MPD: Project measures / variables set: Paigen2 HDLC

Project measures / variables set: Paigen2 HDLC

ID, description, units	MPD:9904 HDLC HDL cholesterol (plasma) [mg/dL] high-fat diet study
Measures	• baseline • after 17wks on diet • Δchange
Data set, strains	Paigen2 inbred w/CC7 42 strains sex: both age: 7-9wks
Procedure	lipid profile
Comparison	repeated measures, baseline then treated, same cohort
Ontology mappings	VT:0000184 blood HDL cholesterol amount MA:0002501 plasma MP:0000184 abnormal circulating HDL cholesterol level

Values Means Δ Means Z-scores

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Paigen2 - HDL cholesterol (plasma)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	50174.5182	50174.5182	144.8739	< 0.0001
between strain	33	584520.9225	17712.7552	51.1438	< 0.0001
between sex:strain	33	69266.2034	2098.9759	6.0606	< 0.0001
between Residuals	511	176975.8729	346.3324
within group	1	104323.0033	104323.0033	308.6443	< 0.0001
within group:sex	1	4661.8614	4661.8614	13.7923	0.0002
within group:strain	33	165256.2112	5007.764	14.8157	< 0.0001
within group:sex:strain	33	31916.8923	967.1786	2.8614	< 0.0001
within Residuals	511	172720.0241	338.004

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Paigen2	9904	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] baseline HDLC	inbred w/CC7	42	both	7-9wks
Paigen2	9907	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] after 17wks on diet HDLC_fat17	inbred w/CC7	41	both	7-9wks
Paigen2	9910	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] fold change HDLC_chg	inbred w/CC7	41	both	7-9wks	(supplemental / summary measure)