Project measure / variable:   Thomsen2   activ_D2_0

ID, description, units MPD:40806   activ_D2_0   total activity, dose response to D2 agonist, 3h test   [n]  baseline  
quinelorane study
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D2 agonist, 3h test baseline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2510   n 1879   n
Median of the strain means2237   n 1343   n
SD of the strain means± 2255 ± 1668
Coefficient of variation (CV)0.899 0.887
Min–max range of strain means218   –   8070   n 197   –   5606   n
Mean sample size per strain7.7   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 29452240.7846 29452240.7846 15.5649 0.0001
strain 14 725694849.2165 51835346.3726 27.394 < 0.0001
sex:strain 14 113384621.2623 8098901.5187 4.2801 < 0.0001
Residuals 197 372766786.1464 1892217.1886


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 426.0 141.0   8 49.7 0.33 215.0, 658.0 -0.92
129S1/SvImJ m 562.0 231.0   8 81.7 0.411 271.0, 969.0 -0.79
129S6/SvEvTac f 475.0 213.0   8 75.3 0.448 131.0, 674.0 -0.9
129S6/SvEvTac m 490.0 178.0   8 62.9 0.363 216.0, 697.0 -0.83
129X1/SvJ f 218.0 106.0   8 37.3 0.484 122.0, 444.0 -1.02
129X1/SvJ m 197.0 67.2   8 23.8 0.341 116.0, 293.0 -1.01
A/J f 2237.0 1218.0   8 431.0 0.545 670.0, 4478.0 -0.12
A/J m 1343.0 1099.0   8 389.0 0.818 574.0, 3760.0 -0.32
BALB/cByJ f 5636.0 1389.0   7 525.0 0.247 3051.0, 7576.0 1.39
BALB/cByJ m 2078.0 1644.0   8 581.0 0.791 482.0, 5124.0 0.12
BALB/cJ f 5006.0 1699.0   8 601.0 0.339 1388.0, 6886.0 1.11
BALB/cJ m 5606.0 694.0   8 245.0 0.124 4654.0, 6371.0 2.23
C3H/HeJ f 743.0 423.0   8 149.0 0.569 392.0, 1583.0 -0.78
C3H/HeJ m 1860.0 894.0   8 316.0 0.481 409.0, 3271.0 -0.01
C57BL/6J f 2528.0 734.0   8 260.0 0.29 1784.0, 3870.0 0.01
C57BL/6J m 2045.0 588.0   7 222.0 0.288 1316.0, 3140.0 0.1
CAST/EiJ f 2786.0 2531.0   6 1033.0 0.908 116.0, 6906.0 0.12
CAST/EiJ m 4103.0 2433.0   4 1216.0 0.593 1845.0, 6358.0 1.33
Crl:CD-1(ICR) f 2342.0 2676.0   8 946.0 1.14 241.0, 7028.0 -0.07
Crl:CD-1(ICR) m 2097.0 2566.0   8 907.0 1.22 389.0, 6757.0 0.13
DBA/2J f 1426.0 1072.0   7 405.0 0.752 74.0, 2947.0 -0.48
DBA/2J m 839.0 158.0   8 56.0 0.189 622.0, 1041.0 -0.62
FVB/NJ f 8070.0 951.0   8 336.0 0.118 6362.0, 9513.0 2.47
FVB/NJ m 4734.0 2446.0   8 865.0 0.517 1861.0, 8808.0 1.71
SJL/J f 1204.0 1148.0   8 406.0 0.954 352.0, 3076.0 -0.58
SJL/J m 718.0 403.0   8 143.0 0.561 327.0, 1590.0 -0.7
SPRET/EiJ f 817.0 598.0   5 268.0 0.733 244.0, 1586.0 -0.75
SPRET/EiJ m 531.0 263.0   7 99.4 0.495 219.0, 1025.0 -0.81
Tac:SW f 3734.0 2994.0   8 1058.0 0.802 557.0, 7827.0 0.54
Tac:SW m 984.0 1181.0   8 417.0 1.2 214.0, 3789.0 -0.54


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 426.125 486.3406 1385.227 0.0
129S1/SvImJ m 562.0 486.3406 1521.102 0.0
129S6/SvEvTac f 475.125 486.3406 1434.227 0.0
129S6/SvEvTac m 490.125 486.3406 1449.227 0.0
129X1/SvJ f 218.25 486.3406 1177.352 0.0
129X1/SvJ m 197.25 486.3406 1156.352 0.0
A/J f 2237.375 486.3406 3196.477 1278.273
A/J m 1343.375 486.3406 2302.477 384.273
BALB/cByJ f 5636.0 519.9199 6661.3232 4610.6768
BALB/cByJ m 2077.875 486.3406 3036.977 1118.773
BALB/cJ f 5006.125 486.3406 5965.227 4047.023
BALB/cJ m 5605.625 486.3406 6564.727 4646.523
C3H/HeJ f 742.625 486.3406 1701.727 0.0
C3H/HeJ m 1859.75 486.3406 2818.852 900.648
C57BL/6J f 2528.5 486.3406 3487.602 1569.398
C57BL/6J m 2045.0 519.9199 3070.3232 1019.6768
CAST/EiJ f 2786.0 561.5777 3893.4756 1678.5244
CAST/EiJ m 4103.25 687.7894 5459.6251 2746.8749
Crl:CD-1(ICR) f 2341.625 486.3406 3300.727 1382.523
Crl:CD-1(ICR) m 2096.75 486.3406 3055.852 1137.648
DBA/2J f 1426.4286 519.9199 2451.7518 401.1054
DBA/2J m 839.125 486.3406 1798.227 0.0
FVB/NJ f 8069.875 486.3406 9028.977 7110.773
FVB/NJ m 4733.625 486.3406 5692.727 3774.523
SJL/J f 1203.625 486.3406 2162.727 244.523
SJL/J m 718.25 486.3406 1677.352 0.0
SPRET/EiJ f 816.6 615.1776 2029.7788 0.0
SPRET/EiJ m 531.1429 519.9199 1556.4661 0.0
Tac:SW f 3734.0 486.3406 4693.102 2774.898
Tac:SW m 983.875 486.3406 1942.977 24.773


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 494.0625 343.8947 1172.2501 0.0
129S6/SvEvTac both 482.625 343.8947 1160.8126 0.0
129X1/SvJ both 207.75 343.8947 885.9376 0.0
A/J both 1790.375 343.8947 2468.5626 1112.1874
BALB/cByJ both 3856.9375 355.9648 4558.9283 3154.9467
BALB/cJ both 5305.875 343.8947 5984.0626 4627.6874
C3H/HeJ both 1301.1875 343.8947 1979.3751 622.9999
C57BL/6J both 2286.75 355.9648 2988.7408 1584.7592
CAST/EiJ both 3444.625 443.9662 4320.1614 2569.0886
Crl:CD-1(ICR) both 2219.1875 343.8947 2897.3751 1540.9999
DBA/2J both 1132.7768 355.9648 1834.7676 430.786
FVB/NJ both 6401.75 343.8947 7079.9376 5723.5624
SJL/J both 960.9375 343.8947 1639.1251 282.7499
SPRET/EiJ both 673.8714 402.7283 1468.0834 0.0
Tac:SW both 2358.9375 343.8947 3037.1251 1680.7499




  GWAS USING LINEAR MIXED MODELS