Project measure / variable:   Berndt1   airway_res_mch30

ID, description, units MPD:34214   airway_res_mch30   airway resistance (H2O pressure)   [cm/mL/s]  MCh challenge 30 mg/mL  
methacholine study
Data set, strains Berndt1   inbred   37 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt1 - airway resistance (H2O pressure) MCh challenge 30 mg/mL



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested35 strains31 strains
Mean of the strain means1.59   cm/mL/s 1.77   cm/mL/s
Median of the strain means1.66   cm/mL/s 1.82   cm/mL/s
SD of the strain means± 0.453 ± 0.333
Coefficient of variation (CV)0.285 0.188
Min–max range of strain means0.654   –   2.46   cm/mL/s 1.11   –   2.37   cm/mL/s
Mean sample size per strain7.0   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7.2553 7.2553 34.3641 < 0.0001
strain 28 37.8 1.35 6.3941 < 0.0001
sex:strain 28 13.7876 0.4924 2.3323 0.0002
Residuals 327 69.0401 0.2111


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.897 0.293   9 0.0978 0.327 0.5, 1.39 -1.53
129S1/SvImJ m 1.11 0.427   7 0.161 0.386 0.54, 1.6 -1.98
A/J f 2.17 0.751   6 0.307 0.345 1.44, 3.59 1.28
AKR/J f 1.7 0.422   9 0.141 0.249 1.02, 2.33 0.24
AKR/J m 1.87 1.23   2   0.87 0.658 1.0, 2.74 0.3
BALB/cByJ f 1.23 0.183   5 0.0819 0.148 0.99, 1.48 -0.79
BALB/cByJ m 1.88 0.609   6 0.249 0.324 1.28, 2.58 0.33
BALB/cJ f 1.66 0.4   5 0.179 0.241 1.21, 2.24 0.16
BALB/cJ m 2.28 0.586   7 0.221 0.257 1.63, 3.36 1.53
BPN/3J f 1.1 0.449   8 0.159 0.407 0.51, 1.82 -1.08
BTBR T+ Itpr3tf/J f 1.77 0.744   4 0.372 0.421 1.01, 2.79 0.4
BTBR T+ Itpr3tf/J m 1.83 0.284   5 0.127 0.155 1.43, 2.09 0.18
BUB/BnJ f 2.13 0.418   8 0.148 0.196 1.54, 2.74 1.19
BUB/BnJ m 2.04 0.566   5 0.253 0.277 1.26, 2.5 0.81
C3H/HeJ f 1.64 0.287   7 0.108 0.175 1.18, 2.01 0.11
C3H/HeJ m 1.95 0.383   5 0.171 0.196 1.54, 2.37 0.54
C57BL/10J f 0.91 0.175   8 0.0618 0.192 0.62, 1.16 -1.5
C57BL/10J m 1.82 0.125   6 0.051 0.0688 1.64, 2.0 0.15
C57BL/6J f 0.654 0.184   7 0.0696 0.282 0.42, 0.96 -2.06
C57BL/6J m 1.45 0.658   5 0.294 0.455 0.61, 2.18 -0.96
C57BLKS/J f 1.52 0.456   6 0.186 0.301 1.01, 2.23 -0.15
C57BLKS/J m 2.13 0.628   6 0.256 0.295 1.26, 3.13 1.08
C57BR/cdJ f 1.81 0.51   4 0.255 0.282 1.15, 2.38 0.49
C57BR/cdJ m 1.54 0.311   8 0.11 0.202 1.16, 2.1 -0.69
C57L/J f 1.68 0.42   4 0.21 0.25 1.37, 2.3 0.2
C57L/J m 1.59 0.48   9 0.16 0.303 0.96, 2.49 -0.54
CBA/J f 1.64 0.584   8 0.206 0.355 0.87, 2.43 0.11
CBA/J m 1.74 0.458   9 0.153 0.264 1.22, 2.51 -0.09
CE/J f 2.04 0.607   9 0.202 0.297 1.08, 2.87 0.99
CE/J m 2.37 0.481   9 0.16 0.203 1.62, 2.99 1.8
DBA/1J f 2.02 0.332   2   0.235 0.165 1.78, 2.25 0.95
DBA/1J m 1.45 0.253   3 0.146 0.175 1.22, 1.72 -0.96
DBA/2J f 1.72 0.633   9 0.211 0.369 0.93, 3.15 0.29
DBA/2J m 1.96 0.406   4 0.203 0.208 1.38, 2.33 0.57
FVB/NJ f 1.71 0.284   10 0.0897 0.166 1.24, 2.14 0.27
FVB/NJ m 1.44 0.5   6 0.204 0.348 0.84, 2.24 -0.99
I/LnJ m 2.12 0.458   3 0.265 0.216 1.7, 2.61 1.05
KK/HlJ f 2.46 0.874   6 0.357 0.355 1.23, 3.7 1.92
LG/J f 1.58 0.53   9 0.177 0.335 0.83, 2.38 -0.02
LG/J m 1.56 0.497   9 0.166 0.319 0.93, 2.43 -0.63
LP/J f 1.01 0.176   8 0.0621 0.174 0.82, 1.28 -1.28
LP/J m 2.19 0.252   3 0.145 0.115 2.03, 2.48 1.26
MA/MyJ f 2.35 0.7   5 0.313 0.297 1.61, 3.28 1.68
MRL/MpJ f 1.98 0.389   7 0.147 0.197 1.54, 2.51 0.86
MRL/MpJ m 1.98 0.591   9 0.197 0.298 1.21, 2.98 0.63
NOD/ShiLtJ f 1.7 0.478   7 0.181 0.281 1.25, 2.4 0.24
NOD/ShiLtJ m 2.09 0.757   6 0.309 0.362 0.82, 2.95 0.96
NON/ShiLtJ f 1.79 0.292   7 0.11 0.163 1.46, 2.33 0.44
NON/ShiLtJ m 2.02 0.263   7 0.0992 0.13 1.61, 2.44 0.75
NZB/BlNJ m 1.21 0.536   10 0.17 0.445 0.74, 2.37 -1.68
NZO/HlLtJ f 2.2 0.41   9 0.137 0.186 1.31, 2.63 1.35
NZW/LacJ f 1.42 0.67   7 0.253 0.472 0.75, 2.2 -0.37
NZW/LacJ m 1.5 0.614   9 0.205 0.409 0.84, 2.63 -0.81
P/J f 1.17 0.181   5 0.081 0.155 0.92, 1.39 -0.92
P/J m 1.52 0.543   7 0.205 0.357 0.88, 2.52 -0.75
PL/J f 1.44 0.187   9 0.0622 0.129 1.07, 1.71 -0.33
PL/J m 2.24 0.392   6 0.16 0.175 1.64, 2.7 1.41
PWD/PhJ f 1.41 0.4   6 0.163 0.284 0.97, 2.13 -0.39
RIIIS/J f 1.78 0.534   5 0.239 0.299 1.06, 2.45 0.42
RIIIS/J m 1.43 0.389   6 0.159 0.273 1.08, 2.18 -1.02
SJL/J f 0.804 0.217   8 0.0767 0.27 0.52, 1.23 -1.73
SJL/J m 1.71 0.432   6 0.176 0.253 0.9, 2.0 -0.18
SM/J f 1.62 0.446   10 0.141 0.275 1.09, 2.42 0.07
SM/J m 1.46 0.285   3 0.165 0.195 1.17, 1.74 -0.93
SWR/J f 0.901 0.124   8 0.0439 0.138 0.71, 1.12 -1.52
SWR/J m 1.39 0.645   8 0.228 0.465 0.51, 2.58 -1.14


