Tordoff3: Diet preference: Survey of calcium and sodium intake, blood pH and calcium level, and bone and body composition data in 40 inbred strains of mice (2002)

References   (chronological)

1.   Tordoff MG, Bachmanov AA, Reed DR. Forty mouse strain survey of water and sodium intake. Physiol Behav. 2007 Aug 15;91(5):620-31. Epub 2007 Apr 1.   PubMed 17490693  

2.   Tordoff MG, Bachmanov AA, Reed DR. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav. 2007 Aug 15;91(5):632-43. Epub 2007 Apr 1.   PubMed 17493644  

3.   Reed DR, Bachmanov AA, Tordoff MG. Forty mouse strain survey of body composition. Physiol Behav. 2007 Aug 15;91(5):593-600. Epub 2007 Apr 1.   PubMed 17493645  


       
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Participants Michael G Tordoff       Monell Chemical Senses Center Philadelphia, PA
Alexander A Bachmanov       Monell Chemical Senses Center Philadelphia, PA
ContactMichael G Tordoff     tordoff@monell.org     Lab web site
AffiliationMonell Chemical Senses Center
AcknowledgementsFunding provided by NIH DK46791 and AA12715

Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program. Funding for the PIXImus II densitometer was provided by Commonwealth of Pennsylvania Health Research Formula Grant #ME-02-169.

Technical help provided by Pilchak D, Williams J, Rudolph K, St. Germain N, Belton D, Doman S, Duble T, and Byerly E.
Project type Phenotype strain survey data set
MPD identifiersTordoff3     MPD:103
Data changelog 3 updates/corrections.       Initial release date: 11/2002.
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Animals were evaluated using Ciba-Corning calcium analyzer and PIXImus II mouse densitometer (DXA).

Summary of procedures that were conducted
• body weight
• bottle choice test Various salt solutions (several concentrations) vs. water.
• DXA Body mass, fat mass, lean mass, bone mineral density and content.
• metabolic panel Ionized and total blood calcium, blood pH.
• monitoring system Bleeding time to collect approx 30 µL.
Mice: inbred w/CC7   40 strains   ♀♂   age 9-15wks   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Tordoff3 10305 body weight (none) body weight   [g]     start    end    Δchange inbred w/CC7 40 both 8-10wks N=10
    Tordoff3 10308 bottle choice test (none) preference for CaCl2 (calcium chloride) solutions   [%]     7.5mM    25    75 inbred w/CC7 40 both 9-11wks N=10
    Tordoff3 10311 bottle choice test (none) preference for CaLa (calcium lactate) solutions   [%]     7.5mM    25    75 inbred w/CC7 40 both 10-12wks N=10
    Tordoff3 10314 bottle choice test (none) preference for NaCl (sodium chloride) solutions   [%]     25mM    75    225 inbred w/CC7 40 both 11-13wks N=10
    Tordoff3 10317 bottle choice test (none) preference for NaLa (sodium lactate) solutions   [%]     25mM    75    225 inbred w/CC7 40 both 12-14wks N=10
    Tordoff3 10321 metabolic panel (none) blood ionized calcium   [mg/dL]  ionized_Ca inbred w/CC7 40 both 13-15wks N=10
    Tordoff3 10322 metabolic panel (none) blood pH   [pH]  pH inbred w/CC7 40 both 13-15wks N=10
    Tordoff3 10323 metabolic panel (none) blood ionized calcium adjusted to pH 7.4   [mg/dL]  adj_ionized_Ca inbred w/CC7 40 both 13-15wks N=10
    Tordoff3 10324 metabolic panel (none) plasma total calcium   [mg/dL]  total_calcium inbred w/CC7 40 both 13-15wks N=10
    Tordoff3 10326 DXA (none) bone mineral density (BMD)   [g/cm2]  BMD inbred w/CC7 40 both 14-18wks N=10
    Tordoff3 10327 DXA (none) bone mineral content (BMC)   [g]  BMC inbred w/CC7 40 both 14-18wks N=10
    Tordoff3 10328 DXA (none) weight of lean tissue, head excluded   [g]  lean_wt inbred w/CC7 40 both 14-18wks N=10
    Tordoff3 10329 DXA (none) weight of fat tissue, head excluded   [g]  fat_wt inbred w/CC7 40 both 14-18wks N=10
    Tordoff3 10330 DXA (none) total weight (lean + fat), head excluded   [g]  total_wt inbred w/CC7 40 both 14-18wks N=10
    Tordoff3 10331 DXA (none) percent fat, head excluded   [%]  pct_fat inbred w/CC7 40 both 14-18wks N=10
    Tordoff3 10332 DXA (none) percent lean, head excluded   [%]  pct_lean inbred w/CC7 40 both 14-18wks N=10
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