MPD: Data set: Kas1

de Mooij-van Malsen JG, Yu KL, Veldman H, Oppelaar H, van den Berg LH, Olivier B, Kas MJ. Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice. Neuroscience. 2009 Dec 29;164(4):1477-83. Epub 2009 Sep 22. PubMed 19778584

Kas1 downloads
• Download Kas1 project data set animal data, as uploaded
• Download Kas1 animal data matrix with factor-related expansion applied as necessary
• Download Kas1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Kas1 measures:

MA:0000233 spinal nerve
MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001516 abnormal motor coordination/balance
MP:0003107 abnormal response to novelty
MP:0003993 abnormal ventral spinal root morphology
MP:0005404 abnormal axon morphology
MP:0013189 abnormal exploration in a new environment
VT:0001392 locomotor behavior trait
VT:0001516 motor coordination/balance trait
VT:0005404 axon morphology trait
VT:0010459 behavioral response to novel environment trait
VT:0010471 exploratory behavior trait
VT:0010716 anxiety-related behavior trait

Investigators	Martien JH Kas University Medical Center - Utrecht, Utrecht NETHERLANDS JG de Mooij-van Malsen University Medical Center - Utrecht, Utrecht NETHERLANDS
Participants	JG, Yu KL, Veldman H, Oppelaar H, van den Berg LH, Olivier B
Contact	Martien JH Kas m.j.h.kas@umcutrecht.nl Lab web site
Acknowledgements	Funding provided by ABC Neurogenomics Program of Utrecht University; University Medical Centre Utrecht (Grant 03-12)
Project type	Phenotype strain survey data set
MPD identifiers	Kas1 MPD:344
Data changelog	No updates/corrections. Initial release date: 08/2010.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

An investigation of relationships between motor neuron anatomy and motor activity.

Procedures conducted:

• balance beam		Latency to reach target.
• grid test		Inverted grid performance.
• home cage monitoring		Locomotor activity.
• microscopy		Ventral root axon morphology. Nervous system microscopy.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Kas1:1	Kas1	microscopy	(none)	size, area of total ventral root [µm²] area_ventral_root 34401	inbred	6	m	22-31wks	N=4

Kas1:2	Kas1	microscopy	(none)	number of axons per ventral root (calculated) [n] total_axon 34402	inbred	6	m	22-31wks	N=4

Kas1:3	Kas1	microscopy	(none)	size, area of median axon [µm²] area_median_axon 34403	inbred	6	m	22-31wks	N=6

Kas1:4	Kas1	microscopy	(none)	percent of 0-50 µm² axons [%] pct_axon50 34404	inbred	6	m	22-31wks	N=6

Kas1:5	Kas1	microscopy	(none)	percent of 50-100 µm² axons [%] pct_axon100 34405	inbred	6	m	22-31wks	N=6

Kas1:6	Kas1	microscopy	(none)	percent of 100-150 µm² axons [%] pct_axon150 34406	inbred	6	m	22-31wks	N=6

Kas1:7	Kas1	microscopy	(none)	percent of 150-200 µm² axons [%] pct_axon200 34407	inbred	6	m	22-31wks	N=6

Kas1:8	Kas1	home cage monitoring	(none)	total locomotor activity, first hour in novel home cage [cm] tot_act_1h 34408	inbred	6	m	22-31wks	N=16

Kas1:9	Kas1	home cage monitoring	(none)	total locomotor activity, day 3 (24 h) in home cage [cm] tot_act_D3 34409	inbred	6	m	22-31wks	N=16

Kas1:10	Kas1	balance beam	(none)	latency to reach box via a narrow beam [s] latency_BB 34410	inbred	6	m	22-31wks	N=6

Kas1:11	Kas1	grid test	(none)	latency to fall, 5 min on inverted grid [s] latency_grid 34411	inbred	6	m	22-31wks	N=6

Kas1:12	Kas1	grid test	(none)	number of alternating hindlimb movement, 5 min on inverted grid [n] hindlimb_movement 34412	inbred	6	m	22-31wks	N=6

Kas1:13	Kas1	grid test	(none)	percent of alternating hindlimb movement, 5 min on inverted grid [%] pct_movement 34413	inbred	6	m	22-31wks	N=6

Kas1:14	Kas1	microscopy	(none)	number of axons per region of interest (6000 µm²) [n] axon 34414	inbred	6	m	22-31wks	N=6

Kas1: Variations in ventral root axon morphology and locomotor behavior in males of 6 inbred strains of mice (2009)