Project measure / variable:   Berndt2   airway_elas_mch10

ID, description, units MPD:35194   airway_elas_mch10   lung tissue dynamic elastance (H20 pressure)   [cm/mL]  10 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt2 - lung tissue dynamic elastance (H20 pressure) 10 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means72.1   cm/mL 69.9   cm/mL
Median of the strain means69.4   cm/mL 68.9   cm/mL
SD of the strain means± 15.3 ± 17.6
Coefficient of variation (CV)0.212 0.251
Min–max range of strain means49.9   –   110   cm/mL 39.9   –   112   cm/mL
Mean sample size per strain8.5   mice 9.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1390.2238 1390.2238 4.3564 0.0374
strain 28 93480.7043 3338.5966 10.4619 < 0.0001
sex:strain 28 30673.8793 1095.4957 3.4329 < 0.0001
Residuals 460 146794.5748 319.1186


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 49.9 8.93   9 2.98 0.179 39.4, 63.6 -1.45
129S1/SvImJ m 68.9 23.9   8 8.45 0.347 45.0, 106.0 -0.06
A/J f 94.7 27.4   10 8.67 0.29 60.3, 140.0 1.48
A/J m 112.0 19.9   4 9.94 0.177 96.8, 140.0 2.39
AKR/J f 64.4 7.43   9 2.48 0.115 54.2, 76.0 -0.5
AKR/J m 92.4 20.8   6 8.48 0.225 71.8, 131.0 1.28
BALB/cByJ f 66.6 22.4   8 7.93 0.336 45.1, 114.0 -0.36
BALB/cByJ m 58.0 20.9   8 7.38 0.36 34.9, 102.0 -0.68
BALB/cJ f 85.4 23.3   8 8.23 0.273 57.0, 113.0 0.87
BALB/cJ m 53.8 17.5   12 5.06 0.325 29.0, 85.5 -0.92
BTBR T+ Itpr3tf/J f 51.5 9.04   10 2.86 0.175 40.1, 68.3 -1.35
BTBR T+ Itpr3tf/J m 48.2 14.2   10 4.49 0.295 35.9, 74.3 -1.24
BUB/BnJ f 64.9 10.1   9 3.35 0.155 53.0, 80.3 -0.47
BUB/BnJ m 74.6 23.2   10 7.34 0.311 48.7, 113.0 0.27
C3H/HeJ f 56.6 9.32   10 2.95 0.165 47.5, 75.7 -1.01
C3H/HeJ m 45.0 10.5   9 3.49 0.232 33.9, 68.3 -1.42
C57BL/10J f 69.4 13.2   9 4.4 0.19 57.2, 98.8 -0.18
C57BL/10J m 56.5 7.72   10 2.44 0.137 49.6, 71.2 -0.77
C57BL/6J f 58.9 11.5   7 4.34 0.195 48.8, 76.4 -0.86
C57BL/6J m 77.1 22.7   8 8.03 0.295 50.7, 120.0 0.41
C57BLKS/J f 74.9 10.5   9 3.49 0.14 58.3, 89.1 0.18
C57BLKS/J m 71.1 12.7   12 3.65 0.178 49.4, 98.1 0.07
C57BR/cdJ f 101.0 24.3   6 9.92 0.241 84.3, 147.0 1.89
C57BR/cdJ m 59.6 15.2   12 4.4 0.256 39.0, 89.6 -0.59
C57L/J f 64.5 24.2   6 9.86 0.374 41.9, 106.0 -0.5
C57L/J m 63.3 27.8   10 8.79 0.439 39.1, 116.0 -0.38
CBA/J f 75.9 13.6   8 4.82 0.179 62.8, 103.0 0.25
CBA/J m 58.5 7.73   11 2.33 0.132 50.5, 75.3 -0.65
CE/J f 65.9 13.1   9 4.35 0.198 53.4, 97.4 -0.41
CE/J m 44.6 5.52   9 1.84 0.124 39.4, 55.0 -1.44
DBA/1J f 110.0 40.9   9 13.6 0.371 74.2, 198.0 2.48
