MPD: Measures involving F1 AD-BXD

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Neuner1:1	Neuner1	body weight	(none)	body weight [g] bw 65901 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo	F1 AD-BXD	55	both	8-65wks	N=2	2019

Neuner1:9	Neuner1	biomarker quantification	(none)	temporal cortex amyloid level (ng/mg total protein) [ng/mg] amyloid 65909 6 mo 14 mo	F1 AD-BXD	23	both	23-57wks	N=2	2019

Neuner1:11	Neuner1	metabolic panel	(none)	blood glucose level [mg/dL] glucose 65911 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:13	Neuner1	Y-maze	(none)	percentage spontaneous alternation in Y-maze [%] Ymaze_spon_alt 65913 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo	F1 AD-BXD	55	both	7-65wks	N=2	2019

Neuner1:21	Neuner1	Y-maze	(none)	age at onset of working memory deficits (age at which spontaneous alternation percentage dropped below 50%, past 6 mo) [n] Ymaze_age_onset 65921	F1 AD-BXD	53	both	23-65wks	N=4	2019

Neuner1:22	Neuner1	Y-maze	(none)	distance traveled in Y-maze [m] Ymaze_dist 65922 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo	F1 AD-BXD	55	both	8-65wks	N=2	2019

Neuner1:30	Neuner1	Y-maze	(none)	number of arm entries in Y-maze [n] Ymaze_ent 65930 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo	F1 AD-BXD	55	both	8-65wks	N=2	2019

Neuner1:38	Neuner1	Y-maze	(none)	percentage of alternating arm returns in Y-maze [%] Ymaze_returns 65938 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo	F1 AD-BXD	55	both	8-65wks	N=2	2019

Neuner1:46	Neuner1	balance beam	(none)	mean time to cross narrow beam, 3 min test, across 3 trials [s] beam_cross 65946 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:48	Neuner1	inclined screen test	(none)	mean time to right body when placed face down on 45 degree inclined screen (negative geotaxis), 3 min test, across 3 trials [s] neg_geotaxis 65948 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:50	Neuner1	grip strength	(none)	mean grip strength across 3 trials [g] grip_strength 65950 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:52	Neuner1	behavior observation	(none)	sensorimotor composite score across narrow beam, inclined screen, grip strength tasks, derived by Z-scores [score] sensorimotor 65952 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:54	Neuner1	elevated plus maze	(none)	distance traveled in elevated plus maze, 6 min test [m] epm_dist 65954 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:56	Neuner1	elevated plus maze	(none)	number of arm entries in elevated plus maze, 6 min test [n] epm_arm_ent 65956 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:58	Neuner1	elevated plus maze	(none)	percentage of entries into open arms in elevated plus maze, 6 min test [%] epm_open_ent 65958 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:60	Neuner1	elevated plus maze	(none)	percentage of time spent in open arms of elevated plus maze, 6 min test [%] epm_open_time 65960 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=6	2019

Neuner1:62	Neuner1	fear conditioning test	(none)	percentage of time spent freezing during 40 s interval post shock at 6 mo of age, day 1 contextual fear conditioning [%] cfc_6mo 65962 baseline 1st shock 2nd shock 3rd shock 4th shock	F1 AD-BXD	50	both	23-25wks	N=3	2019

Neuner1:67	Neuner1	fear conditioning test	(none)	percentage of time spent freezing during 40 s interval post shock at 14 mo of age, day 1 contextual fear conditioning [%] cfc_14mo 65967 baseline 1st shock 2nd shock 3rd shock 4th shock	F1 AD-BXD	51	both	55-57wks	N=4	2019

Neuner1:72	Neuner1	fear conditioning test	(none)	change in percentage of time spent freezing from 1st post-shock to 4th post-shock (slope), day 1 contextual fear acquisition cfa_change 65972 6 mo 14 mo	F1 AD-BXD	55	both	23-57wks	N=3	2019

Neuner1:74	Neuner1	fear conditioning test	(none)	percentage of time spent freezing at 6 mo of age, day 2 contextual fear memory, 10 min test [%] cfm_6mo 65974 1st 2 min 2nd 2 min 3rd 2 min 4th 2 min 5th 2 min total	F1 AD-BXD	50	both	23-25wks	N=3	2019

