Moy1: Investigation of autism-relevant behaviors in males of 17 inbred strains of mice (2008)

Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res. 2007 Jan 10;176(1):4-20. Epub 2006 Sep 12.   PubMed 16971002     FullText

Moy SS, Nadler JJ, Young NB, Nonneman RJ, Segall SK, Andrade GM, Crawley JN, Magnuson TR. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res. 2008 Aug 5;191(1):118-29. Epub 2008 Mar 21.   PubMed 18440079     FullText


         
An investigation of autism-modelling possibilities. The hallmark signs of human autism include aberrant social interactions, deficits in communication, and rigid, repetitive behaviors. Autistic-like behaviors were assessed in mice using an automated 3-chambered social test apparatus. Shortly after a period of habituation to the social test box, mice were evaluated for sociability in the presence of an unfamiliar mouse,
Sociability test   Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus (an unfamiliar mouse) versus a novel object (an empty wire cage).

Preference for social novelty test   Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus (a newly-presented unfamiliar mouse) versus a former social stimulus (an already-investigated mouse). and then tested for social novelty preference by adding a second, less-familiar conspecific mouse to the apparatus.

Procedures conducted:

• three chamber assay  Sociability and preference for social novelty. Autism-relevant behaviors.

Moy1 downloads
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Investigators Sheryl S Moy       University of North Carolina,  Chapel Hill, NC
Jacqueline N Crawley       National Institute of Mental Health,  Bethesda, MD
Jean M Lauder       University of North Carolina,  Chapel Hill, NC
Jessica J Nadler       University of North Carolina,  Chapel Hill, NC
David W Threadgill       Texas A&M University,  College Station, TX
Terry R Magnuson       University of North Carolina,  Chapel Hill, NC
Participants Young NB, Perez A, Nonneman RJ
ContactTerry R Magnuson     trm4@med.unc.edu     Lab web site
AcknowledgementsFunding provided by NIH MH66418, HD03110; NIMH Intramural Research Program

Dr. Joseph Piven, Director of the Carolina Institute for Developmental Disabilities, provided valuable insights throughout the project.
Project type Phenotype strain survey data set
MPD identifiersMoy1     MPD:301
Data changelog No updates/corrections.       Initial release date: 02/2009.
Formatted citation
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Mice: inbred   17 strains   ♂   age 6-7wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Moy1 three chamber assay (none) time spent in chamber with stranger 1 (a novel mouse), 10 min test   [s]  DurSTR1_soc   30101 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent in chamber with empty cage (a novel object), 10 min test   [s]  DurOBJ_soc   30102 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent in center chamber, 10 min test   [s]  DurCEN_soc   30103 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent sniffing cage with stranger1 (a novel mouse), 10 min test   [s]  SnSTR1_soc   30104 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent sniffing empty cage (a novel object), 10 min test   [s]  SnOBJ_soc   30105 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) number of entries into chamber with stranger1 (a novel mouse), 10 min test   [n]  EntSTR1_soc   30106 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) number of entries into chamber with empty cage (a novel object), 10 min test   [n]  EntOBJ_soc   30107 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent in chamber with stranger1 (former novel mouse), 10 min test   [s]  DurSTR1_nov   30108 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent in chamber with stranger 2 (a second novel mouse), 10 min test   [s]  DurSTR2_nov   30109 inbred 17 m 6-7wks N=22
    Moy1 three chamber assay (none) time spent in center chamber, 10 min test   [s]  DurCEN_nov   30110 inbred 17 m 6-7wks N=22
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