Project measure / variable:   Berndt2   airway_res_mch30

ID, description, units MPD:35185   airway_res_mch30   airway resistance (H20 pressure)   [cm/mL/s]  30 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt2 - airway resistance (H20 pressure) 30 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested28 strains28 strains
Mean of the strain means1.57   cm/mL/s 1.81   cm/mL/s
Median of the strain means1.67   cm/mL/s 1.85   cm/mL/s
SD of the strain means± 0.448 ± 0.337
Coefficient of variation (CV)0.286 0.186
Min–max range of strain means0.654   –   2.46   cm/mL/s 1.11   –   2.37   cm/mL/s
Mean sample size per strain7.0   mice 5.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7.4753 7.4753 36.0427 < 0.0001
strain 25 35.1097 1.4044 6.7713 < 0.0001
sex:strain 25 12.9687 0.5187 2.5012 0.0002
Residuals 285 59.1094 0.2074


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.897 0.293   9 0.0978 0.327 0.5, 1.39 -1.49
129S1/SvImJ m 1.11 0.427   7 0.161 0.386 0.54, 1.6 -2.09
A/J f 2.17 0.751   6 0.307 0.345 1.44, 3.59 1.35
A/J m 2.24 0.0   1   0.0 0.0 2.24, 2.24 1.27
AKR/J f 1.7 0.422   9 0.141 0.249 1.02, 2.33 0.3
AKR/J m 1.87 1.23   2   0.87 0.658 1.0, 2.74 0.17
BALB/cByJ f 1.23 0.183   5 0.0819 0.148 0.99, 1.48 -0.75
BALB/cByJ m 1.88 0.609   6 0.249 0.324 1.28, 2.58 0.2
BALB/cJ f 1.66 0.4   5 0.179 0.241 1.21, 2.24 0.21
BALB/cJ m 2.28 0.586   7 0.221 0.257 1.63, 3.36 1.39
BTBR T+ Itpr3tf/J f 1.77 0.744   4 0.372 0.421 1.01, 2.79 0.46
BTBR T+ Itpr3tf/J m 1.83 0.284   5 0.127 0.155 1.43, 2.09 0.05
BUB/BnJ f 2.13 0.418   8 0.148 0.196 1.54, 2.74 1.26
BUB/BnJ m 2.04 0.566   5 0.253 0.277 1.26, 2.5 0.67
C3H/HeJ f 1.64 0.287   7 0.108 0.175 1.18, 2.01 0.17
C3H/HeJ m 1.95 0.383   5 0.171 0.196 1.54, 2.37 0.41
C57BL/10J f 0.91 0.175   8 0.0618 0.192 0.62, 1.16 -1.46
C57BL/10J m 1.82 0.125   6 0.051 0.0688 1.64, 2.0 0.02
C57BL/6J f 0.654 0.184   7 0.0696 0.282 0.42, 0.96 -2.03
C57BL/6J m 1.45 0.658   5 0.294 0.455 0.61, 2.18 -1.08
C57BLKS/J f 1.52 0.456   6 0.186 0.301 1.01, 2.23 -0.1
C57BLKS/J m 2.13 0.628   6 0.256 0.295 1.26, 3.13 0.94
C57BR/cdJ f 1.81 0.51   4 0.255 0.282 1.15, 2.38 0.55
C57BR/cdJ m 1.54 0.311   8 0.11 0.202 1.16, 2.1 -0.81
C57L/J f 1.68 0.42   4 0.21 0.25 1.37, 2.3 0.26
C57L/J m 1.59 0.48   9 0.16 0.303 0.96, 2.49 -0.66
CBA/J f 1.64 0.584   8 0.206 0.355 0.87, 2.43 0.17
CBA/J m 1.74 0.458   9 0.153 0.264 1.22, 2.51 -0.22
CE/J f 2.04 0.607   9 0.202 0.297 1.08, 2.87 1.06
CE/J m 2.37 0.481   9 0.16 0.203 1.62, 2.99 1.65
DBA/1J f 2.02 0.332   2   0.235 0.165 1.78, 2.25 1.02
DBA/1J m 1.45 0.253   3 0.146 0.175 1.22, 1.72 -1.08
DBA/2J f 1.72 0.633   9 0.211 0.369 0.93, 3.15 0.35
DBA/2J m 1.93 0.494   3 0.285 0.256 1.38, 2.33 0.35
FVB/NJ f 1.71 0.284   10 0.0897 0.166 1.24, 2.14 0.32
FVB/NJ m 1.44 0.5   6 0.204 0.348 0.84, 2.24 -1.11
I/LnJ m 2.12 0.458   3 0.265 0.216 1.7, 2.61 0.91
KK/HlJ f 2.46 0.874   6 0.357 0.355 1.23, 3.7 2.0
LP/J f 1.01 0.176   8 0.0621 0.174 0.82, 1.28 -1.24
LP/J m 2.19 0.252   3 0.145 0.115 2.03, 2.48 1.12
NOD/ShiLtJ f 1.7 0.478   7 0.181 0.281 1.25, 2.4 0.3
NOD/ShiLtJ m 2.09 0.757   6 0.309 0.362 0.82, 2.95 0.82
NON/ShiLtJ f 1.79 0.292   7 0.11 0.163 1.46, 2.33 0.5
NON/ShiLtJ m 2.02 0.263   7 0.0992 0.13 1.61, 2.44 0.61
NZW/LacJ f 1.42 0.67   7 0.253 0.472 0.75, 2.2 -0.32
NZW/LacJ m 1.5 0.614   9 0.205 0.409 0.84, 2.63 -0.93
PL/J f 1.44 0.187   9 0.0622 0.129 1.07, 1.71 -0.28
PL/J m 2.24 0.392   6 0.16 0.175 1.64, 2.7 1.27
RIIIS/J f 1.78 0.534   5 0.239 0.299 1.06, 2.45 0.48
RIIIS/J m 1.43 0.389   6 0.159 0.273 1.08, 2.18 -1.14
SJL/J f 0.804 0.217   8 0.0767 0.27 0.52, 1.23 -1.7
SJL/J m 1.71 0.432   6 0.176 0.253 0.9, 2.0 -0.31
SM/J f 1.62 0.446   10 0.141 0.275 1.09, 2.42 0.12
SM/J m 1.46 0.285   3 0.165 0.195 1.17, 1.74 -1.05
SWR/J f 0.901 0.124   8 0.0439 0.138 0.71, 1.12 -1.48
SWR/J m 1.35 0.686   7 0.259 0.509 0.51, 2.58 -1.38


