Graubert1: Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice (2006)

Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res. 2006 May 15;66(10):5029-38.   PubMed 16707424  


       
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Participants Timothy A Graubert       Washington University School of Medicine St. Louis, MO
James W Watters       Washington University School of Medicine St. Louis, MO
Howard L McLeod       University of North Carolina Chapel Hill, NC
With: Fenske TS
ContactTimothy A Graubert     graubert@medicine.wustl.edu     Lab web site
AcknowledgementsFunding provided by NIH GM063340

Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type Phenotype strain survey data set
MPD identifiersGraubert1     MPD:116
Data changelog 2 updates/corrections.       Initial release date: 07/2008.
Formatted citation
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An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined. Animals were evaluated for baseline hematology. Some animals were treated with N-nitroso-N-ethylurea (ENU) and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system. There were two cohorts: 1) controls; 2) treated with 100 mg/kg body weight ENU i.p.

Summary of procedures that were conducted
• complete blood count Hematology.
• histopathology Tumor growth frequency rates. ENU mutagen 100 mg/kg vs. control.
Mice: inbred   20 strains   ♀♂   age 9wks; 12-64wks   2 cohorts