Haston1: Susceptibility to radiation-induced fibrotic lung disease in 26 inbred strains of mice (2012)

Paun A, Haston CK. Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice. Radiother Oncol. 2012 Dec;105(3):350-7. doi: 10.1016/j.radonc.2012.08.004. Epub 2012 Sep 4.   PubMed 22954495  


       
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Participants Christina K Haston       McGill University Montreal, Quebec CANADA
With: Paun A
ContactChristina K Haston     christina.haston@mcgill.ca     Lab web site
AcknowledgementsFunding provided by Canadian Institutes of Health Research (#MOP62846); Fonds de la Recherche en Sante Quebec
Project type Phenotype strain survey data set
MPD identifiersHaston1     MPD:488
Data changelog No updates/corrections.       Initial release date: 09/2013.
Formatted citation
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Mice were exposed at 8-10 wks of age to 18 Gy whole thorax irradiation and monitored for up to 26 weeks. Survival (respiratory distress), bronchoalveolar cell differential, and histological alveolitis and fibrosis phenotypes were determined. There is one cohort; control data are mentioned in the primary publication.

Summary of procedures that were conducted
• health assessment Survival rate and health assessment after exposure to radiation. Number of days without respiratory distress (max 26 wks).
• bronchoalveolar lavage assessment Bronchoalveolar cell differential after exposure to radiation.
• histopathology Post exposure to radiation.
Mice: inbred   26 strains   ♀♂   age 15-36wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Haston1 48801 health assessment radiation number of days in the absence of respiratory distress   [d]  survival inbred 20 both 15-36wks N=7
    Haston1 48802 histopathology radiation percentage of lung surface covered by fibrotic scar   [%]  fibrosis inbred 20 both 15-36wks N=6
    Haston1 48803 bronchoalveolar lavage assessment radiation percentage of macrophages in bronchoalveolar lavage   [%]  BAL_mac inbred 20 both 15-36wks N=6
    Haston1 48804 bronchoalveolar lavage assessment radiation percentage of lymphocytes in bronchoalveolar lavage   [%]  BAL_lym inbred 20 both 15-36wks N=6
    Haston1 48805 bronchoalveolar lavage assessment radiation percentage of neutrophils in bronchoalveolar lavage   [%]  BAL_neut inbred 20 both 15-36wks N=6
    Haston1 48806 histopathology radiation average number of mast cells per mm2 of lung tissue   [n]  mast_cells inbred 19 both 15-36wks N=6
    Haston1 48807 histopathology radiation inflammation index (0=no alveolitis, 6=severe alveolitis)   [score]  alveolitis inbred 20 both 15-36wks N=7
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