Phenotype measure:   Thomsen2   activ_D2_doseA


  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D2 agonist, 3h test dose 0.03 mg/kg i.p.



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means1776   n 1470   n
Median of the strain means1356   n 884   n
SD of the strain means± 1582 ± 1451
Coefficient of variation (CV)0.890 0.987
Min–max range of strain means135   –   5217   n 158   –   4593   n
Mean sample size per strain7.7   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7279622.6593 7279622.6593 5.2701 0.0228
strain 14 408679473.6501 29191390.975 21.1333 < 0.0001
sex:strain 14 49339871.9263 3524276.5662 2.5514 0.0022
Residuals 196 270734930.5298 1381300.666


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 260.0 150.0   8 53.1 0.578 64.0, 467.0 -0.96
129S1/SvImJ m 414.0 180.0   8 63.7 0.435 215.0, 718.0 -0.73
129S6/SvEvTac f 288.0 197.0   8 69.5 0.682 88.0, 661.0 -0.94
129S6/SvEvTac m 280.0 122.0   8 43.1 0.435 120.0, 524.0 -0.82
129X1/SvJ f 135.0 65.0   8 23.0 0.483 43.0, 236.0 -1.04
129X1/SvJ m 158.0 69.2   8 24.5 0.438 84.0, 269.0 -0.9
A/J f 819.0 415.0   8 147.0 0.506 390.0, 1726.0 -0.61
A/J m 553.0 355.0   7 134.0 0.642 331.0, 1348.0 -0.63
BALB/cByJ f 3354.0 2479.0   7 937.0 0.739 1226.0, 7204.0 1.0
BALB/cByJ m 760.0 462.0   8 163.0 0.608 190.0, 1342.0 -0.49
BALB/cJ f 3204.0 1062.0   8 375.0 0.331 814.0, 4200.0 0.9
BALB/cJ m 4246.0 1462.0   8 517.0 0.344 1953.0, 6648.0 1.91
C3H/HeJ f 717.0 408.0   8 144.0 0.569 207.0, 1441.0 -0.67
C3H/HeJ m 1524.0 579.0   8 205.0 0.38 800.0, 2543.0 0.04
C57BL/6J f 1740.0 462.0   8 163.0 0.266 1265.0, 2414.0 -0.02
C57BL/6J m 1573.0 601.0   7 227.0 0.382 928.0, 2787.0 0.07
CAST/EiJ f 4335.0 2976.0   6 1215.0 0.687 508.0, 7114.0 1.62
CAST/EiJ m 4593.0 976.0   4 488.0 0.212 3536.0, 5759.0 2.15
Crl:CD-1(ICR) f 1356.0 966.0   8 342.0 0.712 332.0, 2817.0 -0.27
Crl:CD-1(ICR) m 1670.0 1966.0   8 695.0 1.18 305.0, 5544.0 0.14
DBA/2J f 745.0 897.0   7 339.0 1.2 222.0, 2713.0 -0.65
DBA/2J m 376.0 122.0   8 43.2 0.325 212.0, 543.0 -0.75
FVB/NJ f 5217.0 1512.0   8 535.0 0.29 3243.0, 7331.0 2.18
FVB/NJ m 3373.0 2914.0   8 1030.0 0.864 780.0, 9434.0 1.31
SJL/J f 574.0 413.0   8 146.0 0.719 158.0, 1328.0 -0.76
SJL/J m 389.0 277.0   8 98.1 0.713 116.0, 976.0 -0.75
SPRET/EiJ f 1714.0 761.0   5 340.0 0.444 914.0, 2849.0 -0.04
SPRET/EiJ m 1262.0 876.0   7 331.0 0.694 338.0, 2677.0 -0.14
Tac:SW f 2186.0 1866.0   8 660.0 0.853 488.0, 5557.0 0.26
Tac:SW m 884.0 881.0   8 311.0 0.997 175.0, 2347.0 -0.4


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 260.0 415.5269 1079.4777 0.0
129S1/SvImJ m 413.875 415.5269 1233.3527 0.0
129S6/SvEvTac f 288.25 415.5269 1107.7277 0.0
129S6/SvEvTac m 279.875 415.5269 1099.3527 0.0
129X1/SvJ f 134.75 415.5269 954.2277 0.0
129X1/SvJ m 157.875 415.5269 977.3527 0.0
A/J f 819.0 415.5269 1638.4777 0.0
A/J m 552.8571 444.2169 1428.9156 0.0
BALB/cByJ f 3354.4286 444.2169 4230.4871 2478.3701
BALB/cByJ m 760.25 415.5269 1579.7277 0.0
BALB/cJ f 3203.875 415.5269 4023.3527 2384.3973
BALB/cJ m 4245.75 415.5269 5065.2277 3426.2723
C3H/HeJ f 717.125 415.5269 1536.6027 0.0
C3H/HeJ m 1523.625 415.5269 2343.1027 704.1473
C57BL/6J f 1739.5 415.5269 2558.9777 920.0223
C57BL/6J m 1573.4286 444.2169 2449.4871 697.3701
CAST/EiJ f 4334.8333 479.8091 5281.0846 3388.582
CAST/EiJ m 4593.0 587.6437 5751.9164 3434.0836
Crl:CD-1(ICR) f 1356.5 415.5269 2175.9777 537.0223
Crl:CD-1(ICR) m 1670.5 415.5269 2489.9777 851.0223
DBA/2J f 744.7143 444.2169 1620.7728 0.0
DBA/2J m 376.0 415.5269 1195.4777 0.0
FVB/NJ f 5216.75 415.5269 6036.2277 4397.2723
FVB/NJ m 3373.25 415.5269 4192.7277 2553.7723
SJL/J f 574.25 415.5269 1393.7277 0.0
SJL/J m 389.0 415.5269 1208.4777 0.0
SPRET/EiJ f 1714.0 525.6045 2750.5664 677.4336
SPRET/EiJ m 1262.1429 444.2169 2138.2013 386.0844
Tac:SW f 2186.25 415.5269 3005.7277 1366.7723
Tac:SW m 883.875 415.5269 1703.3527 64.3973


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 336.9375 293.8219 916.3957 0.0
129S6/SvEvTac both 284.0625 293.8219 863.5207 0.0
129X1/SvJ both 146.3125 293.8219 725.7707 0.0
A/J both 685.9286 304.1345 1285.7248 86.1323
BALB/cByJ both 2057.3393 304.1345 2657.1355 1457.543
BALB/cJ both 3724.8125 293.8219 4304.2707 3145.3543
C3H/HeJ both 1120.375 293.8219 1699.8332 540.9168
C57BL/6J both 1656.4643 304.1345 2256.2605 1056.668
CAST/EiJ both 4463.9167 379.3224 5211.994 3715.8393
Crl:CD-1(ICR) both 1513.5 293.8219 2092.9582 934.0418
DBA/2J both 560.3571 304.1345 1160.1534 0.0
FVB/NJ both 4295.0 293.8219 4874.4582 3715.5418
SJL/J both 481.625 293.8219 1061.0832 0.0
SPRET/EiJ both 1488.0714 344.0889 2166.6634 809.4794
Tac:SW both 1535.0625 293.8219 2114.5207 955.6043




  GWAS USING LINEAR MIXED MODELS