Project measure / variable:   Berndt2   airway_elas_saline

ID, description, units MPD:35191   airway_elas_saline   lung tissue dynamic elastance (H20 pressure)   [cm/mL]  saline  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt2 - lung tissue dynamic elastance (H20 pressure) saline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means49.6   cm/mL 43.0   cm/mL
Median of the strain means48.7   cm/mL 42.3   cm/mL
SD of the strain means± 8.85 ± 8.91
Coefficient of variation (CV)0.178 0.207
Min–max range of strain means37.1   –   66.1   cm/mL 28.6   –   66.6   cm/mL
Mean sample size per strain8.7   mice 10.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5716.9491 5716.9491 122.6399 < 0.0001
strain 28 34047.1437 1215.9694 26.0849 < 0.0001
sex:strain 28 5785.1408 206.6122 4.4322 < 0.0001
Residuals 479 22328.9441 46.6157


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 42.5 5.39   9 1.8 0.127 35.3, 53.3 -0.8
129S1/SvImJ m 45.6 7.26   8 2.57 0.159 38.2, 60.0 0.29
A/J f 48.0 16.4   10 5.18 0.342 36.8, 92.5 -0.18
A/J m 35.1 3.3   9 1.1 0.0941 30.3, 40.0 -0.88
AKR/J f 48.7 8.5   9 2.83 0.175 39.9, 66.6 -0.1
AKR/J m 50.4 8.75   10 2.77 0.174 39.5, 63.6 0.83
BALB/cByJ f 38.6 4.02   8 1.42 0.104 31.9, 42.9 -1.24
BALB/cByJ m 37.6 6.69   10 2.12 0.178 26.9, 47.1 -0.6
BALB/cJ f 46.8 5.19   8 1.83 0.111 39.6, 55.9 -0.32
BALB/cJ m 30.3 3.47   12 1.0 0.114 25.4, 35.8 -1.42
BTBR T+ Itpr3tf/J f 37.1 7.33   10 2.32 0.197 25.9, 51.2 -1.41
BTBR T+ Itpr3tf/J m 29.4 3.16   10 1.0 0.108 26.1, 36.9 -1.52
BUB/BnJ f 39.8 5.23   9 1.74 0.131 33.2, 49.6 -1.11
BUB/BnJ m 38.3 2.73   10 0.864 0.0713 33.4, 42.2 -0.52
C3H/HeJ f 37.1 3.16   10 0.999 0.0851 33.2, 44.8 -1.41
C3H/HeJ m 32.2 4.43   9 1.48 0.137 24.7, 39.5 -1.21
C57BL/10J f 57.8 5.98   9 1.99 0.103 47.4, 69.3 0.93
C57BL/10J m 42.3 7.54   10 2.38 0.178 36.2, 60.0 -0.08
C57BL/6J f 48.7 3.03   7 1.14 0.0621 45.5, 53.7 -0.1
C57BL/6J m 41.7 4.56   8 1.61 0.109 35.8, 48.2 -0.14
C57BLKS/J f 55.1 7.72   9 2.57 0.14 47.4, 67.9 0.62
C57BLKS/J m 47.6 8.15   12 2.35 0.171 35.3, 56.8 0.52
C57BR/cdJ f 62.6 16.6   7 6.28 0.266 50.6, 96.0 1.47
C57BR/cdJ m 42.3 5.38   12 1.55 0.127 33.3, 51.4 -0.08
C57L/J f 45.4 5.68   6 2.32 0.125 38.9, 54.3 -0.47
C57L/J m 42.6 9.33   10 2.95 0.219 32.8, 64.2 -0.04
CBA/J f 48.2 3.89   8 1.38 0.0807 43.7, 54.8 -0.16
CBA/J m 44.6 5.94   11 1.79 0.133 37.3, 53.5 0.18
CE/J f 41.4 5.0   9 1.67 0.121 33.6, 50.6 -0.93
CE/J m 33.4 3.62   9 1.21 0.108 28.4, 39.5 -1.07
DBA/1J f 56.6 6.62   9 2.21 0.117 44.4, 63.9 0.79
