Project measure / variable:   Paigen2   aortic_lesion

ID, description, units MPD:9924   aortic_lesion   fatty streak aortic lesion size   [µm2]  
high-fat diet study
Data set, strains Paigen2   inbred w/CC7   42 strains     sex: both     age: 25-27wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen2 - fatty streak aortic lesion size



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested42 strains39 strains
Mean of the strain means630   µm2 490   µm2
Median of the strain means17.6   µm2 0   µm2
SD of the strain means± 1374 ± 1556
Coefficient of variation (CV)2.18 3.18
Min–max range of strain means0   –   6712   µm2 0   –   8406   µm2
Mean sample size per strain9.0   mice 8.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7090738.117 7090738.117 3.3031 0.0697
strain 38 1146112867.5558 30160864.9357 14.0499 < 0.0001
sex:strain 38 290202124.815 7636898.0214 3.5575 < 0.0001
Residuals 593 1272989120.2097 2146693.2887


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.0 0.0   10 0.0 0.0 -0.46
129S1/SvImJ m 0.0 0.0   10 0.0 0.0 -0.31
A/J f 0.0 0.0   10 0.0 0.0 -0.46
A/J m 1041.0 1710.0   8 605.0 1.64 0.35
AKR/J f 0.0 0.0   11 0.0 0.0 -0.46
BALB/cByJ f 409.0 425.0   10 134.0 1.04 -0.16
BALB/cByJ m 288.0 573.0   9 191.0 1.99 -0.13
BALB/cJ f 982.0 904.0   9 301.0 0.92 0.26
BALB/cJ m 105.0 212.0   9 70.8 2.02 -0.25
BTBR T+ Itpr3tf/J f 1655.0 1975.0   10 624.0 1.19 0.75
BTBR T+ Itpr3tf/J m 0.0 0.0   9 0.0 0.0 -0.31
BUB/BnJ f 238.0 674.0   9 225.0 2.83 -0.29
BUB/BnJ m 0.0 0.0   7 0.0 0.0 -0.31
C3H/HeJ f 0.0 0.0   9 0.0 0.0 -0.46
C3H/HeJ m 33.0 87.3   7 33.0 2.65 -0.29
C57BL/10J f 0.0 0.0   9 0.0 0.0 -0.46
C57BL/10J m 0.0 0.0   9 0.0 0.0 -0.31
C57BL/6J f 41.2 124.0   9 41.2 3.0 -0.43
C57BL/6J m 97.0 180.0   8 63.5 1.85 -0.25
C57BLKS/J f 3613.0 3399.0   8 1202.0 0.941 2.17
C57BLKS/J m 5098.0 2731.0   5 1221.0 0.536 1760.0, 8893.0 2.96
C57BR/cdJ f 1931.0 2705.0   9 902.0 1.4 0.95
C57BR/cdJ m 0.0 0.0   11 0.0 0.0 -0.31
C57L/J f 0.0 0.0   10 0.0 0.0 -0.46
C57L/J m 0.0 0.0   8 0.0 0.0 -0.31
C58/J f 4632.0 4230.0   10 1338.0 0.913 2.91
C58/J m 8406.0 7733.0   9 2578.0 0.92 291.0, 21829.0 5.09
CAST/EiJ f 17.0 48.1   8 17.0 2.83 -0.45
CAST/EiJ m 0.0 0.0   7 0.0 0.0 -0.31
CBA/J f 0.0 0.0   10 0.0 0.0 -0.46
CBA/J m 0.0 0.0   8 0.0 0.0 -0.31
CZECHII/EiJ f 0.0 0.0   11 0.0 0.0 -0.46
CZECHII/EiJ m 0.0 0.0   9 0.0 0.0 -0.31
DBA/1J f 96.2 198.0   8 70.1 2.06 -0.39
DBA/1J m 0.0 0.0   8 0.0 0.0 -0.31
