Graubert1: Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice (2006)

Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res. 2006 May 15;66(10):5029-38.   PubMed 16707424  


         
An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined. Animals were evaluated for baseline hematology. Some animals were treated with N-nitroso-N-ethylurea (ENU) and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system. There were two cohorts: 1) controls; 2) treated with 100 mg/kg body weight ENU i.p.

Procedures conducted:
• complete blood count  Hematology.
• histopathology  Tumor growth frequency rates. ENU mutagen 100 mg/kg vs. control.

Graubert1 downloads
• Download Graubert1 project data set     animal data, as uploaded
• Download Graubert1 animal data matrix     with factor-related expansion applied as necessary
• Download Graubert1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Timothy A Graubert       Washington University School of Medicine,  St. Louis, MO
James W Watters       Washington University School of Medicine,  St. Louis, MO
Howard L McLeod       University of North Carolina,  Chapel Hill, NC
Participants Fenske TS
ContactTimothy A Graubert     graubert@medicine.wustl.edu     Lab web site
AcknowledgementsFunding provided by NIH GM063340

Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type Phenotype strain survey data set
MPD identifiersGraubert1     MPD:116
Data changelog 2 updates/corrections.       Initial release date: 07/2008.
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Mice: inbred   20 strains   ♀♂   age 9wks; 12-64wks   2 experimental groups