Project measure / variable:   Berndt2   airway_res_mch10

ID, description, units MPD:35184   airway_res_mch10   airway resistance (H20 pressure)   [cm/mL/s]  10 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt2 - airway resistance (H20 pressure) 10 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means1.09   cm/mL/s 1.29   cm/mL/s
Median of the strain means1.15   cm/mL/s 1.32   cm/mL/s
SD of the strain means± 0.362 ± 0.310
Coefficient of variation (CV)0.333 0.240
Min–max range of strain means0.539   –   2.28   cm/mL/s 0.739   –   2.08   cm/mL/s
Mean sample size per strain8.6   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5.4321 5.4321 38.7853 < 0.0001
strain 28 46.1471 1.6481 11.7675 < 0.0001
sex:strain 28 10.3426 0.3694 2.6374 < 0.0001
Residuals 457 64.0054 0.1401


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.612 0.102   9 0.0339 0.166 0.48, 0.79 -1.32
129S1/SvImJ m 0.78 0.379   8 0.134 0.486 0.48, 1.68 -1.65
A/J f 1.42 0.444   10 0.14 0.313 0.84, 2.29 0.91
A/J m 1.78 0.574   9 0.191 0.322 0.79, 2.61 1.58
AKR/J f 1.01 0.198   9 0.066 0.196 0.74, 1.31 -0.22
AKR/J m 1.59 0.343   8 0.121 0.216 0.99, 2.05 0.97
BALB/cByJ f 1.01 0.493   8 0.174 0.488 0.54, 1.91 -0.22
BALB/cByJ m 1.42 0.672   8 0.238 0.472 0.79, 2.69 0.42
BALB/cJ f 0.982 0.0963   8 0.0341 0.098 0.85, 1.12 -0.3
BALB/cJ m 1.42 0.495   10 0.157 0.349 0.82, 2.49 0.42
BTBR T+ Itpr3tf/J f 1.31 0.338   10 0.107 0.258 0.64, 1.82 0.61
BTBR T+ Itpr3tf/J m 1.34 0.348   10 0.11 0.26 0.86, 1.9 0.16
BUB/BnJ f 1.39 0.195   9 0.0651 0.141 1.06, 1.64 0.83
BUB/BnJ m 1.39 0.475   10 0.15 0.341 0.66, 2.32 0.32
C3H/HeJ f 1.2 0.285   10 0.0901 0.237 0.75, 1.59 0.31
C3H/HeJ m 1.28 0.206   9 0.0688 0.162 0.84, 1.53 -0.03
C57BL/10J f 0.724 0.15   9 0.0501 0.208 0.57, 1.05 -1.01
C57BL/10J m 1.06 0.167   10 0.0527 0.157 0.86, 1.42 -0.74
C57BL/6J f 0.539 0.172   8 0.0606 0.318 0.32, 0.81 -1.52
C57BL/6J m 1.08 0.283   8 0.0999 0.263 0.59, 1.41 -0.68
C57BLKS/J f 0.866 0.188   9 0.0626 0.217 0.65, 1.17 -0.62
C57BLKS/J m 1.35 0.423   12 0.122 0.312 0.68, 2.01 0.19
C57BR/cdJ f 1.22 0.534   6 0.218 0.44 0.72, 2.2 0.36
C57BR/cdJ m 1.27 0.535   10 0.169 0.42 0.64, 2.57 -0.07
C57L/J f 1.24 0.546   6 0.223 0.439 0.81, 2.09 0.42
C57L/J m 1.02 0.303   10 0.0958 0.298 0.51, 1.42 -0.87
CBA/J f 1.13 0.402   8 0.142 0.356 0.79, 2.03 0.11
CBA/J m 1.07 0.34   10 0.108 0.319 0.73, 1.94 -0.71
CE/J f 1.25 0.276   9 0.0921 0.22 0.93, 1.7 0.44
CE/J m 1.14 0.283   9 0.0943 0.247 0.74, 1.7 -0.49
DBA/1J f 1.43 0.391   9 0.13 0.273 0.81, 2.0 0.94
DBA/1J m 1.47 0.619   10 0.196 0.422 0.65, 2.48 0.58
DBA/2J f 0.9 0.239   10 0.0755 0.265 0.63, 1.33 -0.52
DBA/2J m 1.32 0.302   10 0.0955 0.229 0.98, 1.88 0.1
FVB/NJ f 1.15 0.311   10 0.0984 0.271 0.44, 1.5 0.17
FVB/NJ m 1.32 0.856   10 0.271 0.648 0.38, 2.76 0.1
I/LnJ f 1.57 0.315   5 0.141 0.201 1.16, 2.03 1.33
I/LnJ m 1.57 0.511   8 0.181 0.324 0.65, 2.16 0.9
KK/HlJ f 2.28 0.635   9 0.212 0.278 1.21, 3.31 3.29
KK/HlJ m 2.08 0.532   10 0.168 0.255 1.36, 2.84 2.55
LP/J f 0.622 0.118   9 0.0394 0.19 0.47, 0.84 -1.29
LP/J m 1.32 0.226   10 0.0714 0.172 1.09, 1.8 0.1
NOD/ShiLtJ f 0.884 0.183   9 0.0611 0.207 0.5, 1.16 -0.57
NOD/ShiLtJ m 1.65 0.561   9 0.187 0.34 0.95, 2.46 1.16
NON/ShiLtJ f 1.2 0.112   7 0.0425 0.0938 1.0, 1.32 0.31
NON/ShiLtJ m 1.06 0.191   7 0.0723 0.181 0.72, 1.24 -0.74
NZW/LacJ f 0.684 0.195   8 0.069 0.286 0.44, 0.99 -1.12
NZW/LacJ m 0.739 0.219   10 0.0692 0.296 0.46, 1.09 -1.78
PL/J f 1.19 0.28   9 0.0935 0.235 0.7, 1.69 0.28
PL/J m 1.74 0.267   8 0.0943 0.153 1.28, 2.16 1.45
RIIIS/J f 1.2 0.264   6 0.108 0.221 0.88, 1.56 0.31
RIIIS/J m 0.931 0.279   9 0.0929 0.299 0.54, 1.36 -1.16
SJL/J f 0.689 0.104   8 0.0369 0.151 0.56, 0.87 -1.1
SJL/J m 1.23 0.456   9 0.152 0.372 0.66, 1.87 -0.2
SM/J f 1.21 0.288   10 0.0912 0.238 0.89, 1.74 0.33
SM/J m 1.2 0.216   8 0.0762 0.18 0.88, 1.45 -0.29
SWR/J f 0.673 0.13   9 0.0434 0.193 0.49, 0.89 -1.15
SWR/J m 0.805 0.272   10 0.0861 0.338 0.53, 1.27 -1.57


