Project measures / variables set:   Thomsen2   activ_D2

ID, description, units MPD:40806   activ_D2   total activity, dose response to D2 agonist, 3h test   [n]  
quinelorane study
Measures
• baseline    • dose mg/kg i.p.    • 0.03    • 0.32    • 3.2    • 5.6
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
Comparisonrepeated measures, baseline then treated multiple doses, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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  OVERLAPPING STRAIN CURVES
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Thomsen2 - total activity, dose response to D2 agonist, 3h test


  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   sex 1 17342259.8734 17342259.8734 3.2034 0.0751
between   strain 14 5672026595.4666 405144756.819 74.8363 < 0.0001
between   sex:strain 14 274291697.5423 19592264.1102 3.619 < 0.0001
between   Residuals 189 1023198302.2264 5413747.6308
within   dose 4 140698301.8119 35174575.453 21.1614 < 0.0001
within   dose:sex 4 30177008.6037 7544252.1509 4.5387 0.0013
within   dose:strain 56 3085999294.135 55107130.2524 33.153 < 0.0001
within   dose:sex:strain 56 203238794.6722 3629264.1906 2.1834 < 0.0001
within   Residuals 756 1256626796.7771 1662204.7576

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested		SexAge
Thomsen2 40806 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   baseline  activ_D2_0 inbred 15 both 8-10wks
Thomsen2 40807 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 0.03 mg/kg i.p.  activ_D2_doseA inbred 15 both 8-10wks
Thomsen2 40808 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 0.32 mg/kg i.p.  activ_D2_doseB inbred 15 both 8-10wks
Thomsen2 40809 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 3.2 mg/kg i.p.  activ_D2_doseC inbred 15 both 8-10wks
Thomsen2 40810 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 5.6 mg/kg i.p.  activ_D2_doseD inbred 15 both 8-10wks



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