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.8967 0.1532 1.198 0.5954
129S1/SvImJ m 1.1057 0.1737 1.4474 0.7641
AKR/J f 1.6978 0.1532 1.9991 1.3965
AKR/J m 1.87 0.3249 2.5092 1.2308
BALB/cByJ f 1.234 0.2055 1.6383 0.8297
BALB/cByJ m 1.8767 0.1876 2.2457 1.5076
BALB/cJ f 1.664 0.2055 2.0683 1.2597
BALB/cJ m 2.2829 0.1737 2.6245 1.9412
BTBR T+ Itpr3tf/J f 1.7675 0.2297 2.2195 1.3155
BTBR T+ Itpr3tf/J m 1.826 0.2055 2.2303 1.4217
BUB/BnJ f 2.135 0.1625 2.4546 1.8154
BUB/BnJ m 2.042 0.2055 2.4463 1.6377
C3H/HeJ f 1.6371 0.1737 1.9788 1.2955
C3H/HeJ m 1.95 0.2055 2.3543 1.5457
C57BL/10J f 0.91 0.1625 1.2296 0.5904
C57BL/10J m 1.815 0.1876 2.184 1.446
C57BL/6J f 0.6543 0.1737 0.9959 0.3126
C57BL/6J m 1.448 0.2055 1.8523 1.0437
C57BLKS/J f 1.5167 0.1876 1.8857 1.1476
C57BLKS/J m 2.1267 0.1876 2.4957 1.7576
C57BR/cdJ f 1.8075 0.2297 2.2595 1.3555
C57BR/cdJ m 1.5375 0.1625 1.8571 1.2179
C57L/J f 1.6825 0.2297 2.1345 1.2305
C57L/J m 1.5856 0.1532 1.8869 1.2842
CBA/J f 1.6425 0.1625 1.9621 1.3229
CBA/J m 1.7378 0.1532 2.0391 1.4365
CE/J f 2.0444 0.1532 2.3458 1.7431
CE/J m 2.3656 0.1532 2.6669 2.0642
DBA/1J f 2.015 0.3249 2.6542 1.3758
DBA/1J m 1.4467 0.2653 1.9686 0.9248
DBA/2J f 1.7156 0.1532 2.0169 1.4142
DBA/2J m 1.9575 0.2297 2.4095 1.5055
FVB/NJ f 1.705 0.1453 1.9908 1.4192
FVB/NJ m 1.4383 0.1876 1.8074 1.0693
LG/J f 1.5833 0.1532 1.8846 1.282
LG/J m 1.5578 0.1532 1.8591 1.2565
LP/J f 1.0075 0.1625 1.3271 0.6879
LP/J m 2.19 0.2653 2.7119 1.6681
MRL/MpJ f 1.9771 0.1737 2.3188 1.6355
MRL/MpJ m 1.9844 0.1532 2.2858 1.6831
NOD/ShiLtJ f 1.7029 0.1737 2.0445 1.3612
NOD/ShiLtJ m 2.0917 0.1876 2.4607 1.7226
NON/ShiLtJ f 1.7914 0.1737 2.1331 1.4498
NON/ShiLtJ m 2.0229 0.1737 2.3645 1.6812
NZW/LacJ f 1.4214 0.1737 1.7631 1.0798
NZW/LacJ m 1.4989 0.1532 1.8002 1.1976
P/J f 1.17 0.2055 1.5743 0.7657
P/J m 1.52 0.1737 1.8617 1.1783
PL/J f 1.4433 0.1532 1.7446 1.142
PL/J m 2.2417 0.1876 2.6107 1.8726
RIIIS/J f 1.784 0.2055 2.1883 1.3797
RIIIS/J m 1.4267 0.1876 1.7957 1.0576
SJL/J f 0.8037 0.1625 1.1233 0.4842
SJL/J m 1.7083 0.1876 2.0774 1.3393
SM/J f 1.622 0.1453 1.9078 1.3362
SM/J m 1.4633 0.2653 1.9852 0.9414
SWR/J f 0.9012 0.1625 1.2208 0.5817
SWR/J m 1.3887 0.1625 1.7083 1.0692


