Project measure / variable:   Berndt2   airway_elas_mch3

ID, description, units MPD:35193   airway_elas_mch3   lung tissue dynamic elastance (H20 pressure)   [cm/mL]  3 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt2 - lung tissue dynamic elastance (H20 pressure) 3 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means61.0   cm/mL 55.1   cm/mL
Median of the strain means59.6   cm/mL 51.7   cm/mL
SD of the strain means± 11.0 ± 13.2
Coefficient of variation (CV)0.181 0.239
Min–max range of strain means42.3   –   82.7   cm/mL 34.8   –   83.3   cm/mL
Mean sample size per strain8.7   mice 9.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4708.0158 4708.0158 32.1198 < 0.0001
strain 28 63314.3792 2261.2278 15.4269 < 0.0001
sex:strain 28 13114.9204 468.39 3.1955 < 0.0001
Residuals 477 69917.0627 146.5767


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 46.9 6.77   9 2.26 0.144 40.2, 56.6 -1.28
129S1/SvImJ m 53.7 12.5   8 4.41 0.232 40.9, 77.6 -0.11
A/J f 63.1 17.7   10 5.58 0.28 44.8, 97.5 0.19
A/J m 76.5 19.4   9 6.45 0.253 48.5, 114.0 1.63
AKR/J f 55.4 8.03   9 2.68 0.145 46.0, 69.4 -0.51
AKR/J m 71.8 17.3   10 5.48 0.242 56.5, 103.0 1.27
BALB/cByJ f 52.9 13.7   8 4.84 0.259 39.0, 78.2 -0.74
BALB/cByJ m 44.6 9.61   8 3.4 0.215 30.2, 56.4 -0.8
BALB/cJ f 65.0 17.8   8 6.28 0.273 41.3, 90.0 0.36
BALB/cJ m 40.1 7.39   12 2.13 0.184 31.4, 57.7 -1.14
BTBR T+ Itpr3tf/J f 45.4 5.29   10 1.67 0.116 35.8, 55.5 -1.42
BTBR T+ Itpr3tf/J m 38.2 4.25   10 1.34 0.111 31.4, 46.8 -1.28
BUB/BnJ f 53.1 5.37   9 1.79 0.101 47.1, 59.8 -0.72
BUB/BnJ m 47.0 5.97   10 1.89 0.127 35.9, 56.2 -0.62
C3H/HeJ f 46.8 4.1   10 1.3 0.0877 39.0, 52.9 -1.29
C3H/HeJ m 38.4 5.33   9 1.78 0.139 32.2, 48.0 -1.27
C57BL/10J f 61.5 8.5   9 2.83 0.138 50.9, 81.5 0.04
C57BL/10J m 49.5 7.79   10 2.46 0.157 37.6, 67.3 -0.43
C57BL/6J f 57.3 9.74   7 3.68 0.17 48.3, 76.4 -0.34
C57BL/6J m 62.0 12.1   8 4.28 0.195 45.5, 80.8 0.52
C57BLKS/J f 65.5 9.5   9 3.17 0.145 49.3, 78.8 0.4
C57BLKS/J m 58.5 8.82   12 2.55 0.151 42.2, 70.9 0.26
C57BR/cdJ f 71.5 15.4   7 5.81 0.215 53.3, 101.0 0.95
C57BR/cdJ m 51.1 8.76   12 2.53 0.171 36.1, 63.8 -0.3
C57L/J f 52.5 11.4   6 4.64 0.216 37.3, 71.6 -0.77
C57L/J m 50.0 17.5   10 5.54 0.35 36.5, 87.2 -0.39
CBA/J f 66.0 9.23   8 3.26 0.14 57.8, 85.1 0.45
CBA/J m 51.7 5.49   11 1.65 0.106 43.5, 62.0 -0.26
CE/J f 52.9 5.63   9 1.88 0.106 44.8, 63.3 -0.74
CE/J m 39.6 3.97   9 1.32 0.1 31.2, 45.8 -1.18
DBA/1J f 77.4 13.2   9 4.4 0.17 62.6, 107.0 1.48
DBA/1J m 82.2 15.4   11 4.64 0.187 60.8, 110.0 2.06
DBA/2J f 67.0 13.9   10 4.39 0.207 49.3, 93.6 0.54
DBA/2J m 56.1 9.16   10 2.9 0.163 43.3, 69.3 0.08
FVB/NJ f 56.9 8.34   10 2.64 0.146 44.5, 66.1 -0.38
FVB/NJ m 61.2 16.1   10 5.08 0.262 43.0, 96.0 0.46
I/LnJ f 80.7 42.7   9 14.2 0.53 49.3, 178.0 1.78
I/LnJ m 57.5 15.5   8 5.47 0.269 41.3, 89.9 0.18
KK/HlJ f 53.5 7.2   9 2.4 0.135 41.9, 62.7 -0.68
KK/HlJ m 49.6 8.05   10 2.55 0.162 39.6, 66.5 -0.42
LP/J f 56.4 9.4   9 3.13 0.167 47.9, 78.0 -0.42
LP/J m 48.3 5.33   12 1.54 0.11 42.6, 62.0 -0.52
NOD/ShiLtJ f 64.4 12.0   9 4.01 0.187 49.6, 82.5 0.3
NOD/ShiLtJ m 51.6 9.74   11 2.94 0.189 41.7, 71.6 -0.27
NON/ShiLtJ f 50.5 4.87   7 1.84 0.0965 45.5, 58.8 -0.96
NON/ShiLtJ m 42.1 5.59   7 2.11 0.133 34.3, 49.9 -0.99
NZW/LacJ f 42.3 2.8   8 0.991 0.0663 36.3, 45.5 -1.7
NZW/LacJ m 34.8 5.3   10 1.68 0.153 25.3, 41.2 -1.54
PL/J f 82.7 13.8   9 4.59 0.167 66.3, 111.0 1.96
PL/J m 63.2 12.9   8 4.55 0.204 53.6, 92.5 0.62
RIIIS/J f 72.4 8.11   5 3.63 0.112 63.1, 84.0 1.03
RIIIS/J m 67.3 16.1   9 5.37 0.239 51.0, 94.2 0.93
SJL/J f 74.0 6.94   8 2.45 0.0938 62.6, 82.7 1.17
SJL/J m 72.4 12.1   12 3.5 0.167 51.4, 92.4 1.32
SM/J f 76.8 11.3   10 3.58 0.147 63.6, 90.7 1.43
SM/J m 83.3 14.6   8 5.17 0.176 64.0, 112.0 2.14
SWR/J f 59.6 10.6   9 3.53 0.178 45.7, 79.5 -0.13
SWR/J m 55.6 11.0   12 3.17 0.197 43.8, 76.2 0.04