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.8967 0.1518 1.1955 0.5979
129S1/SvImJ m 1.1057 0.1721 1.4445 0.7669
AKR/J f 1.6978 0.1518 1.9966 1.399
AKR/J m 1.87 0.322 2.5039 1.2361
BALB/cByJ f 1.234 0.2037 1.6349 0.8331
BALB/cByJ m 1.8767 0.1859 2.2426 1.5107
BALB/cJ f 1.664 0.2037 2.0649 1.2631
BALB/cJ m 2.2829 0.1721 2.6217 1.944
BTBR T+ Itpr3tf/J f 1.7675 0.2277 2.2157 1.3193
BTBR T+ Itpr3tf/J m 1.826 0.2037 2.2269 1.4251
BUB/BnJ f 2.135 0.161 2.4519 1.8181
BUB/BnJ m 2.042 0.2037 2.4429 1.6411
C3H/HeJ f 1.6371 0.1721 1.976 1.2983
C3H/HeJ m 1.95 0.2037 2.3509 1.5491
C57BL/10J f 0.91 0.161 1.2269 0.5931
C57BL/10J m 1.815 0.1859 2.181 1.449
C57BL/6J f 0.6543 0.1721 0.9931 0.3155
C57BL/6J m 1.448 0.2037 1.8489 1.0471
C57BLKS/J f 1.5167 0.1859 1.8826 1.1507
C57BLKS/J m 2.1267 0.1859 2.4926 1.7607
C57BR/cdJ f 1.8075 0.2277 2.2557 1.3593
C57BR/cdJ m 1.5375 0.161 1.8544 1.2206
C57L/J f 1.6825 0.2277 2.1307 1.2343
C57L/J m 1.5856 0.1518 1.8844 1.2868
CBA/J f 1.6425 0.161 1.9594 1.3256
CBA/J m 1.7378 0.1518 2.0366 1.439
CE/J f 2.0444 0.1518 2.3432 1.7456
CE/J m 2.3656 0.1518 2.6644 2.0668
DBA/1J f 2.015 0.322 2.6489 1.3811
DBA/1J m 1.4467 0.2629 1.9642 0.9291
DBA/2J f 1.7156 0.1518 2.0144 1.4168
DBA/2J m 1.9333 0.2629 2.4509 1.4158
FVB/NJ f 1.705 0.144 1.9885 1.4215
FVB/NJ m 1.4383 0.1859 1.8043 1.0724
LP/J f 1.0075 0.161 1.3244 0.6906
LP/J m 2.19 0.2629 2.7075 1.6725
NOD/ShiLtJ f 1.7029 0.1721 2.0417 1.364
NOD/ShiLtJ m 2.0917 0.1859 2.4576 1.7257
NON/ShiLtJ f 1.7914 0.1721 2.1302 1.4526
NON/ShiLtJ m 2.0229 0.1721 2.3617 1.684
NZW/LacJ f 1.4214 0.1721 1.7602 1.0826
NZW/LacJ m 1.4989 0.1518 1.7977 1.2001
PL/J f 1.4433 0.1518 1.7421 1.1445
PL/J m 2.2417 0.1859 2.6076 1.8757
RIIIS/J f 1.784 0.2037 2.1849 1.3831
RIIIS/J m 1.4267 0.1859 1.7926 1.0607
SJL/J f 0.8038 0.161 1.1207 0.4868
SJL/J m 1.7083 0.1859 2.0743 1.3424
SM/J f 1.622 0.144 1.9055 1.3385
SM/J m 1.4633 0.2629 1.9809 0.9458
SWR/J f 0.9013 0.161 1.2182 0.5843
SWR/J m 1.3471 0.1721 1.686 1.0083


