MPD: Project measures / variables set: Paigen2 TG

Project measures / variables set: Paigen2 TG

ID, description, units	MPD:9921 TG triglycerides (plasma, 4h fast) [mg/dL] high-fat diet study
Measures	• baseline • after 17wks on diet • Δchange
Data set, strains	Paigen2 inbred w/CC7 42 strains sex: both age: 7-9wks
Procedure	lipid profile
Comparison	repeated measures, baseline then treated, same cohort
Ontology mappings	VT:0002644 blood triglyceride amount MA:0002501 plasma MP:0011969 abnormal circulating triglyceride level

Values Means Δ Means Z-scores

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Paigen2 - triglycerides (plasma, 4h fast)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	16987.8006	16987.8006	7.8611	0.0053
between strain	33	1918073.0102	58123.4246	26.8966	< 0.0001
between sex:strain	33	300502.537	9106.1375	4.2139	< 0.0001
between Residuals	483	1043761.3509	2160.9966
within group	1	415183.3938	415183.3938	177.0194	< 0.0001
within group:sex	1	1969.3879	1969.3879	0.8397	0.3599
within group:strain	33	1327570.3039	40229.4031	17.1524	< 0.0001
within group:sex:strain	33	186429.9567	5649.3926	2.4087	< 0.0001
within Residuals	483	1132833.9577	2345.4119

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Paigen2	9921	lipid profile	high-fat diet	triglycerides (plasma, 4h fast) [mg/dL] baseline TG	inbred w/CC7	42	both	7-9wks
Paigen2	9922	lipid profile	high-fat diet	triglycerides (plasma, 4h fast) [mg/dL] after 17wks on diet TG_fat17	inbred w/CC7	41	both	7-9wks
Paigen2	9923	lipid profile	high-fat diet	triglycerides (plasma, 4h fast) [mg/dL] fold change TG_chg	inbred w/CC7	41	both	7-9wks	(supplemental / summary measure)