HMDPpheno4: Fear conditioning in males of 94 strains of mice in the Hybrid Mouse Diversity Panel (HMDP) (2011)

Park CC, Gale GD, de Jong S, Ghazalpour A, Bennett BJ, Farber CR, Langfelder P, Lin A, Khan AH, Eskin E, Horvath S, Lusis AJ, Ophoff RA, Smith DJ. Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol. 2011 Mar 16;5:43. doi: 10.1186/1752-0509-5-43.   PubMed 21410935     FullText


       
HMDPpheno4 downloads
• Download HMDPpheno4 project data set     one row per animal, one column per trait
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• HMDPpheno4 supplementary data
Participants Christopher C Park       University of California, Los Angeles Los Angeles, CA
Greg D Gale       University of California, Los Angeles Los Angeles, CA
Aldons J Lusis       University of California, Los Angeles Los Angeles, CA
Desmond J Smith       University of California, Los Angeles Los Angeles, CA
With: Khan AH, de Jong S, Ghazalpour A, Bennett BJ, Farber CR, Langfelder P, Lin A, Eskin E, Horvath S, Ophoff RA
ContactDesmond J Smith     dsmith@mednet.ucla.edu     Lab web site
AffiliationHybrid Mouse Diversity Panel Group (HMDP)
AcknowledgementsFunding provided by NIH MH071779
Project type Phenotype strain survey data set
MPD identifiersHMDPpheno4     MPD:468
Data changelog No updates/corrections.       Initial release date: 04/2013.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An associated gene expression study is available in GEO: GSE26500

Summary of procedures that were conducted
• fear conditioning test Contextual fear, cued fear.
Mice: HMDP   94 strains including progenitors   ♂   age 10wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    HMDPpheno4 46801 fear conditioning test (none) fear training, percent time spent near chamber walls, day1   [%]     pre-stimulus    post-stimulus HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46811 fear conditioning test (none) fear training, velocity, day 1   [cm/s]     pre-stimulus    post-stimulus HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46821 fear conditioning test (none) fear training, percent time immobile, day 1   [%]     pre-stimulus    post-stimulus HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46831 fear conditioning test (none) fear training activity burst to footshock (shock reactivity), day 1   [cm/s]  ftr_post_act_burst HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46836 fear conditioning test (none) contextual fear thigmotaxis, percent time spent near chamber walls, day 2   [%]  ctx_thig HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46841 fear conditioning test (none) contextual fear velocity, day 2   [cm/s]  ctx_vel HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46846 fear conditioning test (none) contextual fear percent time immobile, day 2   [%]  ctx_imob HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46851 fear conditioning test (none) cued fear thignotaxis, percent time spent near chamber walls, day 3   [%]     pre-cue    cue HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46861 fear conditioning test (none) cued fear, velocity, day 3   [cm/s]     pre-cue    cue HMDP w/par 94 m 10wks N=7
    HMDPpheno4 46871 fear conditioning test (none) cued fear, percent time immobile, day 3   [%]     pre-cue    cue HMDP w/par 94 m 10wks N=7
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