DBA/1J m 101.0 22.5   9 7.51 0.222 71.0, 140.0 1.77
DBA/2J f 77.8 13.7   10 4.33 0.176 50.4, 97.1 0.37
DBA/2J m 85.8 29.6   10 9.35 0.344 48.4, 147.0 0.9
FVB/NJ f 62.7 10.2   10 3.22 0.163 39.2, 79.6 -0.62
FVB/NJ m 88.5 25.2   10 7.97 0.285 55.6, 137.0 1.06
I/LnJ f 82.4 8.37   6 3.42 0.102 74.3, 96.8 0.68
I/LnJ m 72.4 23.4   8 8.28 0.323 44.0, 116.0 0.14
KK/HlJ f 71.4 18.7   9 6.22 0.261 46.5, 105.0 -0.05
KK/HlJ m 65.5 16.0   10 5.07 0.245 43.9, 101.0 -0.25
LP/J f 58.1 11.1   9 3.71 0.191 48.5, 84.6 -0.92
LP/J m 64.4 17.6   12 5.09 0.274 46.3, 111.0 -0.32
NOD/ShiLtJ f 77.7 22.2   9 7.39 0.286 56.6, 130.0 0.37
NOD/ShiLtJ m 67.2 11.2   11 3.37 0.166 48.1, 87.4 -0.16
NON/ShiLtJ f 55.1 9.63   7 3.64 0.175 42.4, 68.0 -1.11
NON/ShiLtJ m 54.9 11.5   7 4.35 0.21 39.3, 73.1 -0.86
NZW/LacJ f 49.9 10.4   8 3.67 0.208 38.5, 67.4 -1.45
NZW/LacJ m 39.9 10.0   10 3.17 0.252 30.5, 64.1 -1.71
PL/J f 89.6 16.3   9 5.43 0.182 65.8, 122.0 1.15
PL/J m 79.8 15.5   8 5.48 0.194 57.5, 102.0 0.56
RIIIS/J f 88.0 15.3   5 6.85 0.174 71.5, 110.0 1.04
RIIIS/J m 76.9 25.0   9 8.32 0.325 54.2, 135.0 0.4
SJL/J f 75.3 11.6   8 4.11 0.154 60.0, 95.5 0.21
SJL/J m 86.3 16.2   10 5.11 0.187 65.3, 119.0 0.93
SM/J f 82.8 18.3   10 5.79 0.221 59.3, 125.0 0.7
SM/J m 92.7 14.7   8 5.2 0.159 81.2, 127.0 1.3
SWR/J f 65.3 13.5   9 4.51 0.207 46.0, 87.6 -0.44
SWR/J m 69.4 22.5   12 6.49 0.324 49.3, 129.0 -0.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 49.9333 5.9546 61.635 38.2317
129S1/SvImJ m 68.8625 6.3158 81.274 56.451
A/J f 94.69 5.6491 105.7912 83.5888
A/J m 112.475 8.9319 130.0275 94.9225
AKR/J f 64.3556 5.9546 76.0572 52.6539
AKR/J m 92.3667 7.2929 106.6982 78.0351
BALB/cByJ f 66.65 6.3158 79.0615 54.2385
BALB/cByJ m 58.0375 6.3158 70.449 45.626
BALB/cJ f 85.4 6.3158 97.8115 72.9885
BALB/cJ m 53.825 5.1569 63.9589 43.6911
BTBR T+ Itpr3tf/J f 51.55 5.6491 62.6512 40.4488
BTBR T+ Itpr3tf/J m 48.16 5.6491 59.2612 37.0588
BUB/BnJ f 64.9 5.9546 76.6016 53.1984
BUB/BnJ m 74.63 5.6491 85.7312 63.5288
C3H/HeJ f 56.62 5.6491 67.7212 45.5188
C3H/HeJ m 45.0444 5.9546 56.7461 33.3428
C57BL/10J f 69.4111 5.9546 81.1128 57.7095
C57BL/10J m 56.51 5.6491 67.6112 45.4088
C57BL/6J f 58.9143 6.7519 72.1827 45.6459
C57BL/6J m 77.0875 6.3158 89.499 64.676
C57BLKS/J f 74.9222 5.9546 86.6239 63.2206
C57BLKS/J m 71.1 5.1569 81.2339 60.9661
C57BR/cdJ f 100.7 7.2929 115.0315 86.3685
C57BR/cdJ m 59.5583 5.1569 69.6923 49.4244
C57L/J f 64.55 7.2929 78.8815 50.2185
C57L/J m 63.29 5.6491 74.3912 52.1888
CBA/J f 75.9 6.3158 88.3115 63.4885