DBA/2J f 0.0 0.0   9 0.0 0.0 -0.46
DBA/2J m 0.0 0.0   9 0.0 0.0 -0.31
FVB/NJ f 0.0 0.0   8 0.0 0.0 -0.46
FVB/NJ m 128.0 286.0   5 128.0 2.24 -0.23
I/LnJ f 866.0 1824.0   9 608.0 2.11 0.17
I/LnJ m 374.0 548.0   8 194.0 1.46 -0.07
JF1/MsJ f 0.0 0.0   10 0.0 0.0 -0.46
JF1/MsJ m 0.0 0.0   6 0.0 0.0 -0.31
KK/HlJ f 0.0 0.0   8 0.0 0.0 -0.46
LP/J f 166.0 361.0   10 114.0 2.18 -0.34
LP/J m 61.8 197.0   14 52.6 3.19 -0.28
MA/MyJ f 639.0 989.0   10 313.0 1.55 0.01
MA/MyJ m 0.0 0.0   10 0.0 0.0 -0.31
MOLF/EiJ f 521.0 922.0   7 348.0 1.77 -0.08
MOLF/EiJ m 984.0 1073.0   8 379.0 1.09 0.32
MSM/MsJ f 0.0 0.0   5 0.0 0.0 -0.46
MSM/MsJ m 0.0 0.0   11 0.0 0.0 -0.31
NOD/ShiLtJ f 30.7 81.3   7 30.7 2.65 -0.44
NOD/ShiLtJ m 0.0 0.0   5 0.0 0.0 -0.31
NON/ShiLtJ f 1859.0 2457.0   9 819.0 1.32 0.89
NON/ShiLtJ m 1463.0 1780.0   14 476.0 1.22 0.63
NZB/BlNJ f 11.5 36.4   10 11.5 3.16 -0.45
NZB/BlNJ m 136.0 212.0   7 80.3 1.56 -0.23
NZW/LacJ f 0.0 0.0   9 0.0 0.0 -0.46
NZW/LacJ m 0.0 0.0   10 0.0 0.0 -0.31
PERA/EiJ f 0.0 0.0   9 0.0 0.0 -0.46
PERA/EiJ m 0.0 0.0   7 0.0 0.0 -0.31
PL/J f 0.0 0.0   9 0.0 0.0 -0.46
PL/J m 0.0 0.0   5 0.0 0.0 -0.31
PWK/PhJ f 0.0 0.0   9 0.0 0.0 -0.46
PWK/PhJ m 0.0 0.0   8 0.0 0.0 -0.31
RF/J f 18.3 48.4   7 18.3 2.65 -0.45
RIIIS/J f 37.2 112.0   9 37.2 3.0 -0.43
RIIIS/J m 183.0 313.0   7 118.0 1.71 -0.2
SEA/GnJ f 1159.0 1056.0   9 352.0 0.911 0.39
SEA/GnJ m 0.0 0.0   10 0.0 0.0 -0.31
SJL/J f 0.0 0.0   10 0.0 0.0 -0.46
SJL/J m 0.0 0.0   10 0.0 0.0 -0.31
SM/J f 6712.0 5275.0   9 1758.0 0.786 779.0, 17561.0 4.43
SM/J m 124.0 328.0   7 124.0 2.65 -0.24
SPRET/EiJ f 0.0 0.0   4 0.0 0.0 -0.46
SPRET/EiJ m 103.0 229.0   5 103.0 2.24 -0.25
SWR/J f 773.0 1323.0   7 500.0 1.71 0.1
SWR/J m 481.0 1178.0   6 481.0 2.45 -0.01
WSB/EiJ f 47.2 170.0   13 47.2 3.61 -0.42
WSB/EiJ m 0.0 0.0   8 0.0 0.0 -0.31


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.0 463.3242 909.956 -909.956
129S1/SvImJ m 0.0 463.3242 909.956 -909.956
A/J f 0.0 463.3242 909.956 -909.956
A/J m 1041.25 518.0122 2058.6117 23.8883
BALB/cByJ f 409.3 463.3242 1319.256 -500.656
BALB/cByJ m 288.0 488.3866 1247.1779 -671.1779
BALB/cJ f 981.8889 488.3866 1941.0667 22.711
BALB/cJ m 105.2222 488.3866 1064.4001 -853.9556
BTBR T+ Itpr3tf/J f 1654.6 463.3242 2564.556 744.644
BTBR T+ Itpr3tf/J m 0.0 488.3866 959.1779 -959.1779
BUB/BnJ f 238.4444 488.3866 1197.6223 -720.7334
BUB/BnJ m 0.0 553.7784 1087.6055 -1087.6055
