Project measure / variable:   Rusyn2   DCA_8_tce

ID, description, units MPD:36168   DCA_8_tce   dichloroacetic acid (serum DCA x 10-3)   [nmol/mL]  8h after treatment  
trichloroethylene study
Data set, strains Rusyn2   inbred   15 strains     sex: m     age: 7wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Rusyn2 - dichloroacetic acid (serum DCA x 10-3) 8h after treatment



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means324   nmol/mL
Median of the strain means120   nmol/mL
SD of the strain means± 596
Coefficient of variation (CV)1.84
Min–max range of strain means13.3   –   2410   nmol/mL
Mean sample size per strain2.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 13 14770410.2564 1136185.4043 3.2174 0.0059
Residuals 25 8828466.6667 353138.6667


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 13.3 23.1   3 13.3 1.73 -0.52
A/J m 73.3 77.7   3 44.8 1.06 10.0, 160.0 -0.42
B6C3F1/J m 60.0 26.5   3 15.3 0.441 40.0, 90.0 -0.44
BALB/cByJ m 50.0 55.7   3 32.1 1.11 -0.46
BTBR T+ Itpr3tf/J m 2410.0 1905.0   3 1100.0 0.791 1310.0, 4610.0 3.5
C3H/HeJ m 480.0 806.0   3 465.0 1.68 0.26
C57BL/6J m 120.0 166.0   3 96.1 1.39 -0.34
CAST/EiJ m 380.0 410.0   2   290.0 1.08 90.0, 670.0 0.09
DBA/2J m 60.0 0.0   3 0.0 0.0 60.0, 60.0 -0.44
FVB/NJ m 86.7 65.1   3 37.6 0.751 20.0, 150.0 -0.4
KK/HlJ m 213.0 63.5   3 36.7 0.298 140.0, 250.0 -0.19
MOLF/EiJ m 50.0 0.0   2   0.0 0.0 50.0, 50.0 -0.46
NOD/ShiLtJ m 230.0 0.0   1   0.0 0.0 230.0, 230.0 -0.16
NZW/LacJ m 410.0 69.3   3 40.0 0.169 330.0, 450.0 0.14
PWD/PhJ m 220.0 14.1   2   10.0 0.0643 210.0, 230.0 -0.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 13.3333 343.0931 719.9468 0.0
A/J m 73.3333 343.0931 779.9468 0.0
B6C3F1/J m 60.0 343.0931 766.6135 0.0
BALB/cByJ m 50.0 343.0931 756.6135 0.0
BTBR T+ Itpr3tf/J m 2410.0 343.0931 3116.6135 1703.3865
C3H/HeJ m 480.0 343.0931 1186.6135 0.0
C57BL/6J m 120.0 343.0931 826.6135 0.0
CAST/EiJ m 380.0 420.2015 1245.4213 0.0
DBA/2J m 60.0 343.0931 766.6135 0.0
FVB/NJ m 86.6667 343.0931 793.2802 0.0
KK/HlJ m 213.3333 343.0931 919.9468 0.0
MOLF/EiJ m 50.0 420.2015 915.4213 0.0
NZW/LacJ m 410.0 343.0931 1116.6135 0.0
PWD/PhJ m 220.0 420.2015 1085.4213 0.0




  GWAS USING LINEAR MIXED MODELS