DBA/1J m 60.6 8.24   11 2.48 0.136 50.8, 73.8 1.98
DBA/2J f 53.1 6.81   10 2.15 0.128 44.4, 66.5 0.4
DBA/2J m 42.2 3.82   10 1.21 0.0906 38.0, 50.5 -0.09
FVB/NJ f 48.7 6.21   10 1.96 0.127 42.5, 56.7 -0.1
FVB/NJ m 45.2 5.4   10 1.71 0.12 36.9, 51.9 0.25
I/LnJ f 49.2 6.51   9 2.17 0.132 41.7, 59.1 -0.04
I/LnJ m 46.7 7.53   8 2.66 0.161 38.4, 60.9 0.42
KK/HlJ f 39.4 2.71   9 0.905 0.0689 34.6, 43.6 -1.15
KK/HlJ m 41.6 2.51   10 0.794 0.0603 37.9, 46.6 -0.15
LP/J f 52.8 8.68   9 2.89 0.164 45.3, 72.5 0.36
LP/J m 42.4 3.45   12 0.996 0.0814 37.0, 48.2 -0.06
NOD/ShiLtJ f 57.4 7.15   9 2.38 0.124 48.2, 70.4 0.88
NOD/ShiLtJ m 41.3 5.01   11 1.51 0.121 35.1, 49.1 -0.19
NON/ShiLtJ f 40.4 5.89   7 2.22 0.146 32.4, 48.0 -1.04
NON/ShiLtJ m 35.0 2.59   7 0.981 0.0741 30.4, 38.6 -0.9
NZW/LacJ f 37.4 2.33   8 0.822 0.0623 33.4, 40.3 -1.38
NZW/LacJ m 28.6 2.02   10 0.639 0.0708 25.1, 31.2 -1.61
PL/J f 65.0 7.68   9 2.56 0.118 53.3, 76.5 1.74
PL/J m 51.3 6.46   8 2.28 0.126 41.9, 63.5 0.93
RIIIS/J f 59.5 13.6   5 6.06 0.228 51.9, 83.6 1.12
RIIIS/J m 56.1 11.2   9 3.72 0.199 46.4, 84.1 1.47
SJL/J f 66.1 9.41   8 3.33 0.142 54.6, 78.5 1.87
SJL/J m 50.9 7.6   12 2.2 0.149 43.4, 68.5 0.89
SM/J f 62.3 5.62   10 1.78 0.0901 52.8, 67.9 1.44
SM/J m 66.6 6.38   8 2.26 0.0958 59.8, 77.6 2.65
SWR/J f 52.4 8.54   9 2.85 0.163 43.5, 70.8 0.32
SWR/J m 44.5 6.48   12 1.87 0.146 36.8, 59.5 0.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 42.5 2.2759 46.9719 38.0281
129S1/SvImJ m 45.6 2.4139 50.3432 40.8568
A/J f 47.97 2.1591 52.2124 43.7276
A/J m 35.1333 2.2759 39.6052 30.6614
AKR/J f 48.7111 2.2759 53.183 44.2392
AKR/J m 50.39 2.1591 54.6324 46.1476
BALB/cByJ f 38.625 2.4139 43.3682 33.8818
BALB/cByJ m 37.57 2.1591 41.8124 33.3276
BALB/cJ f 46.775 2.4139 51.5182 42.0318
BALB/cJ m 30.325 1.971 34.1978 26.4522
BTBR T+ Itpr3tf/J f 37.14 2.1591 41.3824 32.8976
BTBR T+ Itpr3tf/J m 29.42 2.1591 33.6624 25.1776
BUB/BnJ f 39.7889 2.2759 44.2608 35.317
BUB/BnJ m 38.34 2.1591 42.5824 34.0976
C3H/HeJ f 37.15 2.1591 41.3924 32.9076
C3H/HeJ m 32.2444 2.2759 36.7163 27.7725
C57BL/10J f 57.8 2.2759 62.2719 53.3281
C57BL/10J m 42.31 2.1591 46.5524 38.0676
C57BL/6J f 48.7143 2.5806 53.7849 43.6436
C57BL/6J m 41.675 2.4139 46.4182 36.9318
C57BLKS/J f 55.1222 2.2759 59.5941 50.6503
C57BLKS/J m 47.6 1.971 51.4728 43.7272
C57BR/cdJ f 62.6 2.5806 67.6707 57.5293
C57BR/cdJ m 42.3167 1.971 46.1894 38.4439
C57L/J f 45.3667 2.7873 50.8436 39.8897
C57L/J m 42.56 2.1591 46.8024 38.3176
CBA/J f 48.225 2.4139 52.9682 43.4818
