Project measure / variable:   Rusyn2   DCA_2_tce

ID, description, units MPD:36167   DCA_2_tce   dichloroacetic acid (serum DCA x 10-3)   [nmol/mL]  2h after treatment  
trichloroethylene study
Data set, strains Rusyn2   inbred   15 strains     sex: m     age: 7wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Rusyn2 - dichloroacetic acid (serum DCA x 10-3) 2h after treatment



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means52.8   nmol/mL
Median of the strain means40.0   nmol/mL
SD of the strain means± 34.6
Coefficient of variation (CV)0.656
Min–max range of strain means0   –   120   nmol/mL
Mean sample size per strain2.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 13 46483.3333 3575.641 0.8977 0.5666
Residuals 25 99583.3333 3983.3333


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 30.0 28.3   2   20.0 0.943 10.0, 50.0 -0.66
A/J m 40.0 0.0   1   0.0 0.0 40.0, 40.0 -0.37
B6C3F1/J m 66.7 15.3   3 8.82 0.229 50.0, 80.0 0.4
BALB/cByJ m 46.7 56.9   3 32.8 1.22 -0.18
BTBR T+ Itpr3tf/J m 26.7 20.8   3 12.0 0.781 10.0, 50.0 -0.75
C3H/HeJ m 53.3 5.77   3 3.33 0.108 50.0, 60.0 0.02
C57BL/6J m 26.7 5.77   3 3.33 0.217 20.0, 30.0 -0.75
CAST/EiJ m 76.7 11.5   3 6.67 0.151 70.0, 90.0 0.69
DBA/2J m 0.0 0.0   3 0.0 0.0 -1.52
FVB/NJ m 26.7 15.3   3 8.82 0.573 10.0, 40.0 -0.75
KK/HlJ m 120.0 191.0   3 110.0 1.59 1.94
MOLF/EiJ m 40.0 0.0   2   0.0 0.0 40.0, 40.0 -0.37
NOD/ShiLtJ m 30.0 34.6   3 20.0 1.15 10.0, 70.0 -0.66
NZW/LacJ m 103.0 85.0   3 49.1 0.823 40.0, 200.0 1.45
PWD/PhJ m 105.0 21.2   2   15.0 0.202 90.0, 120.0 1.51


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 30.0 44.6281 121.9133 -61.9133
B6C3F1/J m 66.6667 36.4387 141.7135 -8.3802
BALB/cByJ m 46.6667 36.4387 121.7135 -28.3802
BTBR T+ Itpr3tf/J m 26.6667 36.4387 101.7135 -48.3802
C3H/HeJ m 53.3333 36.4387 128.3802 -21.7135
C57BL/6J m 26.6667 36.4387 101.7135 -48.3802
CAST/EiJ m 76.6667 36.4387 151.7135 1.6198
DBA/2J m 0.0 36.4387 75.0469 -75.0469
FVB/NJ m 26.6667 36.4387 101.7135 -48.3802
KK/HlJ m 120.0 36.4387 195.0469 44.9531
MOLF/EiJ m 40.0 44.6281 131.9133 -51.9133
NOD/ShiLtJ m 30.0 36.4387 105.0469 -45.0469
NZW/LacJ m 103.3333 36.4387 178.3802 28.2865
PWD/PhJ m 105.0 44.6281 196.9133 13.0867




  GWAS USING LINEAR MIXED MODELS