MPD: Data set: Tordoff3

References (chronological)

1. Tordoff MG, Bachmanov AA, Reed DR. Forty mouse strain survey of water and sodium intake. Physiol Behav. 2007 Aug 15;91(5):620-31. Epub 2007 Apr 1. PubMed 17490693

2. Tordoff MG, Bachmanov AA, Reed DR. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav. 2007 Aug 15;91(5):632-43. Epub 2007 Apr 1. PubMed 17493644

3. Reed DR, Bachmanov AA, Tordoff MG. Forty mouse strain survey of body composition. Physiol Behav. 2007 Aug 15;91(5):593-600. Epub 2007 Apr 1. PubMed 17493645

Tordoff3 downloads
• Download Tordoff3 project data set animal data, as uploaded
• Download Tordoff3 animal data matrix with factor-related expansion applied as necessary
• Download Tordoff3 strain means, SD, N, etc. one row per strain/sex/measure
• Tordoff3 supplementary data

Ontology terms mapped to Tordoff3 measures:

MA:0000009 adipose tissue
MA:0000059 blood
MA:0001459 bone
MA:0001591 taste bud
MA:0002501 plasma
MP:0001259 abnormal body weight
MP:0001562 abnormal circulating calcium level
MP:0002089 abnormal postnatal growth/weight/body size
MP:0003027 abnormal blood pH regulation
MP:0003959 abnormal lean body mass
MP:0004212 abnormal salty taste sensitivity
MP:0005452 abnormal adipose tissue amount
MP:0005457 abnormal percent body fat/body weight
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
VT:0001259 body mass
VT:0001422 drinking behavior trait
VT:0001562 blood calcium amount
VT:0003027 blood acidity-alkalinity balance trait
VT:0004212 salty taste sensitivity trait
VT:0005007 bone mineral mass
VT:0005452 adipose amount
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	Michael G Tordoff Monell Chemical Senses Center, Philadelphia, PA Alexander A Bachmanov Monell Chemical Senses Center, Philadelphia, PA
Contact	Michael G Tordoff tordoff@monell.org Lab web site
Affiliated Center	Monell Chemical Senses Center
Acknowledgements	Funding provided by NIH DK46791 and AA12715 Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program. Funding for the PIXImus II densitometer was provided by Commonwealth of Pennsylvania Health Research Formula Grant #ME-02-169. Technical help provided by Pilchak D, Williams J, Rudolph K, St. Germain N, Belton D, Doman S, Duble T, and Byerly E.
Project type	Phenotype strain survey data set
MPD identifiers	Tordoff3 MPD:103
Data changelog	3 updates/corrections. Initial release date: 11/2002.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Animals were evaluated using Ciba-Corning calcium analyzer and PIXImus II mouse densitometer (DXA).

Procedures conducted:

• body weight
• bottle choice test		Various salt solutions (several concentrations) vs. water.
• DXA		Body mass, fat mass, lean mass, bone mineral density and content.
• metabolic panel		Ionized and total blood calcium, blood pH.
• monitoring system		Bleeding time to collect approx 30 µL.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Tordoff3:4	Tordoff3	colony observation	(none)	age at the start of the 1st test (water) (local parameter) [d] age 10304	inbred w/CC7	40	both		N=10

Tordoff3:5	Tordoff3	body weight	(none)	body weight [g] bw 10305 start end fold change	inbred w/CC7	40	both	8-10wks	N=10

Tordoff3:8	Tordoff3	bottle choice test	(none)	preference for CaCl2 (calcium chloride) solutions [%] CaCl2_pref 10308 concentration (mM): 7.5 25 75	inbred w/CC7	40	both	9-11wks	N=10

Tordoff3:11	Tordoff3	bottle choice test	(none)	preference for CaLa (calcium lactate) solutions [%] CaLa_pref 10311 concentration (mM): 7.5 25 75	inbred w/CC7	40	both	10-12wks	N=10

Tordoff3:14	Tordoff3	bottle choice test	(none)	preference for NaCl (sodium chloride) solutions [%] NaCl_pref 10314 concentration (mM): 25 75 225	inbred w/CC7	40	both	11-13wks	N=10

Tordoff3:17	Tordoff3	bottle choice test	(none)	preference for NaLa (sodium lactate) solutions [%] NaLa_pref 10317 concentration (mM): 25 75 225	inbred w/CC7	40	both	12-14wks	N=10

Tordoff3:20	Tordoff3	monitoring system	(none)	time from tail cut to 1/2 tube of blood collected (approx 30 µL) (local parameter) [s] bleeding_time 10320	inbred w/CC7	40	both	13-15wks	N=10

Tordoff3:21	Tordoff3	metabolic panel	(none)	blood ionized calcium [mg/dL] ionized_Ca 10321	inbred w/CC7	40	both	13-15wks	N=10

Tordoff3:22	Tordoff3	metabolic panel	(none)	blood pH [pH] pH 10322	inbred w/CC7	40	both	13-15wks	N=10

Tordoff3:23	Tordoff3	metabolic panel	(none)	blood ionized calcium adjusted to pH 7.4 [mg/dL] adj_ionized_Ca 10323	inbred w/CC7	40	both	13-15wks	N=10

Tordoff3:24	Tordoff3	metabolic panel	(none)	plasma total calcium [mg/dL] total_calcium 10324	inbred w/CC7	40	both	13-15wks	N=10

Tordoff3:25	Tordoff3	colony observation	(none)	age of mouse at death (local parameter) [d] age_end 10325	inbred w/CC7	40	both		N=10

Tordoff3:26	Tordoff3	DXA	(none)	bone mineral density (BMD) [g/cm²] BMD 10326	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3:27	Tordoff3	DXA	(none)	bone mineral content (BMC) [g] BMC 10327	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3:28	Tordoff3	DXA	(none)	weight of lean tissue, head excluded [g] lean_wt 10328	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3:29	Tordoff3	DXA	(none)	weight of fat tissue, head excluded [g] fat_wt 10329	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3:30	Tordoff3	DXA	(none)	total weight (lean + fat), head excluded [g] total_wt 10330	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3:31	Tordoff3	DXA	(none)	percent fat, head excluded [%] pct_fat 10331	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3:32	Tordoff3	DXA	(none)	percent lean, head excluded [%] pct_lean 10332	inbred w/CC7	40	both	14-18wks	N=10

Tordoff3: Diet preference: Survey of calcium and sodium intake, blood pH and calcium level, and bone and body composition data in 40 inbred strains of mice (2002)

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