CBA/J m 44.6273 2.0586 48.6723 40.5823
CE/J f 41.4222 2.2759 45.8941 36.9503
CE/J m 33.3889 2.2759 37.8608 28.917
DBA/1J f 56.5556 2.2759 61.0275 52.0837
DBA/1J m 60.6 2.0586 64.645 56.555
DBA/2J f 53.07 2.1591 57.3124 48.8276
DBA/2J m 42.17 2.1591 46.4124 37.9276
FVB/NJ f 48.75 2.1591 52.9924 44.5076
FVB/NJ m 45.17 2.1591 49.4124 40.9276
I/LnJ f 49.2444 2.2759 53.7163 44.7725
I/LnJ m 46.7125 2.4139 51.4557 41.9693
KK/HlJ f 39.4 2.2759 43.8719 34.9281
KK/HlJ m 41.63 2.1591 45.8724 37.3876
LP/J f 52.8111 2.2759 57.283 48.3392
LP/J m 42.375 1.971 46.2478 38.5022
NOD/ShiLtJ f 57.4333 2.2759 61.9052 52.9614
NOD/ShiLtJ m 41.3182 2.0586 45.3632 37.2732
NON/ShiLtJ f 40.4429 2.5806 45.5135 35.3722
NON/ShiLtJ m 35.0143 2.5806 40.0849 29.9436
NZW/LacJ f 37.35 2.4139 42.0932 32.6068
NZW/LacJ m 28.55 2.1591 32.7924 24.3076
PL/J f 65.0333 2.2759 69.5052 60.5614
PL/J m 51.3375 2.4139 56.0807 46.5943
RIIIS/J f 59.48 3.0534 65.4797 53.4803
RIIIS/J m 56.0778 2.2759 60.5497 51.6059
SJL/J f 66.1 2.4139 70.8432 61.3568
SJL/J m 50.95 1.971 54.8228 47.0772
SM/J f 62.34 2.1591 66.5824 58.0976
SM/J m 66.6125 2.4139 71.3557 61.8693
SWR/J f 52.4333 2.2759 56.9052 47.9614
SWR/J m 44.475 1.971 48.3478 40.6022


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 44.05 1.6588 47.3094 40.7906
A/J both 41.5517 1.5685 44.6337 38.4696
AKR/J both 49.5506 1.5685 52.6326 46.4685
BALB/cByJ both 38.0975 1.6193 41.2793 34.9157
BALB/cJ both 38.55 1.5582 41.6117 35.4883
BTBR T+ Itpr3tf/J both 33.28 1.5267 36.2798 30.2802
BUB/BnJ both 39.0644 1.5685 42.1465 35.9824
C3H/HeJ both 34.6972 1.5685 37.7793 31.6152
C57BL/10J both 50.055 1.5685 53.137 46.973
C57BL/6J both 45.1946 1.7668 48.6663 41.723
C57BLKS/J both 51.3611 1.5053 54.319 48.4032
C57BR/cdJ both 52.4583 1.6236 55.6486 49.2681
C57L/J both 43.9633 1.7629 47.4273 40.4994
CBA/J both 46.4261 1.5863 49.543 43.3093
CE/J both 37.4056 1.6093 40.5677 34.2434
DBA/1J both 58.5778 1.5344 61.5927 55.5628
DBA/2J both 47.62 1.5267 50.6198 44.6202
FVB/NJ both 46.96 1.5267 49.9598 43.9602
I/LnJ both 47.9785 1.6588 51.2379 44.719
KK/HlJ both 40.515 1.5685 43.597 37.433
LP/J both 47.5931 1.5053 50.5509 44.6352
NOD/ShiLtJ both 49.3758 1.5344 52.3907 46.3608
NON/ShiLtJ both 37.7286 1.8247 41.3141 34.1431
NZW/LacJ both 32.95 1.6193 36.1318 29.7682
PL/J both 58.1854 1.6588 61.4448 54.926
RIIIS/J both 57.7789 1.9041 61.5203 54.0374
SJL/J both 58.525 1.5582 61.5867 55.4633
SM/J both 64.4763 1.6193 67.6581 61.2944
SWR/J both 48.4542 1.5053 51.412 45.4963




  GWAS USING LINEAR MIXED MODELS