Neuner1:80	Neuner1	fear conditioning test	(none)	percentage of time spent freezing at 14 mo of age, day 2 contextual fear memory, 10 min test [%] cfm_14mo 65980 1st 2 min 2nd 2 min 3rd 2 min 4th 2 min 5th 2 min total	F1 AD-BXD	51	both	55-57wks	N=4	2019

Neuner1

body weight

(none)

body weight [g] bw 65901 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo

F1 AD-BXD

55

both

8-65wks

N=2

2019

Neuner1

biomarker quantification

(none)

temporal cortex amyloid level (ng/mg total protein) [ng/mg] amyloid 65909 6 mo 14 mo

F1 AD-BXD

23

both

23-57wks

N=2

2019

Neuner1

metabolic panel

(none)

blood glucose level [mg/dL] glucose 65911 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

Y-maze

(none)

percentage spontaneous alternation in Y-maze [%] Ymaze_spon_alt 65913 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo

F1 AD-BXD

55

both

7-65wks

N=2

2019

Neuner1

Y-maze

(none)

age at onset of working memory deficits (age at which spontaneous alternation percentage dropped below 50%, past 6 mo) [n] Ymaze_age_onset 65921

F1 AD-BXD

53

both

23-65wks

N=4

2019

Neuner1

Y-maze

(none)

distance traveled in Y-maze [m] Ymaze_dist 65922 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo

F1 AD-BXD

55

both

8-65wks

N=2

2019

Neuner1

Y-maze

(none)

number of arm entries in Y-maze [n] Ymaze_ent 65930 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo

F1 AD-BXD

55

both

8-65wks

N=2

2019

Neuner1

Y-maze

(none)

percentage of alternating arm returns in Y-maze [%] Ymaze_returns 65938 2 mo 4 mo 6 mo 8 mo 10 mo 12 mo 14 mo 16 mo

F1 AD-BXD

55

both

8-65wks

N=2

2019

Neuner1

balance beam

(none)

mean time to cross narrow beam, 3 min test, across 3 trials [s] beam_cross 65946 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

inclined screen test

(none)

mean time to right body when placed face down on 45 degree inclined screen (negative geotaxis), 3 min test, across 3 trials [s] neg_geotaxis 65948 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

grip strength

(none)

mean grip strength across 3 trials [g] grip_strength 65950 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

behavior observation

(none)

sensorimotor composite score across narrow beam, inclined screen, grip strength tasks, derived by Z-scores [score] sensorimotor 65952 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

elevated plus maze

(none)

distance traveled in elevated plus maze, 6 min test [m] epm_dist 65954 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

elevated plus maze

(none)

number of arm entries in elevated plus maze, 6 min test [n] epm_arm_ent 65956 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

elevated plus maze

(none)

percentage of entries into open arms in elevated plus maze, 6 min test [%] epm_open_ent 65958 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

elevated plus maze

(none)

percentage of time spent in open arms of elevated plus maze, 6 min test [%] epm_open_time 65960 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=6

2019

Neuner1

fear conditioning test

(none)

percentage of time spent freezing during 40 s interval post shock at 6 mo of age, day 1 contextual fear conditioning [%] cfc_6mo 65962 baseline 1st shock 2nd shock 3rd shock 4th shock

F1 AD-BXD

50

both

23-25wks

N=3

2019

Neuner1

fear conditioning test

(none)

percentage of time spent freezing during 40 s interval post shock at 14 mo of age, day 1 contextual fear conditioning [%] cfc_14mo 65967 baseline 1st shock 2nd shock 3rd shock 4th shock

F1 AD-BXD

51

both

55-57wks

N=4

2019

Neuner1

fear conditioning test

(none)

change in percentage of time spent freezing from 1st post-shock to 4th post-shock (slope), day 1 contextual fear acquisition cfa_change 65972 6 mo 14 mo

F1 AD-BXD

55

both

23-57wks

N=3

2019

Neuner1

fear conditioning test

(none)

percentage of time spent freezing at 6 mo of age, day 2 contextual fear memory, 10 min test [%] cfm_6mo 65974 1st 2 min 2nd 2 min 3rd 2 min 4th 2 min 5th 2 min total

F1 AD-BXD

50

both

23-25wks

N=3

2019

Neuner1

fear conditioning test

(none)

percentage of time spent freezing at 14 mo of age, day 2 contextual fear memory, 10 min test [%] cfm_14mo 65980 1st 2 min 2nd 2 min 3rd 2 min 4th 2 min 5th 2 min total

F1 AD-BXD

51

both

55-57wks

N=4

2019

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