Project measure / variable:   Rusyn2   DCA_24_tce

ID, description, units MPD:36169   DCA_24_tce   dichloroacetic acid (serum DCA x 10-3)   [nmol/mL]  24h after treatment  
trichloroethylene study
Data set, strains Rusyn2   inbred   15 strains     sex: m     age: 7wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Rusyn2 - dichloroacetic acid (serum DCA x 10-3) 24h after treatment



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means50.6   nmol/mL
Median of the strain means30.0   nmol/mL
SD of the strain means± 59.6
Coefficient of variation (CV)1.18
Min–max range of strain means0   –   180   nmol/mL
Mean sample size per strain2.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 12 73988.8889 6165.7407 11.8177 < 0.0001
Residuals 23 12000.0 521.7391


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 170.0 0.0   2   0.0 0.0 170.0, 170.0 2.0
A/J m 70.0 0.0   2   0.0 0.0 70.0, 70.0 0.33
B6C3F1/J m 40.0 36.1   3 20.8 0.901 -0.18
BALB/cByJ m 30.0 0.0   3 0.0 0.0 30.0, 30.0 -0.35
BTBR T+ Itpr3tf/J m 10.0 0.0   1   0.0 0.0 10.0, 10.0 -0.68
C3H/HeJ m 13.3 23.1   3 13.3 1.73 -0.63
C57BL/6J m 180.0 0.0   1   0.0 0.0 180.0, 180.0 2.17
CAST/EiJ m 113.0 63.5   3 36.7 0.56 40.0, 150.0 1.05
DBA/2J m 10.0 0.0   2   0.0 0.0 10.0, 10.0 -0.68
FVB/NJ m 60.0 10.0   3 5.77 0.167 50.0, 70.0 0.16
KK/HlJ m 13.3 5.77   3 3.33 0.433 10.0, 20.0 -0.63
MOLF/EiJ m 0.0 0.0   3 0.0 0.0 -0.85
NOD/ShiLtJ m 0.0 0.0   3 0.0 0.0 -0.85
NZW/LacJ m 50.0 0.0   3 0.0 0.0 50.0, 50.0 -0.01
PWD/PhJ m 0.0 0.0   3 0.0 0.0 -0.85


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 170.0 16.1515 203.4118 136.5882
A/J m 70.0 16.1515 103.4118 36.5882
B6C3F1/J m 40.0 13.1876 67.2806 12.7194
BALB/cByJ m 30.0 13.1876 57.2806 2.7194
C3H/HeJ m 13.3333 13.1876 40.614 -13.9473
CAST/EiJ m 113.3333 13.1876 140.614 86.0527
DBA/2J m 10.0 16.1515 43.4118 -23.4118
FVB/NJ m 60.0 13.1876 87.2806 32.7194
KK/HlJ m 13.3333 13.1876 40.614 -13.9473
MOLF/EiJ m 0.0 13.1876 27.2806 -27.2806
NOD/ShiLtJ m 0.0 13.1876 27.2806 -27.2806
NZW/LacJ m 50.0 13.1876 77.2806 22.7194
PWD/PhJ m 0.0 13.1876 27.2806 -27.2806




  GWAS USING LINEAR MIXED MODELS