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.6122 0.1247 0.8574 0.3671
129S1/SvImJ m 0.78 0.1323 1.04 0.52
A/J f 1.419 0.1183 1.6516 1.1864
A/J m 1.7789 0.1247 2.024 1.5337
AKR/J f 1.0111 0.1247 1.2563 0.766
AKR/J m 1.5938 0.1323 1.8538 1.3337
BALB/cByJ f 1.01 0.1323 1.27 0.75
BALB/cByJ m 1.4225 0.1323 1.6825 1.1625
BALB/cJ f 0.9825 0.1323 1.2425 0.7225
BALB/cJ m 1.417 0.1183 1.6496 1.1844
BTBR T+ Itpr3tf/J f 1.31 0.1183 1.5426 1.0774
BTBR T+ Itpr3tf/J m 1.339 0.1183 1.5716 1.1064
BUB/BnJ f 1.3856 0.1247 1.6307 1.1404
BUB/BnJ m 1.393 0.1183 1.6256 1.1604
C3H/HeJ f 1.203 0.1183 1.4356 0.9704
C3H/HeJ m 1.2767 0.1247 1.5218 1.0315
C57BL/10J f 0.7244 0.1247 0.9696 0.4793
C57BL/10J m 1.062 0.1183 1.2946 0.8294
C57BL/6J f 0.5388 0.1323 0.7988 0.2787
C57BL/6J m 1.0763 0.1323 1.3363 0.8162
C57BLKS/J f 0.8656 0.1247 1.1107 0.6204
C57BLKS/J m 1.355 0.108 1.5673 1.1427
C57BR/cdJ f 1.215 0.1528 1.5152 0.9148
C57BR/cdJ m 1.274 0.1183 1.5066 1.0414
C57L/J f 1.2433 0.1528 1.5436 0.9431
C57L/J m 1.017 0.1183 1.2496 0.7844
CBA/J f 1.1275 0.1323 1.3875 0.8675
CBA/J m 1.066 0.1183 1.2986 0.8334
CE/J f 1.2544 0.1247 1.4996 1.0093
CE/J m 1.1444 0.1247 1.3896 0.8993
DBA/1J f 1.4322 0.1247 1.6774 1.1871
DBA/1J m 1.466 0.1183 1.6986 1.2334
DBA/2J f 0.9 0.1183 1.1326 0.6674
DBA/2J m 1.318 0.1183 1.5506 1.0854
FVB/NJ f 1.149 0.1183 1.3816 0.9164
FVB/NJ m 1.321 0.1183 1.5536 1.0884
I/LnJ f 1.566 0.1674 1.8949 1.2371
I/LnJ m 1.575 0.1323 1.835 1.315
KK/HlJ f 2.2822 0.1247 2.5274 2.0371
KK/HlJ m 2.085 0.1183 2.3176 1.8524
LP/J f 0.6222 0.1247 0.8674 0.3771
LP/J m 1.317 0.1183 1.5496 1.0844
NOD/ShiLtJ f 0.8844 0.1247 1.1296 0.6393
NOD/ShiLtJ m 1.6478 0.1247 1.8929 1.4026
NON/ShiLtJ f 1.1986 0.1414 1.4765 0.9206
NON/ShiLtJ m 1.0571 0.1414 1.3351 0.7792
NZW/LacJ f 0.6838 0.1323 0.9438 0.4237
NZW/LacJ m 0.739 0.1183 0.9716 0.5064
PL/J f 1.1911 0.1247 1.4363 0.946
PL/J m 1.7425 0.1323 2.0025 1.4825
RIIIS/J f 1.195 0.1528 1.4952 0.8948
RIIIS/J m 0.9311 0.1247 1.1763 0.686
SJL/J f 0.6888 0.1323 0.9488 0.4287
SJL/J m 1.2256 0.1247 1.4707 0.9804
SM/J f 1.211 0.1183 1.4436 0.9784
SM/J m 1.2 0.1323 1.46 0.94
SWR/J f 0.6733 0.1247 0.9185 0.4282
SWR/J m 0.805 0.1183 1.0376 0.5724


