Wiltshire4: Toxicity of four anti-cancer agents tested in vitro in immune cells from 36 inbred mouse strains (2015)

Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS, Wiltshire T. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med. 2015 Feb 26;8:81-98. doi: 10.2147/PGPM.S73312. eCollection 2015.   PubMed 25897258     FullText


       
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Participants Tim Wiltshire       University of North Carolina Chapel Hill, NC
With: Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS
ContactTim Wiltshire     timw@unc.edu     Lab web site
Project type Phenotype strain survey data set
MPD identifiersWiltshire4     MPD:524
Data changelog No updates/corrections.       Initial release date: 01/2016.
Formatted citation
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The anti-cancer agents studied are: BEZ235, doxorubicin, idarubicin, and selumetinib. Cells were harvested from 4 mice per strain. The investigators normalized the individual animal data such that the controls for each strain / drug / cell analysis group averaged out to 100.0.

Summary of procedures that were conducted
• immune cell quantification In vitro study of 4 cancer chemotherapies vs. control. Effect on immune cells. Normalized data.
Mice: inbred   36 strains   ♂   age 10wks   0 cohorts

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Wiltshire4 52401 immune cell quantification BEZ235 B cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 52407 immune cell quantification BEZ235 T cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 52413 immune cell quantification BEZ235 monocytes, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 52421 immune cell quantification doxorubicin B cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 52427 immune cell quantification doxorubicin T cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 52433 immune cell quantification doxorubicin monocytes, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 52441 immune cell quantification idarubicin B cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 52447 immune cell quantification idarubicin T cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 52453 immune cell quantification idarubicin monocytes, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 52461 immune cell quantification selumetinib B cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 52467 immune cell quantification selumetinib T cells, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 52473 immune cell quantification selumetinib monocytes, percent viability   [%]     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
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