Phenotype measures set:   Thomsen2   activ_D2

ID, description, units MPD:40806   activ_D2   total activity, dose response to D2 agonist, 3h test   [n]
quinelorane study
Measures • baseline    • dose mg/kg i.p.    • 0.03    • 0.32    • 3.2    • 5.6
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
Comparisonrepeated measures, baseline then treated multiple doses, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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Thomsen2 - total activity, dose response to D2 agonist, 3h test


Female

Male



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Thomsen2 - total activity, dose response to D2 agonist, 3h test





  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   sex 1 17342259.8734 17342259.8734 3.2034 0.0751
between   strain 14 5672026595.4666 405144756.819 74.8363 < 0.0001
between   sex:strain 14 274291697.5423 19592264.1102 3.619 < 0.0001
between   Residuals 189 1023198302.2264 5413747.6308
within   dose 4 140698301.8119 35174575.453 21.1614 < 0.0001
within   dose:sex 4 30177008.6037 7544252.1509 4.5387 0.0013
within   dose:strain 56 3085999294.135 55107130.2524 33.153 < 0.0001
within   dose:sex:strain 56 203238794.6722 3629264.1906 2.1834 < 0.0001
within   Residuals 756 1256626796.7771 1662204.7576

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDDrug or
challenge
Description and varname PanelStrains
tested
SexAge
Thomsen2 40806 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   baseline   activ_D2_0 inbred 15 both 8-10wks
Thomsen2 40807 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 0.03 mg/kg i.p.   activ_D2_doseA inbred 15 both 8-10wks
Thomsen2 40808 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 0.32 mg/kg i.p.   activ_D2_doseB inbred 15 both 8-10wks
Thomsen2 40809 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 3.2 mg/kg i.p.   activ_D2_doseC inbred 15 both 8-10wks
Thomsen2 40810 open field test quinelorane total activity, dose response to D2 agonist, 3h test   [n]   dose 5.6 mg/kg i.p.   activ_D2_doseD inbred 15 both 8-10wks