C3H/HeJ f 0.0 488.3866 959.1779 -959.1779
C3H/HeJ m 33.0 553.7784 1120.6055 -1054.6055
C57BL/10J f 0.0 488.3866 959.1779 -959.1779
C57BL/10J m 0.0 488.3866 959.1779 -959.1779
C57BL/6J f 41.2222 488.3866 1000.4001 -917.9556
C57BL/6J m 97.0 518.0122 1114.3617 -920.3617
C57BLKS/J f 3612.75 518.0122 4630.1117 2595.3883
C57BLKS/J m 5097.8 655.2394 6384.6721 3810.9279
C57BR/cdJ f 1931.4444 488.3866 2890.6223 972.2666
C57BR/cdJ m 0.0 441.7623 867.609 -867.609
C57L/J f 0.0 463.3242 909.956 -909.956
C57L/J m 0.0 518.0122 1017.3617 -1017.3617
C58/J f 4631.9 463.3242 5541.856 3721.944
C58/J m 8406.1111 488.3866 9365.289 7446.9333
CAST/EiJ f 17.0 518.0122 1034.3617 -1000.3617
CAST/EiJ m 0.0 553.7784 1087.6055 -1087.6055
CBA/J f 0.0 463.3242 909.956 -909.956
CBA/J m 0.0 518.0122 1017.3617 -1017.3617
CZECHII/EiJ f 0.0 441.7623 867.609 -867.609
CZECHII/EiJ m 0.0 488.3866 959.1779 -959.1779
DBA/1J f 96.25 518.0122 1113.6117 -921.1117
DBA/1J m 0.0 518.0122 1017.3617 -1017.3617
DBA/2J f 0.0 488.3866 959.1779 -959.1779
DBA/2J m 0.0 488.3866 959.1779 -959.1779
FVB/NJ f 0.0 518.0122 1017.3617 -1017.3617
FVB/NJ m 127.8 655.2394 1414.6721 -1159.0721
I/LnJ f 865.8889 488.3866 1825.0667 -93.289
I/LnJ m 373.875 518.0122 1391.2367 -643.4867
JF1/MsJ f 0.0 463.3242 909.956 -909.956
JF1/MsJ m 0.0 598.149 1174.7482 -1174.7482
LP/J f 165.8 463.3242 1075.756 -744.156
LP/J m 61.7857 391.5804 830.8389 -707.2675
MA/MyJ f 638.7 463.3242 1548.656 -271.256
MA/MyJ m 0.0 463.3242 909.956 -909.956
MOLF/EiJ f 520.7143 553.7784 1608.3197 -566.8912
MOLF/EiJ m 983.75 518.0122 2001.1117 -33.6117
MSM/MsJ f 0.0 655.2394 1286.8721 -1286.8721
MSM/MsJ m 0.0 441.7623 867.609 -867.609
NOD/ShiLtJ f 30.7143 553.7784 1118.3197 -1056.8912
NOD/ShiLtJ m 0.0 655.2394 1286.8721 -1286.8721
NON/ShiLtJ f 1858.6667 488.3866 2817.8445 899.4888
NON/ShiLtJ m 1462.7857 391.5804 2231.8389 693.7325
NZB/BlNJ f 11.5 463.3242 921.456 -898.456
NZB/BlNJ m 136.4286 553.7784 1224.034 -951.1769
NZW/LacJ f 0.0 488.3866 959.1779 -959.1779
NZW/LacJ m 0.0 463.3242 909.956 -909.956
PERA/EiJ f 0.0 488.3866 959.1779 -959.1779
PERA/EiJ m 0.0 553.7784 1087.6055 -1087.6055
PL/J f 0.0 488.3866 959.1779 -959.1779
PL/J m 0.0 655.2394 1286.8721 -1286.8721
PWK/PhJ f 0.0 488.3866 959.1779 -959.1779
PWK/PhJ m 0.0 518.0122 1017.3617 -1017.3617
RIIIS/J f 37.2222 488.3866 996.4001 -921.9556
RIIIS/J m 182.5714 553.7784 1270.1769 -905.034
SEA/GnJ f 1159.2222 488.3866 2118.4001 200.0444
