Project measures / variables set:   Berndt2   airway_elas

ID, description, units MPD:35191   airway_elas   lung tissue dynamic elastance (H20 pressure)   [cm/mL]  
methacholine study
Measures
• saline    • 1 MCh    • 3 MCh    • 10 MCh    • 30 MCh    • response index
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure ventilator
Comparisonrepeated measures, baseline then treated multiple doses, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
Values
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Created with Highcharts 6.0.7Chart context menuFemaleBerndt235191,35192,35193,35194,35195lung tissue dynamic elastance (H20 pressure)saline1 MCh3 MCh10 MCh30 MCh129S1/SvImJA/JAKR/JBALB/cByJBALB/cJBTBR T<+> Itpr3/JBUB/BnJC3H/HeJC57BL/10JC57BL/6JC57BLKS/JC57BR/cdJC57L/JCBA/JCE/JDBA/1JDBA/2JFVB/NJI/LnJKK/HlJLP/JNOD/ShiLtJNON/ShiLtJNZW/LacJPL/JRIIIS/JSJL/JSM/JSWR/J501001500200
Strains
measured value [cm/mL]
Created with Highcharts 6.0.7Chart context menuMaleBerndt235191,35192,35193,35194,35195lung tissue dynamic elastance (H20 pressure)saline1 MCh3 MCh10 MCh30 MCh129S1/SvImJA/JAKR/JBALB/cByJBALB/cJBTBR T<+> Itpr3/JBUB/BnJC3H/HeJC57BL/10JC57BL/6JC57BLKS/JC57BR/cdJC57L/JCBA/JCE/JDBA/1JDBA/2JFVB/NJI/LnJKK/HlJLP/JNOD/ShiLtJNON/ShiLtJNZW/LacJPL/JRIIIS/JSJL/JSM/JSWR/J501001500200
Strains
measured value [cm/mL]


  OVERLAPPING STRAIN CURVES
Data
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Berndt2 - lung tissue dynamic elastance (H20 pressure)


Created with Highcharts 6.0.7measureChart context menuFemale129S1/SvImJA/JAKR/JBALB/cByJBALB/cJBTBR T+ Itpr3tf/JBUB/BnJC3H/HeJC57BL/10JC57BL/6JC57BLKS/JC57BR/cdJC57L/JCBA/JCE/JDBA/1JDBA/2JFVB/NJI/LnJKK/HlJLP/JNOD/ShiLtJNON/ShiLtJNZW/LacJPL/JRIIIS/JSJL/JSM/JSWR/Jsaline1 MCh3 MCh10 MCh30 MCh255075100125150175
cm/mL

Created with Highcharts 6.0.7measureChart context menuMale129S1/SvImJA/JAKR/JBALB/cByJBALB/cJBTBR T+ Itpr3tf/JBUB/BnJC3H/HeJC57BL/10JC57BL/6JC57BLKS/JC57BR/cdJC57L/JCBA/JCE/JDBA/1JDBA/2JFVB/NJI/LnJKK/HlJLP/JNOD/ShiLtJNON/ShiLtJNZW/LacJPL/JRIIIS/JSJL/JSM/JSWR/Jsaline1 MCh3 MCh10 MCh30 MCh0255075100125150
cm/mL


  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   sex 1 33211.6552 33211.6552 70.8765 < 0.0001
between   strain 23 143627.8166 6244.6877 13.3267 < 0.0001
between   sex:strain 23 32354.1322 1406.7014 3.002 < 0.0001
between   Residuals 251 117614.8551 468.5851
within   group 4 269251.8537 67312.9634 648.1558 < 0.0001
within   group:sex 4 238.5683 59.6421 0.5743 0.6813
within   group:strain 92 31342.7553 340.6821 3.2804 < 0.0001
within   group:sex:strain 92 26692.6337 290.1373 2.7937 < 0.0001
within   Residuals 1004 104268.4689 103.8531

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested
SexAge
Berndt2 35191 ventilator methacholine lung tissue dynamic elastance (H20 pressure)   [cm/mL]   saline  airway_elas_saline inbred 29 both 9-12wks
Berndt2 35192 ventilator methacholine lung tissue dynamic elastance (H20 pressure)   [cm/mL]   1 MCh  airway_elas_mch1 inbred 29 both 9-12wks
Berndt2 35193 ventilator methacholine lung tissue dynamic elastance (H20 pressure)   [cm/mL]   3 MCh  airway_elas_mch3 inbred 29 both 9-12wks
Berndt2 35194 ventilator methacholine lung tissue dynamic elastance (H20 pressure)   [cm/mL]   10 MCh  airway_elas_mch10 inbred 29 both 9-12wks
Berndt2 35195 ventilator methacholine lung tissue dynamic elastance (H20 pressure)   [cm/mL]   30 MCh  airway_elas_mch30 inbred 29 both 9-12wks
Berndt2 35196 ventilator methacholine lung tissue dynamic elastance (H20 pressure)   [cm/mL]   response index  airway_elas_slope inbred 29 both 9-12wks (supplemental /
  summary measure)