Project measure / variable:   Thomsen2   activ_D2_doseD

ID, description, units MPD:40810   activ_D2_doseD   total activity, dose response to D2 agonist, 3h test   [n]  dose 5.6 mg/kg i.p.  
quinelorane study
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D2 agonist, 3h test dose 5.6 mg/kg i.p.



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2615   n 3160   n
Median of the strain means1317   n 1059   n
SD of the strain means± 4835 ± 6425
Coefficient of variation (CV)1.85 2.03
Min–max range of strain means143   –   18989   n 125   –   25521   n
Mean sample size per strain7.4   mice 7.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 389921.0666 389921.0666 0.0958 0.7572
strain 14 3543704935.3957 253121781.0997 62.2063 < 0.0001
sex:strain 14 178447192.7254 12746228.0518 3.1325 0.0002
Residuals 189 769053728.8214 4069067.3483


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 341.0 99.9   8 35.3 0.293 234.0, 527.0 -0.47
129S1/SvImJ m 361.0 145.0   7 54.8 0.402 202.0, 644.0 -0.44
129S6/SvEvTac f 255.0 119.0   7 44.9 0.465 47.0, 426.0 -0.49
129S6/SvEvTac m 292.0 121.0   8 42.7 0.414 125.0, 544.0 -0.45
129X1/SvJ f 143.0 107.0   8 37.9 0.749 49.0, 375.0 -0.51
129X1/SvJ m 125.0 39.8   8 14.1 0.319 52.0, 173.0 -0.47
A/J f 229.0 185.0   7 69.8 0.807 20.0, 467.0 -0.49
A/J m 357.0 221.0   7 83.5 0.618 57.0, 629.0 -0.44
BALB/cByJ f 379.0 173.0   7 65.4 0.456 130.0, 672.0 -0.46
BALB/cByJ m 162.0 102.0   8 36.2 0.631 26.0, 274.0 -0.47
BALB/cJ f 2146.0 1404.0   8 496.0 0.654 256.0, 4170.0 -0.1
BALB/cJ m 6437.0 3717.0   8 1314.0 0.577 1419.0, 11001.0 0.51
C3H/HeJ f 2950.0 1962.0   7 741.0 0.665 782.0, 6454.0 0.07
C3H/HeJ m 3054.0 1912.0   8 676.0 0.626 1001.0, 6482.0 -0.02
C57BL/6J f 302.0 124.0   8 43.9 0.411 189.0, 581.0 -0.48
C57BL/6J m 1059.0 501.0   7 189.0 0.473 416.0, 1862.0 -0.33
CAST/EiJ f 18989.0 7472.0   5 3342.0 0.394 9407.0, 25904.0 3.39
CAST/EiJ m 25521.0 3375.0   3 1949.0 0.132 22096.0, 28844.0 3.48
Crl:CD-1(ICR) f 1604.0 3436.0   8 1215.0 2.14 131.0, 10098.0 -0.21
Crl:CD-1(ICR) m 1649.0 3290.0   7 1244.0 2.0 281.0, 9102.0 -0.24
DBA/2J f 179.0 85.6   7 32.3 0.477 49.0, 331.0 -0.5
DBA/2J m 384.0 549.0   8 194.0 1.43 64.0, 1716.0 -0.43
FVB/NJ f 1731.0 860.0   8 304.0 0.497 751.0, 3438.0 -0.18
FVB/NJ m 2266.0 1609.0   8 569.0 0.71 262.0, 5002.0 -0.14
SJL/J f 2020.0 3265.0   8 1154.0 1.62 461.0, 10040.0 -0.12
SJL/J m 861.0 460.0   8 163.0 0.534 353.0, 1820.0 -0.36
SPRET/EiJ f 6637.0 2547.0   5 1139.0 0.384 3667.0, 9922.0 0.83
SPRET/EiJ m 3765.0 2674.0   7 1011.0 0.71 1301.0, 8617.0 0.09
Tac:SW f 1317.0 1675.0   8 592.0 1.27 157.0, 5303.0 -0.27
Tac:SW m 1100.0 1824.0   8 645.0 1.66 144.0, 5570.0 -0.32


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 341.0 713.1854 1747.826 0.0
129S1/SvImJ m 360.7143 762.4273 1864.6746 0.0
129S6/SvEvTac f 255.4286 762.4273 1759.3888 0.0
129S6/SvEvTac m 291.625 713.1854 1698.451 0.0
129X1/SvJ f 143.125 713.1854 1549.951 0.0
129X1/SvJ m 124.875 713.1854 1531.701 0.0
A/J f 229.0 762.4273 1732.9603 0.0
A/J m 357.2857 762.4273 1861.246 0.0
BALB/cByJ f 379.1429 762.4273 1883.1031 0.0
BALB/cByJ m 162.375 713.1854 1569.201 0.0
BALB/cJ f 2146.125 713.1854 3552.951 739.299
BALB/cJ m 6436.875 713.1854 7843.701 5030.049
C3H/HeJ f 2950.2857 762.4273 4454.246 1446.3254
C3H/HeJ m 3053.5 713.1854 4460.326 1646.674
C57BL/6J f 302.25 713.1854 1709.076 0.0
C57BL/6J m 1059.4286 762.4273 2563.3888 0.0
CAST/EiJ f 18988.6 902.1161 20768.1098 17209.0902
CAST/EiJ m 25521.0 1164.6269 27818.3373 23223.6627
Crl:CD-1(ICR) f 1604.375 713.1854 3011.201 197.549
Crl:CD-1(ICR) m 1648.8571 762.4273 3152.8174 144.8969
DBA/2J f 179.4286 762.4273 1683.3888 0.0
DBA/2J m 384.375 713.1854 1791.201 0.0
FVB/NJ f 1730.875 713.1854 3137.701 324.049
FVB/NJ m 2265.5 713.1854 3672.326 858.674
SJL/J f 2020.0 713.1854 3426.826 613.174
SJL/J m 861.0 713.1854 2267.826 0.0
SPRET/EiJ f 6637.2 902.1161 8416.7098 4857.6902
SPRET/EiJ m 3764.7143 762.4273 5268.6746 2260.754
Tac:SW f 1317.125 713.1854 2723.951 0.0
Tac:SW m 1100.0 713.1854 2506.826 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 350.8571 521.9983 1380.5484 0.0
129S6/SvEvTac both 273.5268 521.9983 1303.218 0.0
129X1/SvJ both 134.0 504.2982 1128.7762 0.0
A/J both 293.1429 539.1175 1356.6034 0.0
BALB/cByJ both 270.7589 521.9983 1300.4501 0.0
BALB/cJ both 4291.5 504.2982 5286.2762 3296.7238
C3H/HeJ both 3001.8929 521.9983 4031.5841 1972.2016
C57BL/6J both 680.8393 521.9983 1710.5305 0.0
CAST/EiJ both 22254.8 736.5747 23707.7637 20801.8363
Crl:CD-1(ICR) both 1626.6161 521.9983 2656.3073 596.9249
DBA/2J both 281.9018 521.9983 1311.593 0.0
FVB/NJ both 1998.1875 504.2982 2992.9637 1003.4113
SJL/J both 1440.5 504.2982 2435.2762 445.7238
SPRET/EiJ both 5200.9571 590.5736 6365.9198 4035.9945
Tac:SW both 1208.5625 504.2982 2203.3387 213.7863




  GWAS USING LINEAR MIXED MODELS