Haston1: Susceptibility to radiation-induced fibrotic lung disease in 26 inbred strains of mice (2012)

Paun A, Haston CK. Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice. Radiother Oncol. 2012 Dec;105(3):350-7. doi: 10.1016/j.radonc.2012.08.004. Epub 2012 Sep 4.   PubMed 22954495  


       
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Participants Christina K Haston       McGill University Montreal, Quebec CANADA
With: Paun A
ContactChristina K Haston     christina.haston@mcgill.ca     Lab web site
AcknowledgementsFunding provided by Canadian Institutes of Health Research (#MOP62846); Fonds de la Recherche en Sante Quebec
Project type Phenotype strain survey data set
MPD identifiersHaston1     MPD:488
Data changelog No updates/corrections.       Initial release date: 09/2013.
Formatted citation
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Mice were exposed at 8-10 wks of age to 18 Gy whole thorax irradiation and monitored for up to 26 weeks. Survival (respiratory distress), bronchoalveolar cell differential, and histological alveolitis and fibrosis phenotypes were determined. There is one cohort; control data are mentioned in the primary publication.

Summary of procedures that were conducted
• health assessment Survival rate and health assessment after exposure to radiation. Number of days without respiratory distress (max 26 wks).
• bronchoalveolar lavage assessment Bronchoalveolar cell differential after exposure to radiation (18 Gy).
• histopathology Post exposure to radiation.
Mice: inbred   26 strains   ♀♂   age 15-36wks   1 cohort