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.0012 0.1158 1.229 0.7734
AKR/J both 1.7839 0.1796 2.1372 1.4306
BALB/cByJ both 1.5553 0.1391 1.829 1.2817
BALB/cJ both 1.9734 0.1345 2.2381 1.7088
BTBR T+ Itpr3tf/J both 1.7967 0.1541 2.0999 1.4936
BUB/BnJ both 2.0885 0.131 2.3462 1.8308
C3H/HeJ both 1.7936 0.1345 2.0582 1.5289
C57BL/10J both 1.3625 0.1241 1.6066 1.1184
C57BL/6J both 1.0511 0.1345 1.3158 0.7865
C57BLKS/J both 1.8217 0.1326 2.0826 1.5607
C57BR/cdJ both 1.6725 0.1407 1.9493 1.3957
C57L/J both 1.634 0.1381 1.9056 1.3624
CBA/J both 1.6901 0.1116 1.9098 1.4705
CE/J both 2.205 0.1083 2.4181 1.9919
DBA/1J both 1.7308 0.2097 2.1434 1.3182
DBA/2J both 1.8365 0.1381 2.1081 1.5649
FVB/NJ both 1.5717 0.1186 1.8051 1.3383
LG/J both 1.5706 0.1083 1.7836 1.3575
LP/J both 1.5988 0.1555 1.9047 1.2928
MRL/MpJ both 1.9808 0.1158 2.2086 1.753
NOD/ShiLtJ both 1.8973 0.1278 2.1487 1.6458
NON/ShiLtJ both 1.9071 0.1228 2.1487 1.6656
NZW/LacJ both 1.4602 0.1158 1.6879 1.2324
P/J both 1.345 0.1345 1.6096 1.0804
PL/J both 1.8425 0.1211 2.0807 1.6043
RIIIS/J both 1.6053 0.1391 1.879 1.3317
SJL/J both 1.256 0.1241 1.5001 1.012
SM/J both 1.5427 0.1512 1.8402 1.2451
SWR/J both 1.145 0.1149 1.371 0.919




  GWAS USING LINEAR MIXED MODELS