Wiltshire4: Toxicity of four anti-cancer agents tested in vitro in immune cells from 36 inbred mouse strains (2015)

Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS, Wiltshire T. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med. 2015 Feb 26;8:81-98. doi: 10.2147/PGPM.S73312. eCollection 2015.   PubMed 25897258     FullText

Wiltshire4 downloads
• Download Wiltshire4 project data set     animal data, as uploaded
• Download Wiltshire4 animal data matrix     with factor-related expansion applied as necessary
• Download Wiltshire4 strain means, SD, N, etc.     one row per strain/sex/measure
• Wiltshire4 supplementary data
Investigators Tim Wiltshire       University of North Carolina,  Chapel Hill, NC
Participants Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS
ContactTim Wiltshire     timw@unc.edu     Lab web site
Project type Phenotype strain survey data set
MPD identifiersWiltshire4     MPD:524
Data changelog No updates/corrections.       Initial release date: 01/2016.
Formatted citation
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The anti-cancer agents studied are: BEZ235, doxorubicin, idarubicin, and selumetinib. Cells were harvested from 4 mice per strain. The investigators normalized the individual animal data such that the controls for each strain / drug / cell analysis group averaged out to 100.0.

Experimental groups in this study:
• BEZ235     • Doxorubicin     • Idarubicin     • Selumetinib    

Procedures conducted:
• immune cell quantification  In vitro study of 4 cancer chemotherapies (BEZ235, doxorubicin, idarubicin, selumetinib) vs. control. Effect on immune cells. Normalized data.

Mice: inbred w/CC7   36 strains   ♂   age 10wks   4 experimental groups