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.0012 0.1148 1.2271 0.7753
AKR/J both 1.7839 0.178 2.1343 1.4335
BALB/cByJ both 1.5553 0.1379 1.8267 1.2839
BALB/cJ both 1.9734 0.1333 2.2359 1.711
BTBR T+ Itpr3tf/J both 1.7968 0.1528 2.0974 1.4961
BUB/BnJ both 2.0885 0.1298 2.344 1.833
C3H/HeJ both 1.7936 0.1333 2.056 1.5311
C57BL/10J both 1.3625 0.123 1.6046 1.1204
C57BL/6J both 1.0511 0.1333 1.3136 0.7887
C57BLKS/J both 1.8217 0.1315 2.0804 1.5629
C57BR/cdJ both 1.6725 0.1394 1.947 1.398
C57L/J both 1.634 0.1368 1.9034 1.3647
CBA/J both 1.6901 0.1106 1.9079 1.4724
CE/J both 2.205 0.1073 2.4163 1.9937
DBA/1J both 1.7308 0.2079 2.14 1.3217
DBA/2J both 1.8244 0.1518 2.1232 1.5256
FVB/NJ both 1.5717 0.1176 1.8031 1.3402
LP/J both 1.5988 0.1542 1.9022 1.2953
NOD/ShiLtJ both 1.8973 0.1267 2.1466 1.6479
NON/ShiLtJ both 1.9071 0.1217 2.1467 1.6676
NZW/LacJ both 1.4602 0.1148 1.686 1.2343
PL/J both 1.8425 0.12 2.0787 1.6063
RIIIS/J both 1.6053 0.1379 1.8767 1.3339
SJL/J both 1.256 0.123 1.4981 1.014
SM/J both 1.5427 0.1499 1.8377 1.2476
SWR/J both 1.1242 0.1178 1.3562 0.8922




  GWAS USING LINEAR MIXED MODELS