Project measure / variable:   Rusyn2   TCA_8_tce

ID, description, units MPD:36176   TCA_8_tce   trichloroacetic acid (serum TCA)   [nmol/mL]  8h after treatment  
trichloroethylene study
Data set, strains Rusyn2   inbred   15 strains     sex: m     age: 7wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Rusyn2 - trichloroacetic acid (serum TCA) 8h after treatment



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means732   nmol/mL
Median of the strain means591   nmol/mL
SD of the strain means± 381
Coefficient of variation (CV)0.521
Min–max range of strain means388   –   1763   nmol/mL
Mean sample size per strain2.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 13 6068178.9492 466782.9961 6.4228 < 0.0001
Residuals 25 1816901.3067 72676.0523


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 504.0 138.0   3 79.8 0.274 346.0, 603.0 -0.6
A/J m 405.0 191.0   3 110.0 0.47 190.0, 553.0 -0.86
B6C3F1/J m 388.0 19.6   3 11.3 0.0504 368.0, 407.0 -0.9
BALB/cByJ m 585.0 228.0   3 132.0 0.39 373.0, 826.0 -0.39
BTBR T+ Itpr3tf/J m 417.0 21.9   3 12.7 0.0527 404.0, 442.0 -0.83
C3H/HeJ m 465.0 455.0   3 263.0 0.979 92.1, 972.0 -0.7
C57BL/6J m 539.0 169.0   3 97.6 0.314 406.0, 729.0 -0.51
CAST/EiJ m 672.0 38.9   2   27.5 0.0578 645.0, 700.0 -0.16
DBA/2J m 1061.0 134.0   3 77.4 0.126 924.0, 1192.0 0.86
FVB/NJ m 1158.0 393.0   3 227.0 0.34 717.0, 1472.0 1.12
KK/HlJ m 1108.0 526.0   3 304.0 0.475 501.0, 1412.0 0.99
MOLF/EiJ m 591.0 0.0   2   0.0 0.0 591.0, 591.0 -0.37
NOD/ShiLtJ m 704.0 0.0   1   0.0 0.0 704.0, 704.0 -0.07
NZW/LacJ m 1763.0 53.1   3 30.7 0.0301 1732.0, 1824.0 2.7
PWD/PhJ m 623.0 472.0   2   334.0 0.758 289.0, 957.0 -0.29


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 504.0 155.645 824.5568 183.4432
A/J m 405.0 155.645 725.5568 84.4432
B6C3F1/J m 388.3333 155.645 708.8901 67.7766
BALB/cByJ m 585.0 155.645 905.5568 264.4432
BTBR T+ Itpr3tf/J m 416.6667 155.645 737.2234 96.1099
C3H/HeJ m 464.7 155.645 785.2568 144.1432
C57BL/6J m 538.6667 155.645 859.2234 218.1099
CAST/EiJ m 672.5 190.6254 1065.1003 279.8997
DBA/2J m 1060.6667 155.645 1381.2234 740.1099
FVB/NJ m 1158.3333 155.645 1478.8901 837.7766
KK/HlJ m 1108.3333 155.645 1428.8901 787.7766
MOLF/EiJ m 591.0 190.6254 983.6003 198.3997
NZW/LacJ m 1762.6667 155.645 2083.2234 1442.1099
PWD/PhJ m 623.0 190.6254 1015.6003 230.3997




  GWAS USING LINEAR MIXED MODELS