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 46.9 4.0356 54.8298 38.9702
129S1/SvImJ m 53.7 4.2804 62.1108 45.2892
A/J f 63.1 3.8285 70.6229 55.5771
A/J m 76.5444 4.0356 84.4743 68.6146
AKR/J f 55.4 4.0356 63.3298 47.4702
AKR/J m 71.75 3.8285 79.2729 64.2271
BALB/cByJ f 52.925 4.2804 61.3358 44.5142
BALB/cByJ m 44.625 4.2804 53.0358 36.2142
BALB/cJ f 64.975 4.2804 73.3858 56.5642
BALB/cJ m 40.0917 3.495 46.9591 33.2243
BTBR T+ Itpr3tf/J f 45.41 3.8285 52.9329 37.8871
BTBR T+ Itpr3tf/J m 38.17 3.8285 45.6929 30.6471
BUB/BnJ f 53.1111 4.0356 61.0409 45.1813
BUB/BnJ m 46.99 3.8285 54.5129 39.4671
C3H/HeJ f 46.82 3.8285 54.3429 39.2971
C3H/HeJ m 38.3667 4.0356 46.2965 30.4369
C57BL/10J f 61.4778 4.0356 69.4076 53.548
C57BL/10J m 49.51 3.8285 57.0329 41.9871
C57BL/6J f 57.3 4.576 66.2916 48.3084
C57BL/6J m 62.0375 4.2804 70.4483 53.6267
C57BLKS/J f 65.5222 4.0356 73.452 57.5924
C57BLKS/J m 58.4917 3.495 65.3591 51.6243
C57BR/cdJ f 71.4857 4.576 80.4773 62.4942
C57BR/cdJ m 51.1333 3.495 58.0007 44.2659
C57L/J f 52.5 4.9426 62.212 42.788
C57L/J m 49.99 3.8285 57.5129 42.4671
CBA/J f 66.05 4.2804 74.4608 57.6392
CBA/J m 51.7 3.6504 58.8728 44.5272
CE/J f 52.8667 4.0356 60.7965 44.9369
CE/J m 39.6 4.0356 47.5298 31.6702
DBA/1J f 77.4444 4.0356 85.3743 69.5146
DBA/1J m 82.2455 3.6504 89.4182 75.0727
DBA/2J f 67.05 3.8285 74.5729 59.5271
DBA/2J m 56.06 3.8285 63.5829 48.5371
FVB/NJ f 56.91 3.8285 64.4329 49.3871
FVB/NJ m 61.19 3.8285 68.7129 53.6671
I/LnJ f 80.6556 4.0356 88.5854 72.7257
I/LnJ m 57.5125 4.2804 65.9233 49.1017
KK/HlJ f 53.5444 4.0356 61.4743 45.6146
KK/HlJ m 49.61 3.8285 57.1329 42.0871
LP/J f 56.3889 4.0356 64.3187 48.4591
LP/J m 48.3 3.495 55.1674 41.4326
NOD/ShiLtJ f 64.4444 4.0356 72.3743 56.5146
NOD/ShiLtJ m 51.6 3.6504 58.7728 44.4272
NON/ShiLtJ f 50.5 4.576 59.4916 41.5084
NON/ShiLtJ m 42.1143 4.576 51.1058 33.1227
NZW/LacJ f 42.25 4.2804 50.6608 33.8392
NZW/LacJ m 34.75 3.8285 42.2729 27.2271
PL/J f 82.7111 4.0356 90.6409 74.7813
PL/J m 63.175 4.2804 71.5858 54.7642
RIIIS/J f 72.4 5.4144 83.039 61.761
RIIIS/J m 67.3 4.0356 75.2298 59.3702
SJL/J f 73.9625 4.2804 82.3733 65.5517
SJL/J m 72.4 3.495 79.2674 65.5326
SM/J f 76.79 3.8285 84.3129 69.2671
SM/J m 83.3375 4.2804 91.7483 74.9267
SWR/J f 59.5556 4.0356 67.4854 51.6257
SWR/J m 55.6083 3.495 62.4757 48.7409