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.6961 0.0909 0.8748 0.5174
A/J both 1.5989 0.086 1.7679 1.43
AKR/J both 1.3024 0.0909 1.4811 1.1237
BALB/cByJ both 1.2163 0.0936 1.4001 1.0324
BALB/cJ both 1.1997 0.0888 1.3742 1.0253
BTBR T+ Itpr3tf/J both 1.3245 0.0837 1.489 1.16
BUB/BnJ both 1.3893 0.086 1.5582 1.2203
C3H/HeJ both 1.2398 0.086 1.4088 1.0709
C57BL/10J both 0.8932 0.086 1.0622 0.7243
C57BL/6J both 0.8075 0.0936 0.9914 0.6236
C57BLKS/J both 1.1103 0.0825 1.2724 0.9481
C57BR/cdJ both 1.2445 0.0966 1.4344 1.0546
C57L/J both 1.1302 0.0966 1.3201 0.9403
CBA/J both 1.0967 0.0888 1.2712 0.9223
CE/J both 1.1994 0.0882 1.3728 1.0261
DBA/1J both 1.4491 0.086 1.6181 1.2802
DBA/2J both 1.109 0.0837 1.2735 0.9445
FVB/NJ both 1.235 0.0837 1.3995 1.0705
I/LnJ both 1.5705 0.1067 1.7801 1.3609
KK/HlJ both 2.1836 0.086 2.3526 2.0147
LP/J both 0.9696 0.086 1.1386 0.8007
NOD/ShiLtJ both 1.2661 0.0882 1.4395 1.0928
NON/ShiLtJ both 1.1279 0.1 1.3244 0.9313
NZW/LacJ both 0.7114 0.0888 0.8858 0.5369
PL/J both 1.4668 0.0909 1.6455 1.2881
RIIIS/J both 1.0631 0.0986 1.2569 0.8692
SJL/J both 0.9572 0.0909 1.1358 0.7785
SM/J both 1.2055 0.0888 1.3799 1.0311
SWR/J both 0.7392 0.086 0.9081 0.5702




  GWAS USING LINEAR MIXED MODELS