CBA/J m 58.5273 5.3862 69.1118 47.9427
CE/J f 65.9222 5.9546 77.6239 54.2206
CE/J m 44.6333 5.9546 56.335 32.9317
DBA/1J f 110.2333 5.9546 121.935 98.5317
DBA/1J m 101.2333 5.9546 112.935 89.5317
DBA/2J f 77.76 5.6491 88.8612 66.6588
DBA/2J m 85.79 5.6491 96.8912 74.6888
FVB/NJ f 62.66 5.6491 73.7612 51.5588
FVB/NJ m 88.54 5.6491 99.6412 77.4388
I/LnJ f 82.35 7.2929 96.6815 68.0185
I/LnJ m 72.3875 6.3158 84.799 59.976
KK/HlJ f 71.4222 5.9546 83.1239 59.7206
KK/HlJ m 65.47 5.6491 76.5712 54.3688
LP/J f 58.1444 5.9546 69.8461 46.4428
LP/J m 64.3833 5.1569 74.5173 54.2494
NOD/ShiLtJ f 77.6667 5.9546 89.3683 65.965
NOD/ShiLtJ m 67.2091 5.3862 77.7936 56.6246
NON/ShiLtJ f 55.0571 6.7519 68.3256 41.7887
NON/ShiLtJ m 54.9143 6.7519 68.1827 41.6459
NZW/LacJ f 49.95 6.3158 62.3615 37.5385
NZW/LacJ m 39.86 5.6491 50.9612 28.7588
PL/J f 89.6222 5.9546 101.3239 77.9206
PL/J m 79.775 6.3158 92.1865 67.3635
RIIIS/J f 88.04 7.989 103.7394 72.3406
RIIIS/J m 76.9444 5.9546 88.6461 65.2428
SJL/J f 75.35 6.3158 87.7615 62.9385
SJL/J m 86.31 5.6491 97.4112 75.2088
SM/J f 82.75 5.6491 93.8512 71.6488
SM/J m 92.6875 6.3158 105.099 80.276
SWR/J f 65.3 5.9546 77.0016 53.5984
SWR/J m 69.4333 5.1569 79.5673 59.2994


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 59.3979 4.3401 67.9269 50.8689
A/J both 103.5825 5.2842 113.9667 93.1983
AKR/J both 78.3611 4.7075 87.6121 69.1101
BALB/cByJ both 62.3438 4.466 71.12 53.5675
BALB/cJ both 69.6125 4.0769 77.6241 61.6009
BTBR T+ Itpr3tf/J both 49.855 3.9945 57.7047 42.0053
BUB/BnJ both 69.765 4.1039 77.8298 61.7002
C3H/HeJ both 50.8322 4.1039 58.897 42.7674
C57BL/10J both 62.9606 4.1039 71.0254 54.8957
C57BL/6J both 68.0009 4.6227 77.0852 58.9166
C57BLKS/J both 73.0111 3.9386 80.751 65.2712
C57BR/cdJ both 80.1292 4.466 88.9054 71.3529
C57L/J both 63.92 4.6124 72.9841 54.8559
CBA/J both 67.2136 4.1503 75.3696 59.0577
CE/J both 55.2778 4.2106 63.5521 47.0035
DBA/1J both 105.7333 4.2106 114.0076 97.459
DBA/2J both 81.775 3.9945 89.6247 73.9253
FVB/NJ both 75.6 3.9945 83.4497 67.7503
I/LnJ both 77.3687 4.8238 86.8482 67.8893
KK/HlJ both 68.4461 4.1039 76.5109 60.3813
LP/J both 61.2639 3.9386 69.0038 53.524
NOD/ShiLtJ both 72.4379 4.0146 80.3271 64.5486
NON/ShiLtJ both 54.9857 4.7743 64.3679 45.6035
NZW/LacJ both 44.905 4.2368 53.2309 36.5791
PL/J both 84.6986 4.3401 93.2276 76.1696
RIIIS/J both 82.4922 4.982 92.2825 72.7019
SJL/J both 80.83 4.2368 89.1559 72.5041
SM/J both 87.7188 4.2368 96.0446 79.3929
SWR/J both 67.3667 3.9386 75.1066 59.6268




  GWAS USING LINEAR MIXED MODELS