4210.6637
SJL/J both 3161.6875 455.8046 4060.8988 2262.4762
SPRET/EiJ both 6322.619 507.1725 7323.169 5322.0691
Tac:SW both 4406.3125 455.8046 5305.5238 3507.1012




  GWAS USING LINEAR MIXED MODELS