SEA/GnJ m 0.0 463.3242 909.956 -909.956
SJL/J f 0.0 463.3242 909.956 -909.956
SJL/J m 0.0 463.3242 909.956 -909.956
SM/J f 6712.1111 488.3866 7671.289 5752.9333
SM/J m 123.8571 553.7784 1211.4626 -963.7483
SPRET/EiJ f 0.0 732.5799 1438.7668 -1438.7668
SPRET/EiJ m 102.6 655.2394 1389.4721 -1184.2721
SWR/J f 772.5714 553.7784 1860.1769 -315.034
SWR/J m 480.8333 598.149 1655.5815 -693.9148
WSB/EiJ f 47.2308 406.3622 845.315 -750.8534
WSB/EiJ m 0.0 518.0122 1017.3617 -1017.3617


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.0 327.6197 643.4361 -643.4361
A/J both 520.625 347.4932 1203.092 -161.842
BALB/cByJ both 348.65 336.5972 1009.7177 -312.4177
BALB/cJ both 543.5556 345.3415 1221.7967 -134.6856
BTBR T+ Itpr3tf/J both 827.3 336.5972 1488.3677 166.2323
BUB/BnJ both 119.2222 369.1856 844.2925 -605.8481
C3H/HeJ both 16.5 369.1856 741.5703 -708.5703
C57BL/10J both 0.0 345.3415 678.2412 -678.2412
C57BL/6J both 69.1111 355.9699 768.2261 -630.0039
C57BLKS/J both 4355.275 417.6348 5175.4983 3535.0517
C57BR/cdJ both 965.7222 329.2702 1612.3998 319.0446
C57L/J both 0.0 347.4932 682.467 -682.467
C58/J both 6519.0056 336.5972 7180.0733 5857.9378
CAST/EiJ both 8.5 379.1461 753.1326 -736.1326
CBA/J both 0.0 347.4932 682.467 -682.467
CZECHII/EiJ both 0.0 329.2702 646.6776 -646.6776
DBA/1J both 48.125 366.29 767.5084 -671.2584
DBA/2J both 0.0 345.3415 678.2412 -678.2412
FVB/NJ both 63.9 417.6348 884.1233 -756.3233
I/LnJ both 619.8819 355.9699 1318.9969 -79.233
JF1/MsJ both 0.0 378.3026 742.976 -742.976
LP/J both 113.7929 303.3169 709.4989 -481.9132
MA/MyJ both 319.35 327.6197 962.7861 -324.0861
MOLF/EiJ both 752.2321 379.1461 1496.8647 7.5996
MSM/MsJ both 0.0 395.1242 776.0131 -776.0131
NOD/ShiLtJ both 15.3571 428.9549 857.8127 -827.0984
NON/ShiLtJ both 1660.7262 312.9923 2275.4344 1046.0179
NZB/BlNJ both 73.9643 361.0193 782.9963 -635.0677
NZW/LacJ both 0.0 336.5972 661.0677 -661.0677
PERA/EiJ both 0.0 369.1856 725.0703 -725.0703
PL/J both 0.0 408.6136 802.5058 -802.5058
PWK/PhJ both 0.0 355.9699 699.115 -699.115
RIIIS/J both 109.8968 369.1856 834.9671 -615.1735
SEA/GnJ both 579.6111 336.5972 1240.6788 -81.4566
SJL/J both 0.0 327.6197 643.4361 -643.4361
SM/J both 3417.9841 369.1856 4143.0544 2692.9138
SPRET/EiJ both 51.3 491.4295 1016.4541 -913.8541
SWR/J both 626.7024 407.5698 1427.1583 -173.7536
WSB/EiJ both 23.6154 329.191 670.1375 -622.9067




  GWAS USING LINEAR MIXED MODELS