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 50.3 2.9414 56.0798 44.5202
A/J both 69.8222 2.7814 75.2875 64.357
AKR/J both 63.575 2.7814 69.0402 58.1098
BALB/cByJ both 48.775 3.0267 54.7224 42.8276
BALB/cJ both 52.5333 2.763 57.9625 47.1042
BTBR T+ Itpr3tf/J both 41.79 2.7072 47.1095 36.4705
BUB/BnJ both 50.0506 2.7814 55.5158 44.5853
C3H/HeJ both 42.5933 2.7814 48.0586 37.1281
C57BL/10J both 55.4939 2.7814 60.9591 50.0286
C57BL/6J both 59.6688 3.133 65.8248 53.5127
C57BLKS/J both 62.0069 2.6693 67.252 56.7619
C57BR/cdJ both 61.3095 2.879 66.9666 55.6525
C57L/J both 51.245 3.126 57.3874 45.1026
CBA/J both 58.875 2.8128 64.402 53.348
CE/J both 46.2333 2.8536 51.8406 40.6261
DBA/1J both 79.8449 2.7208 85.1912 74.4987
DBA/2J both 61.555 2.7072 66.8745 56.2355
FVB/NJ both 59.05 2.7072 64.3695 53.7305
I/LnJ both 69.084 2.9414 74.8638 63.3042
KK/HlJ both 51.5772 2.7814 57.0425 46.112
LP/J both 52.3444 2.6693 57.5895 47.0994
NOD/ShiLtJ both 58.0222 2.7208 63.3685 52.6759
NON/ShiLtJ both 46.3071 3.2357 52.6651 39.9492
NZW/LacJ both 38.5 2.8714 44.1422 32.8578
PL/J both 72.9431 2.9414 78.7228 67.1633
RIIIS/J both 69.85 3.3764 76.4846 63.2154
SJL/J both 73.1813 2.763 78.6104 67.7521
SM/J both 80.0638 2.8714 85.7059 74.4216
SWR/J both 57.5819 2.6693 62.827 52.3369




  GWAS USING LINEAR MIXED MODELS